Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jonathan W, Dickerson"'
Autor:
Lisa Barbaro, Alice L. Rodriguez, Ashlyn N. Blevins, Jonathan W. Dickerson, Natasha Billard, Olivier Boutaud, Jerri L. Rook, Colleen M. Niswender, P.Jeffrey Conn, Darren W. Engers, Craig W. Lindsley
Publikováno v:
ACS Bio & Med Chem Au, Vol 1, Iss 1, Pp 21-30 (2021)
Externí odkaz:
https://doaj.org/article/a1962d9086d84ecabe40eff8d58cb02f
Autor:
Sichen Chang, Jonathan W. Dickerson, Baker Logan A, Thomas M. Bridges, Craig W. Lindsley, Darren W. Engers, Aidong Qi, Jerri M. Rook, Aaron M. Bender, P. Jeffrey Conn, Katrina A. Bollinger, Colleen M. Niswender, Changho Han, Alice L. Rodriguez, Trever R Carter, Li Peng, Julie L. Engers, Jordan C. O’Neill, Matthew Spock, Katherine J. Watson
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein, we report the SAR leading to the discovery of VU6028418, a potent M(4) mAChR antagonist with high subtype-selectivity and attractive DMPK properties in vitro and in vivo across multiple species. VU6028418 was subsequently ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388290e5061b99e6a85f95357b9a3b32
https://doi.org/10.1021/acsmedchemlett.1c00363
https://doi.org/10.1021/acsmedchemlett.1c00363
Autor:
Jerri M. Rook, Aaron M. Bender, Colleen M. Niswender, Yuping Donsante, P. Jeffrey Conn, Hyekyung P. Cho, Li Peng, Julie L. Engers, Jonathan W. Dickerson, Thomas M. Bridges, Craig W. Lindsley, Ellen J. Hess, Sichen Chang, Aidong Qi, Weimin Peng, Mark S. Moehle, Jordan C. O’Neill, Daniel J. Foster, Alice L. Rodriguez, Zoey Bryant, Katherine J. Watson, Kaylee J. Stillwell
Publikováno v:
ACS Pharmacology & Translational Science. 4:1306-1321
Nonselective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson's disease and dystonia. Despite their efficacy in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5425dfe0a6fb74da410878130ec6660
https://doi.org/10.1021/acsptsci.0c00162
https://doi.org/10.1021/acsptsci.0c00162
Autor:
Darren W. Engers, Natasha Billard, Colleen M. Niswender, Ashlyn N. Blevins, Olivier Boutaud, Jonathan W. Dickerson, P. Jeffrey Conn, Jerri L. Rook, Craig W. Lindsley, Alice L. Rodriguez, Lisa Barbaro
Publikováno v:
ACS Bio & Med Chem Au, Vol 1, Iss 1, Pp 21-30 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6207100701021f062c871e381bbd20f
https://doaj.org/article/a1962d9086d84ecabe40eff8d58cb02f
https://doaj.org/article/a1962d9086d84ecabe40eff8d58cb02f
Autor:
Aaron M, Bender, Trever R, Carter, Matthew, Spock, Alice L, Rodriguez, Jonathan W, Dickerson, Jerri M, Rook, Sichen, Chang, Aidong, Qi, Christopher C, Presley, Darren W, Engers, Joel M, Harp, Thomas M, Bridges, Colleen M, Niswender, P Jeffrey, Conn, Craig W, Lindsley
Publikováno v:
Bioorganicmedicinal chemistry letters. 56
In this manuscript, we report a series of chiral 6-azaspiro[2.5]octanes and related spirocycles as highly potent and selective antagonists of the muscarinic acetylcholine receptor subtype 4 (mAChR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15d71c45fc9259c6cf1b62b08759c9b1
https://pubmed.ncbi.nlm.nih.gov/34838649
https://pubmed.ncbi.nlm.nih.gov/34838649
Autor:
