Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jonathan Trujillo Viera"'
Autor:
Jonathan Trujillo Viera, Rabih El-Merahbi, Bernhard Nieswandt, David Stegner, Grzegorz Sumara
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157607 (2016)
Obesity is a major risk factor predisposing to the development of peripheral insulin resistance and type 2 diabetes (T2D). Elevated food intake and/or decreased energy expenditure promotes body weight gain and acquisition of adipose tissue. Number of
Externí odkaz:
https://doaj.org/article/dc97c62dccb448258f2a0054c4661ea4
Autor:
Till Karwen, Katarzyna Kolczynska‐Matysiak, Carina Gross, Mona C Löffler, Mike Friedrich, Angel Loza‐Valdes, Werner Schmitz, Magdalena Wit, Filip Dziaczkowski, Andrei Belykh, Jonathan Trujillo‐Viera, Rabih El‐Merahbi, Carsten Deppermann, Sameena Nawaz, Benoit Hastoy, Agnieszka Demczuk, Manuela Erk, Mariusz R Wieckowski, Patrik Rorsman, Katrin G Heinze, David Stegner, Bernhard Nieswandt, Grzegorz Sumara
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 9, Pp 1-23 (2023)
Abstract Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism. P
Externí odkaz:
https://doaj.org/article/974cd37e10194d4682e8df439ae20f8d
Autor:
Magdalena Wit, Jonathan Trujillo‐Viera, Akim Strohmeyer, Martin Klingenspor, Mohammed Hankir, Grzegorz Sumara
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 5, Pp 1-18 (2022)
Abstract The regular overconsumption of energy‐dense foods (rich in lipids and sugars) results in elevated intestinal nutrient absorption and consequently excessive accumulation of lipids in the liver, adipose tissue, skeletal muscles, and other or
Externí odkaz:
https://doaj.org/article/d0335c9cca03450287d7290c9b23c376
Autor:
Jonathan Trujillo‐Viera, Rabih El‐Merahbi, Vanessa Schmidt, Till Karwen, Angel Loza‐Valdes, Akim Strohmeyer, Saskia Reuter, Minhee Noh, Magdalena Wit, Izabela Hawro, Sabine Mocek, Christina Fey, Alexander E Mayer, Mona C Löffler, Ilka Wilhelmi, Marco Metzger, Eri Ishikawa, Sho Yamasaki, Monika Rau, Andreas Geier, Mohammed Hankir, Florian Seyfried, Martin Klingenspor, Grzegorz Sumara
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp 1-20 (2021)
Abstract Lipids are the most energy‐dense components of the diet, and their overconsumption promotes obesity and diabetes. Dietary fat content has been linked to the lipid processing activity by the intestine and its overall capacity to absorb trig
Externí odkaz:
https://doaj.org/article/7c21b9b7b80e406aaf05b383b2b65ed9
Autor:
Angel Loza-Valdes, Rabih El-Merahbi, Toufic Kassouf, Agnieszka Demczuk, Saskia Reuter, Jonathan Trujillo Viera, Till Karwen, Minhe Noh, Mona C. Löffler, Rafael Romero-Becerra, Jorge L. Torres, Miguel Marcos, Guadalupe Sabio, Urszula Wojda, Grzegorz Sumara
Publikováno v:
Biochemical and biophysical research communications. 612
Kinases represent one of the largest druggable families of proteins. Importantly, many kinases are aberrantly activated/de-activated in multiple organs during obesity, which contributes to the development of diabetes and associated diseases. Previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bdabd99c152f783d9afc301f69710c
https://pubmed.ncbi.nlm.nih.gov/35523049
https://pubmed.ncbi.nlm.nih.gov/35523049
Autor:
Andreas Schlosser, Angel Loza-Valdes, Jonathan Trujillo-Viera, Toufic Kassouf, Alexander E. Mayer, Michael Leitges, Grzegorz Sumara, Filip Dziaczkowski, Werner Schmitz
Publikováno v:
Life Science Alliance
Protein kinase D3 (PKD3) regulates hepatic metabolism in a PKA-dependent manner and reveals many other putative PKD3 targets in the liver.
Members of the protein kinase D (PKD) family (PKD1, 2, and 3) integrate hormonal and nutritional inputs to
Members of the protein kinase D (PKD) family (PKD1, 2, and 3) integrate hormonal and nutritional inputs to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59508ade8b42cfbd3b916450c194839e
Autor:
Werner Schmitz, Grzegorz Sumara, Angel Loza-Valdes, Alexander E. Mayer, Jonathan Trujillo Viera, Michael Leitges, Andreas Schlosser
SummaryMembers of the Protein Kinase D (PKD) family (PKD1, 2, and 3) integrate hormonal and nutritional inputs to regulate complex cellular metabolism. Despite the fact that a number of functions have been annotated to particular PKDs, their molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed3a8a49b4ef4d5db9f2c8b35d32c79
https://doi.org/10.1101/2020.07.20.211474
https://doi.org/10.1101/2020.07.20.211474
Autor:
Rabih El-Merahbi, Grzegorz Sumara, Jonathan Trujillo Viera, David Stegner, Bernhard Nieswandt
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0157607 (2016)
PLoS ONE, Vol 11, Iss 6, p e0157607 (2016)
Obesity is a major risk factor predisposing to the development of peripheral insulin resistance and type 2 diabetes (T2D). Elevated food intake and/or decreased energy expenditure promotes body weight gain and acquisition of adipose tissue. Number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d9f898ca25e7de2a52d6c7f3c29356
https://opus.bibliothek.uni-wuerzburg.de/files/17972/Viera_Plos_One.PDF
https://opus.bibliothek.uni-wuerzburg.de/files/17972/Viera_Plos_One.PDF
Autor:
Alexander E. Mayer, Carsten P. Ade, Grzegorz Sumara, Rabih El-Merahbi, Jonathan Trujillo Viera, Angel Loza Valdes, Katarzyna Kolczynska, Till Karwen, Manuela Erk, Mona C. Löffler, Martin Eilers, Saskia Reuter
Publikováno v:
Genes & Development
Obesity-induced diabetes affects >400 million people worldwide. Uncontrolled lipolysis (free fatty acid release from adipocytes) can contribute to diabetes and obesity. To identify future therapeutic avenues targeting this pathway, we performed a hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec63724db00b74cee8839f7c30f6cb69
Autor:
Almut Schulze, Rabih El-Merahbi, Manuela Erk, Jonathan Trujillo Viera, Grzegorz Sumara, Martin Eilers, Miguel Marcos, Werner Schmitz, Nuria Matesanz, Guadalupe Sabio, Carsten P. Ade, Angel Loza Valdes, Alexander E. Mayer, Mona C. Löffler, Jorge L Torres, Anja Slotta, Till Karwen, Sudha Janaki-Raman
Publikováno v:
The EMBO Journal
Nutrient overload in combination with decreased energy dissipation promotes obesity and diabetes. Obesity results in a hormonal imbalance, which among others activates G protein-coupled receptors utilizing diacylglycerol (DAG) as secondary messenger.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f3b9b4b4a5375386e0bfd81eee5b1c