Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jonathan T Sockolosky"'
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102566 (2014)
We explore a strategy to substantially increase the half-life of recombinant proteins by genetic fusion to FcIII, a 13-mer IgG-Fc domain binding peptide (IgGBP) originally identified by DeLano and co-workers at Genentech [DeLano WL, et al. (2000) Sci
Externí odkaz:
https://doaj.org/article/e516049d6443427daa8548bf20595ec6
Autor:
Matthew G. Romei, Brandon Leonard, Zachary B. Katz, Daniel Le, Yanli Yang, Eric S. Day, Christopher W. Koo, Preeti Sharma, Jack Bevers III, Ingrid Kim, Huiguang Dai, Farzam Farahi, May Lin, Andrey S. Shaw, Gerald Nakamura, Jonathan T. Sockolosky, Greg A. Lazar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The ability to leverage antibodies to agonize disease relevant biological pathways has tremendous potential for clinical investigation. Yet while antibodies have been successful as antagonists, immune mediators, and targeting agents, they ar
Externí odkaz:
https://doaj.org/article/17d263c9cfc746cea0b227c5efde646d
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Existing in vivo mutagenesis tools are limited by low mutation diversity and mutation rates. Here the authors present TRIDENT for targeted, continual and inducible diversification of genes of interest using deaminases fused to T7 RNA polymerase.
Externí odkaz:
https://doaj.org/article/a09839f69fe344c5b0b778bd2bc12f32
Autor:
Tracy C. Kuo, Amy Chen, Ons Harrabi, Jonathan T. Sockolosky, Anli Zhang, Emma Sangalang, Laura V. Doyle, Steven E. Kauder, Danielle Fontaine, Sangeetha Bollini, Bora Han, Yang-Xin Fu, Janet Sim, Jaume Pons, Hong I. Wan
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-19 (2020)
Abstract Background Signal regulatory protein α (SIRPα) is a myeloid-lineage inhibitory receptor that restricts innate immunity through engagement of its cell surface ligand CD47. Blockade of the CD47–SIRPα interaction synergizes with tumor-spec
Externí odkaz:
https://doaj.org/article/aafee68f22694b6fb3c27f80eac48cb0
Autor:
Qian Zhang, Morgan E. Hresko, Lora K. Picton, Leon Su, Michael J. Hollander, Selene Nunez-Cruz, Zheng Zhang, Charles-Antoine Assenmacher, Jonathan T. Sockolosky, K. Christopher Garcia, Michael C. Milone
Publikováno v:
Sci Transl Med
Interleukin (IL)-2 is a central T cell cytokine that promotes T cell proliferation and effector function; however, toxicity due to its pluripotency limits its application to enhance CAR T cell immunotherapy. Previously, mouse IL-2 and its cognate rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399cd08790cb20fd80b9711eb9cc5bae
https://doi.org/10.1126/scitranslmed.abg6986
https://doi.org/10.1126/scitranslmed.abg6986
Publikováno v:
Advanced Drug Delivery Reviews. 189:114521
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e637158d35f06ab121d6637f1d7938b
https://doi.org/10.1016/j.addr.2022.114521
https://doi.org/10.1016/j.addr.2022.114521
Autor:
Chen Amy Shaw-Ru, Anup Madan, Janet Sim, Ons Harrabi, Tracy C. Kuo, Hong Wan, Ardian S Wibowo, Shelley Izquierdo, Emma Sangalang, Darlene Pedersen, Josh Carter, Steven E. Kauder, Jonathan T. Sockolosky, Jaume Pons, Harriman William Don, Laura Doyle
Publikováno v:
mAbs
Targeting the CD47-signal-regulatory protein α (SIRPα) pathway represents a novel therapeutic approach to enhance anti-cancer immunity by promoting both innate and adaptive immune responses. Unlike CD47, which is expressed ubiquitously, SIRPα expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b6e62d7e10586ce646d15c3a63cebd
http://europepmc.org/articles/PMC6748616
http://europepmc.org/articles/PMC6748616
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Random mutagenesis is a technique used to generate diversity and engineer biological systems. In vivo random mutagenesis generates diversity directly in a host organism, enabling applications such as lineage tracing, continuous evolution, and protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c09761b71eb110c5fc0cc403d2127bb
https://doi.org/10.1038/s41467-021-21876-z
https://doi.org/10.1038/s41467-021-21876-z
Autor:
Patrick G. Holder, Shion A. Lim, Christine S. Huang, Preeti Sharma, Yavuz S. Dagdas, Beyza Bulutoglu, Jonathan T. Sockolosky
Publikováno v:
Advanced Drug Delivery Reviews. 182:114112
Cytokines are a class of potent immunoregulatory proteins that are secreted in response to various stimuli and act locally to regulate many aspects of human physiology and disease. Cytokines play important roles in cancer initiation, progression, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76b66258b059444af35960b2bb329ad
https://doi.org/10.1016/j.addr.2022.114112
https://doi.org/10.1016/j.addr.2022.114112
Autor:
M D Mathias, K S Tan, Kenan Christopher Garcia, C Liu, David A. Scheinberg, A Y Chang, Jonathan T. Sockolosky
Publikováno v:
Leukemia
CD47 blockade enhances therapeutic activity of TCR mimic antibodies to ultra-low density cancer epitopes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acb3a124a22a52f56fb79999ee69b49
https://doi.org/10.1038/leu.2017.223
https://doi.org/10.1038/leu.2017.223