Caitlin N, Kent, Mark G, Fulton, Kaylee J, Stillwell, Jonathan W, Dickerson, Matthew T, Loch, Alice L, Rodriguez, Anna L, Blobaum, Olivier, Boutaud, Jerri L, Rook, Colleen M, Niswender, P Jeffrey, Conn, Craig W, Lindsley
Publikováno v:
Bioorganicmedicinal chemistry letters. 37
A high throughput screen (HTS) identified a novel, but weak (EC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa0e4acb766ebacc10e8996ddcf9fb14
https://pubmed.ncbi.nlm.nih.gov/33556572
https://pubmed.ncbi.nlm.nih.gov/33556572
Autor:
Sichen Chang, Ellen J. Hess, Jerri M. Rook, Jonathan W. Dickerson, Colleen M. Niswender, Yuping Donsante, Weimin Peng, Craig W. Lindsley, Li Peng, Julie L. Engers, Thomas M. Bridges, Mark S. Moehle, Daniel J. Foster, P. Jeffrey Conn, Aaron M. Bender, Alice L. Rodriguez, Zoey Bryant, Katherine J. Watson, Jordan C. O’Neill
Non-selective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson disease and dystonia. Despite their efficacy in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2f6ae5b896aa0960348eb4cabab3c6e
https://doi.org/10.1101/2020.10.12.324152
https://doi.org/10.1101/2020.10.12.324152
Autor:
Mark S, Moehle, Aaron M, Bender, Jonathan W, Dickerson, Daniel J, Foster, Aidong, Qi, Hyekyung P, Cho, Yuping, Donsante, Weimin, Peng, Zoey, Bryant, Kaylee J, Stillwell, Thomas M, Bridges, Sichen, Chang, Katherine J, Watson, Jordan C, O'Neill, Julie L, Engers, Li, Peng, Alice L, Rodriguez, Colleen M, Niswender, Craig W, Lindsley, Ellen J, Hess, P Jeffrey, Conn, Jerri M, Rook
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Nonselective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson’s disease and dystonia. Despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::201a9605778eafcb97e04614395cae35
https://pubmed.ncbi.nlm.nih.gov/34423268
https://pubmed.ncbi.nlm.nih.gov/34423268
Autor:
Jerri M. Rook, P. Jeffrey Conn, Aidong Qi, Aaron M. Bender, Matthew Spock, Colleen M. Niswender, Thomas M. Bridges, Sichen Chang, Trever R Carter, Craig W. Lindsley, Joel M. Harp, Christopher C Presley, Alice L. Rodriguez, Darren W. Engers, Jonathan W. Dickerson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 56:128479
In this manuscript, we report a series of chiral 6-azaspiro[2.5]octanes and related spirocycles as highly potent and selective antagonists of the muscarinic acetylcholine receptor subtype 4 (mAChR4). Chiral separation and subsequent X-ray crystallogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e9bcf50b4cdb04cbbd84852b4ecd42f
https://doi.org/10.1016/j.bmcl.2021.128479
https://doi.org/10.1016/j.bmcl.2021.128479
Autor:
Anna L. Blobaum, Jerri M. Rook, Jonathan W. Dickerson, Colleen M. Niswender, Julie L. Engers, Hekyung P Cho, Elizabeth S. Childress, Darren W. Engers, Rory A. Capstick, P. Jeffrey Conn, Craig W. Lindsley, Vincent B. Luscombe, Madeline F. Long
Publikováno v:
ACS Medicinal Chemistry Letters. 9:917-922
[Image: see text] Herein, we report the chemical optimization of a new series of M(1) positive allosteric modulators (PAMs) based on a novel pyrrolo[2,3-b]pyridine core, developed via scaffold hopping and iterative parallel synthesis. The vast majori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7814bce28c4b007cc453c0d3f611c1b2
https://doi.org/10.1021/acsmedchemlett.8b00261
https://doi.org/10.1021/acsmedchemlett.8b00261