Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jonathan Vesin"'
Autor:
Sevan Habeshian, Manuel Leonardo Merz, Gontran Sangouard, Ganesh Kumar Mothukuri, Mischa Schüttel, Zsolt Bognár, Cristina Díaz-Perlas, Jonathan Vesin, Julien Bortoli Chapalay, Gerardo Turcatti, Laura Cendron, Alessandro Angelini, Christian Heinis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Macrocycles have potential as therapeutics, but their libraries are currently not large enough for high-throughput screening. Here, the authors show a combinatorial approach to generate a library of almost 20’000 macrocycles by conjugating carboxyl
Externí odkaz:
https://doaj.org/article/210437f443a543c6824039c0096c7783
Autor:
Neeta Shrestha, Flavio Max Gall, Cyrille Mathieu, Melanie Michaela Hierweger, Melanie Brügger, Marco P. Alves, Jonathan Vesin, Damiano Banfi, David Kalbermatter, Branka Horvat, Marc Chambon, Gerardo Turcatti, Dimitrios Fotiadis, Rainer Riedl, Philippe Plattet
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Multiple enveloped RNA viruses of the family Paramyxoviridae and Pneumoviridae, like measles virus (MeV), Nipah virus (NiV), canine distemper virus (CDV), or respiratory syncytial virus (RSV), are of high clinical relevance. Each year a huge
Externí odkaz:
https://doaj.org/article/7716b1d33ef34c06b47fd4ee9b13b0ad
Autor:
Lorenzo Sborgi, Johanna Ude, Mathias S. Dick, Jonathan Vesin, Marc Chambon, Gerardo Turcatti, Petr Broz, Sebastian Hiller
Publikováno v:
Cell Stress, Vol 2, Iss 4, Pp 82-90 (2018)
The protein ASC is a central component of most inflammasome complexes, forming functional oligomeric filaments that activate large amounts of pro-caspase-1 for further IL-1β processing and the induction of Gasdermin D-dependent cell death. The centr
Externí odkaz:
https://doaj.org/article/be174553d9cb403f94a5fd589b690b57
Autor:
Neeta Shrestha, Flavio M. Gall, Jonathan Vesin, Marc Chambon, Gerardo Turcatti, Dimitrios Fotiadis, Rainer Riedl, Philippe Plattet
Publikováno v:
Viruses, Vol 13, Iss 1, p 128 (2021)
Canine distemper virus (CDV), a close relative of the human pathogen measles virus (MeV), is an enveloped, negative sense RNA virus that belongs to the genus Morbillivirus and causes severe diseases in dogs and other carnivores. Although the vaccinat
Externí odkaz:
https://doaj.org/article/270bbfc54ac149ec9707568fef0c3b97
Picomole‐Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer
Autor:
Gontran Sangouard, Alessandro Zorzi, Yuteng Wu, Edouard Ehret, Mischa Schüttel, Sangram Kale, Cristina Díaz‐Perlas, Jonathan Vesin, Julien Bortoli Chapalay, Gerardo Turcatti, Christian Heinis
Publikováno v:
Angewandte Chemie International Edition. 60:21702-21707
Macrocyclic compounds are an attractive class of therapeutic ligands against challenging targets, such as protein-protein interactions. However, the development of macrocycles as drugs is hindered by the lack of large combinatorial macrocyclic librar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222b2b27ce24ac853e3a474392789136
https://doi.org/10.1002/anie.202107815
https://doi.org/10.1002/anie.202107815
Autor:
Gerardo Turcatti, Julien Bortoli Chapalay, Alessandro Angelini, Kaycie Deyle, Sangram S. Kale, Jonathan Vesin, Alessandro Zorzi, Carl Leonard Stenbratt, Christian Heinis, Laura Cendron, Ganesh Kumar Mothukuri
Publikováno v:
Chemical Science
Macrocycles provide an attractive modality for drug development, but generating ligands for new targets is hampered by the limited availability of large macrocycle libraries. We have established a solution-phase macrocycle synthesis strategy in which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06732fe4f424a7d1a877525c70164382
