Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jonathan T Skare"'
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162501 (2016)
Borrelia burgdorferi is a spirochetal bacterium transmitted by the Ixodes tick that causes Lyme disease in humans due to its ability to evade the host immune response and disseminate to multiple immunoprotective tissues. The pathogen undergoes dynami
Externí odkaz:
https://doaj.org/article/714d758d84684d699067cab506a3cb21
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5412 (2009)
BBK32 is a surface expressed lipoprotein and fibronectin (Fn)-binding microbial surface component recognizing adhesive matrix molecule (MSCRAMM) of Borrelia burgdorferi, the causative agent of Lyme disease. Previous studies from our group showed that
Externí odkaz:
https://doaj.org/article/39810508b8d944f5a5496e0bd1aa1e6f
Publikováno v:
Journal of Bacteriology. 189:437-445
The etiologic agent of Lyme disease, Borrelia burgdorferi , must adapt to the distinct environments of its arthropod vector and mammalian host during its complex life cycle. B. burgdorferi alters gene expression and protein synthesis in response to t
Publikováno v:
Microbiology. 152:2599-2609
Borrelia burgdorferi regulates gene expression in response to environmental conditions, including temperature, pH, redox potential and host factors. B. burgdorferi encodes a PerR homologue designated BosR, which presumably serves as a global regulato
Autor:
Maria Labandeira-Rey, Magnus Höök, Jerome P. Trzeciakowski, M. Dolores Esteve-Gassent, Jung Hwa Kim, Jonathan T. Skare, Janakiram Seshu
Publikováno v:
Molecular Microbiology. 59:1591-1601
Borrelia burgdorferi, the aetiological agent of Lyme disease, utilizes multiple adhesins to interact with both the arthropod vector and mammalian hosts it colonizes. One such adhesive molecule is a surface-exposed fibronectin-binding lipoprotein, des
Autor:
Julie A. Boylan, Jonathan T. Skare, Frank C. Gherardini, Janakiram Seshu, Jenny A. Hyde, Kristen Swingle
Publikováno v:
Molecular Microbiology. 54:1352-1363
Borrelia burgdorferi, the aetiologic agent of Lyme disease, modulates gene expression in response to changes imposed by its arthropod vector and mammalian hosts. As reactive oxygen species (ROS) are known to vary in these environments, we asked how B
Publikováno v:
Infection and Immunity. 72:1580-1586
The Lyme disease spirochete, Borrelia burgdorferi , encounters many environmental signals as it cycles between the arthropod vector and mammalian hosts, including temperature, pH, and other host factors. To test the possibility that dissolved oxygen
Publikováno v:
Infection and Immunity. 71:4608-4613
The 25-kb linear plasmid lp25 and one of the 28-kb linear plasmids (lp28-1) are required for experimental infection inBorrelia burgdorferi, the etiologic agent of Lyme disease. The loss of these plasmids either eliminates infectivity (lp25) or signif
Publikováno v:
Infection and Immunity. 69:1409-1419
We have previously described the expression cloning of nine Borrelia burgdorferi antigens, using rabbit serum enriched for antibodies specific for infection-associated antigens, and determined that seven of these antigens were associated with infecti
Publikováno v:
Infection and Immunity. 69:446-455
Previous reports indicated a correlation between loss of plasmids and decreased infectivity of Borrelia burgdorferi strain B31, suggesting that plasmids may encode proteins that are required for pathogenesis. In this study, we expand on this correlat