Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jonathan T. Fleming"'
Autor:
Charles H. Williams, Jonathan E. Hempel, Jijun Hao, Audrey Y. Frist, Michelle M. Williams, Jonathan T. Fleming, Gary A. Sulikowski, Michael K. Cooper, Chin Chiang, Charles C. Hong
Publikováno v:
Cell Reports, Vol 11, Iss 1, Pp 43-50 (2015)
Hedgehog (Hh) signaling plays an integral role in vertebrate development, and its dysregulation has been accepted widely as a driver of numerous malignancies. While a variety of small molecules target Smoothened (Smo) as a strategy for Hh inhibition,
Externí odkaz:
https://doaj.org/article/47e8bc09c7cc428c932ffb7a41a5037b
Autor:
Chin Chiang, Andrzej A. Dlugosz, Alexandre N. Ermilov, Hernán Correa, Bingshan Li, Quan Wang, Shilin Zhao, Yan Guo, Lei Chen, Emily Brignola, Jonathan T. Fleming
Figure S1. PCG2 tumors showed persistent Hh pathway activity, while SmoM2 disrupts brain morphogenesis. Figure S2. PCG2 gene expression and ultrastructural features. Figure S3. Characterization of PCG2M226 cells. Figure S4. Phenotypic divergence betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b9775652a7a8df8daa5754a2240563
https://doi.org/10.1158/1541-7786.22513440.v1
https://doi.org/10.1158/1541-7786.22513440.v1
Autor:
Wen Li, Lei Chen, Jonathan T. Fleming, Emily Brignola, Kirill Zavalin, Andre Lagrange, Tonia Rex, Shane A. Heiney, Gregory J. Wojaczynski, Javier F. Medina, Chin Chiang
Publikováno v:
J Neurosci
Cerebellar inhibitory interneurons are important regulators of neural circuit activity for diverse motor and nonmotor functions. The molecular layer interneurons (MLIs), consisting of basket cells (BCs) and stellate cells (SCs), provide dendritic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ef3ccea585709d8efd8a23cee03c67
https://europepmc.org/articles/PMC9236294/
https://europepmc.org/articles/PMC9236294/
Autor:
Ying Litingtung, Jonathan T. Fleming, Chin Chiang, Kaitlyn E. Ryan, Frances Y. Cheng, Patrick S. Kim, Emily Brignola
Publikováno v:
Developmental Biology. 432:165-177
Cerebellar growth and foliation require the Hedgehog-driven proliferation of granule cell precursors (GCPs) in the external granule layer (EGL). However, that increased or extended GCP proliferation generally does not elicit ectopic folds suggests th
Autor:
Sudan N. Loganathan, Yufang Ma, Jonathan T. Fleming, Chin Chiang, Scott C. Borinstein, Yan Guo, Jialiang Wang, Nan Tang
Publikováno v:
Oncotarget
// Sudan N. Loganathan 1, 2 , Nan Tang 3 , Jonathan T. Fleming 4 , Yufang Ma 5 , Yan Guo 6 , Scott C. Borinstein 7 , Chin Chiang 4 , Jialiang Wang 1, 2, 5, 6 1 Department of Neuroscience and Pharmacology, Meharry Medical College, Nashville, TN, USA 2
Neuronal-glial relationships play a critical role in the maintenance of central nervous system architecture and neuronal specification. A deeper understanding of these relationships can elucidate cellular cross-talk capable of sustaining proper devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbde6f1413746febbc5f9a1656c8cd1
https://europepmc.org/articles/PMC6014626/
https://europepmc.org/articles/PMC6014626/
Autor:
Jonathan T. Fleming, Andrzej A. Dlugosz, Chin Chiang, Quan Wang, Emily Brignola, Alexandre N. Ermilov, Lei Chen, Hernan Correa, Yan Guo, Shilin Zhao, Bingshan Li
Publikováno v:
Molecular cancer research : MCR. 17(5)
Aberrant activation of the Hedgehog signaling pathway has been linked to the formation of numerous cancer types, including the myogenic soft tissue sarcoma, embryonal rhabdomyosarcoma (eRMS). Here, we report PCG2, a novel mouse model in which human G
Autor:
Chin Chiang, Charles H. Williams, Charles C. Hong, Gary A. Sulikowski, Audrey Y. Frist, Michael K. Cooper, Michelle M. Williams, Jijun Hao, Jonathan T. Fleming, Jonathan E. Hempel
Publikováno v:
Cell Reports, Vol 11, Iss 1, Pp 43-50 (2015)
SummaryHedgehog (Hh) signaling plays an integral role in vertebrate development, and its dysregulation has been accepted widely as a driver of numerous malignancies. While a variety of small molecules target Smoothened (Smo) as a strategy for Hh inhi
Autor:
Jianjian Sun, Terri T. Ni, Wenyan Li, Susan P.C. Cole, Haiyan Wan, Anna Papierniak, Daqing Jin, Bin Zhou, Guangju Yu, Tao P. Zhong, Gwenaëlle Conseil, Satish Cheepala, John D. Schuetz, Jonathan T. Fleming, Chin Chiang, Jeffrey D. Amack, Jarema Malicki, Iain A. Drummond
Publikováno v:
Nature cell biology
Cilia are microtubule-based organelles that mediate signal transduction in a variety of tissues. Despite their importance, the signalling cascades that regulate cilium formation remain incompletely understood. Here we report that prostaglandin signal
Autor:
Xi Huang, Tatiana Ketova, Michael K. Cooper, Jonathan T. Fleming, Jiang Liu, Chin Chiang, Vandana K. Grover, Ying Litingtung
Publikováno v:
Proceedings of the National Academy of Sciences. 107:8422-8427
Cerebellar neurons are generated from two germinal neuroepithelia: the ventricular zone (VZ) and rhombic lip. Signaling mechanisms that maintain the proliferative capacity of VZ resident progenitors remain elusive. We reveal that Sonic hedgehog (Shh)