Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jonathan U. Harrison"'
Autor:
Cédric Castrogiovanni, Alessio V. Inchingolo, Jonathan U. Harrison, Damian Dudka, Onur Sen, Nigel J. Burroughs, Andrew D. McAinsh, Patrick Meraldi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Microtubules are built from GDP-tubulin lattices with small GTP caps at their plus-ends. Here, the authors reveal that microtubules that attach to kinetochores in mitosis contain, in addition to the GTP-cap and the GDP-lattices, a dynamic micron-size
Externí odkaz:
https://doaj.org/article/7374639fc1bf4c5e9e3d04d7bba621f4
Autor:
Tsvetelina E. Germanova, Emanuele Roscioli, Jonathan U. Harrison, Andrew D. McAinsh, Nigel J. Burroughs
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100774- (2021)
Summary: This protocol measures the 3D Euclidean distance (Δ3D) between two/three fluorescently labeled kinetochore components in fixed samples using Kinetochore Delta software (KiDv1.0.1, MATLAB based). Overestimation of mean Δ3D is corrected thro
Externí odkaz:
https://doaj.org/article/7c410bd5af754cd2836e928d7012fddf
Motivation Lattice light-sheet microscopy (LLSM) is revolutionizing cell biology since it enables fast, high-resolution extended imaging in three dimensions combined with a drastic reduction in photo-toxicity and bleaching. However, analysis of such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000821e2ae0c8e00244052fe3a941c6d
http://wrap.warwick.ac.uk/165825/1/WRAP-Kinetochore-tracking-3D-lattice-light-sheet-imaging-data-KiT-2022.pdf
http://wrap.warwick.ac.uk/165825/1/WRAP-Kinetochore-tracking-3D-lattice-light-sheet-imaging-data-KiT-2022.pdf
Testing Models of mRNA Localization Reveals Robustness Regulated by Reducing Transport between Cells
Publikováno v:
Biophys J
Robust control of gene expression in both space and time is of central importance in the regulation of cellular processes, and for multicellular development. However, the mechanisms by which robustness is achieved are generally not identified or well
Mitotic chromosome segregation is a self-organising process that achieves high fidelity separation of 46 duplicated chromosomes into two daughter cells. Chromosomes must be captured by the microtubule-based spindle, aligned at the spindle equator whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6f6a84ed3215f910aa3f7d28f0bb244
https://doi.org/10.1101/2021.12.16.472953
https://doi.org/10.1101/2021.12.16.472953
Autor:
Patrick Meraldi, Nigel J. Burroughs, Cédric Castrogiovanni, Andrew D. McAinsh, Alessio Inchingolo, Jonathan U. Harrison, Damian Dudka, Onur Sen
Current models infer that the microtubule-based mitotic spindle is built from GDP-tubulin with small GTP caps at microtubule plus-ends, including those that attach to kinetochores (K-fibres). Here we reveal that K-fibres additionally contain a dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed1b5eec863bcf2211c24a62e3011ff
https://doi.org/10.1101/2021.07.23.453504
https://doi.org/10.1101/2021.07.23.453504
Publikováno v:
Developmental Cell
Summary Chromosome mis-segregation during mitosis leads to aneuploidy, which is a hallmark of cancer and linked to cancer genome evolution. Errors can manifest as “lagging chromosomes” in anaphase, although their mechanistic origins and likelihoo
Chromosome mis-segregation during mitosis leads to daughter cells with deviant karyotypes (aneuploidy) and an increased mutational burden through chromothripsis of mis-segregated chromosomes. The rate of mis-segregation and the aneuploidy state are h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::436998be3b4f7ab2fe77bdf463038ffb
https://doi.org/10.1101/2021.03.30.436326
https://doi.org/10.1101/2021.03.30.436326
Autor:
Ruth E. Baker, Jonathan U. Harrison
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0236954 (2020)
PLoS ONE, Vol 15, Iss 8, p e0236954 (2020)
To infer the parameters of mechanistic models with intractable likelihoods, techniques such as approximate Bayesian computation (ABC) are increasingly being adopted. One of the main disadvantages of ABC in practical situations, however, is that param
Autor:
Jonathan U Harrison, Ruth E Baker
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236954 (2020)
To infer the parameters of mechanistic models with intractable likelihoods, techniques such as approximate Bayesian computation (ABC) are increasingly being adopted. One of the main disadvantages of ABC in practical situations, however, is that param
Externí odkaz:
https://doaj.org/article/444a208db9594415be8c95c0f20bc0f8