http://europepmc.org/articles/PMC8163216
http://europepmc.org/articles/PMC8163216
Autor:
Flavio M. Gall, Philippe Plattet, Marc Chambon, Neeta Shrestha, Jonathan Vesin, Rainer Riedl, Gerardo Turcatti, Dimitrios Fotiadis
Publikováno v:
Viruses
Shrestha, Neeta; Gall, Flavio M; Vesin, Jonathan; Chambon, Marc; Turcatti, Gerardo; Fotiadis, Dimitrios; Riedl, Rainer; Plattet, Philippe (2021). Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity. Viruses, 13(1) Molecular Diversity Preservation International MDPI 10.3390/v13010128
Volume 13
Issue 1
Viruses, Vol 13, Iss 128, p 128 (2021)
Shrestha, Neeta; Gall, Flavio M; Vesin, Jonathan; Chambon, Marc; Turcatti, Gerardo; Fotiadis, Dimitrios; Riedl, Rainer; Plattet, Philippe (2021). Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity. Viruses, 13(1) Molecular Diversity Preservation International MDPI 10.3390/v13010128
Volume 13
Issue 1
Viruses, Vol 13, Iss 128, p 128 (2021)
Canine distemper virus (CDV), a close relative of the human pathogen measles virus (MeV), is an enveloped, negative sense RNA virus that belongs to the genus Morbillivirus and causes severe diseases in dogs and other carnivores. Although the vaccinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc01aea72ea759e333309402c33ef428
http://europepmc.org/articles/PMC7831055
http://europepmc.org/articles/PMC7831055
Autor:
Gerardo Turcatti, Melanie Brügger, Neeta Shrestha, Marc Chambon, Melanie M. Hierweger, Jonathan Vesin, Branka Horvat, Cyrille Mathieu, Dimitrios Fotiadis, Flavio M. Gall, Philippe Plattet, Marco P. Alves, Rainer Riedl, Damiano Banfi, David Kalbermatter
Publikováno v:
mBio
mBio, 2021, 12 (6), pp.390-402. ⟨10.1128/mBio.02621-21⟩
mBio, Vol 12, Iss 6 (2021)
Shrestha, Neeta; Gall, Flavio Max; Mathieu, Cyrille; Hierweger, Melanie Michaela; Brügger, Melanie; Alves, Marco P.; Vesin, Jonathan; Banfi, Damiano; Kalbermatter, David; Horvat, Branka; Chambon, Marc; Turcatti, Gerardo; Fotiadis, Dimitrios; Riedl, Rainer; Plattet, Philippe (2021). Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier. mBio, 12(6), e0262121. American Society for Microbiology 10.1128/mBio.02621-21
mBio, 2021, 12 (6), pp.390-402. ⟨10.1128/mBio.02621-21⟩
mBio, Vol 12, Iss 6 (2021)
Shrestha, Neeta; Gall, Flavio Max; Mathieu, Cyrille; Hierweger, Melanie Michaela; Brügger, Melanie; Alves, Marco P.; Vesin, Jonathan; Banfi, Damiano; Kalbermatter, David; Horvat, Branka; Chambon, Marc; Turcatti, Gerardo; Fotiadis, Dimitrios; Riedl, Rainer; Plattet, Philippe (2021). Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier. mBio, 12(6), e0262121. American Society for Microbiology 10.1128/mBio.02621-21
Multiple enveloped RNA viruses of the family Paramyxoviridae and Pneumoviridae, like measles virus (MeV), Nipah virus (NiV), canine distemper virus (CDV), or respiratory syncytial virus (RSV), are of high clinical relevance. Each year a huge number o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0155abfd8d245019aa9b3ffb08d825e
https://cnrs.hal.science/hal-03777054/document
https://cnrs.hal.science/hal-03777054/document
Autor:
Marc Chambon, Julien Bortoli, Chieh Jason Chou, Gerardo Turcatti, Elena A. Goun, Arkadiy A. Bazhin, Jonathan Vesin, James W. Collins
Aminopeptidases, such as dipeptidyl peptidase 4 (DPP-4, CD26), are potent therapeutic targets for pharmacological interventions because they play key roles in many important pathological pathways. To analyze amino-peptidase activity in vitro (includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b40c1351455e64d7cebdcfb2e0edf6e
https://infoscience.epfl.ch/record/263413
https://infoscience.epfl.ch/record/263413