Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jonathan T Beech"'
Publikováno v:
Journal of Autoimmunity. 31:59-65
Competitive capture is a process by which different determinants of an unfolding antigen compete for binding to the same MHC class II molecule. The “winning” determinant is then dominantly displayed. For self antigens, T cells with specificity fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0aed31049210c135d434b7f1e20bc7
https://doi.org/10.1016/j.jaut.2008.02.004
https://doi.org/10.1016/j.jaut.2008.02.004
Autor:
Jonathan T Beech, Fionula M. Brennan
Publikováno v:
Current Opinion in Rheumatology. 19:296-301
Purpose of review There have recently been fewer publications describing novel cytokines in rheumatoid arthritis. In the present review we focus on cytokines not previously implicated in contributing to the pathogenesis of rheumatoid arthritis. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40440b57bd6cce9494e31f90971a844f
https://doi.org/10.1097/bor.0b013e32805e87f1
https://doi.org/10.1097/bor.0b013e32805e87f1
Autor:
Stephen S. Wilson, Brian Pedersen, Emanual Michael Maverakis, Anthony Quinn, Eli E. Sercarz, Jonathan T. Beech
Publikováno v:
The Journal of Experimental Medicine
All adult BALB/c mice immunized with hen egg white lysozyme (HEL) or its dominant determinant, peptide (p)106–116, mount a T cell response using a “public” Vβ8.2Jβ1.5 T cell clone. Neonatal exposure to tolerance-inducing doses of antigen can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ea580e2f187312474622b1680d950a
http://europepmc.org/articles/PMC2195845
http://europepmc.org/articles/PMC2195845
Autor:
Oskar Adolfsson, Marc Feldmann, Jonathan T Beech, J. Perry Hall, Brenda A. Carito, Brian M. J. Foxwell, David Winkler, Jun Kuai, Jagdeep Nanchahal, Debra D Pittman, Andrew A. Hill, Tom Brown, Margot O'Toole, Ken Dower, Bernard Gregory, Jeffrey L. Feldman, Fionula M. Brennan, Renee Ramsey, Yahya Kurdi, Lih-Ling Lin, Kathleen M. Shields
Publikováno v:
Scopus-Elsevier
Objectives. To investigate the expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) in the synovium of human RA patients as well as the level of soluble TREM-1 in the plasma of RA patients. Methods. Twenty-four RA syno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f759d204e0c5e05a6a069100291724c
http://ora.ox.ac.uk/objects/uuid:779d1245-eb3a-429b-860b-0508bda70438
http://ora.ox.ac.uk/objects/uuid:779d1245-eb3a-429b-860b-0508bda70438
Autor:
Jonathan T, Beech, Fionula M, Brennan
Publikováno v:
Methods in molecular medicine. 135
In rheumatoid arthritis (RA), the synovium represents the predominant site of inflammation and joint destruction and is regarded as the key organ involved in disease pathogenesis. It has been studied in different ways over the last 30 yr, yielding in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f14ab0e5bc29a3f40c65a82b66ae0f43
https://pubmed.ncbi.nlm.nih.gov/17951655
https://pubmed.ncbi.nlm.nih.gov/17951655
Autor:
Marc Feldmann, Debra D. Pittman, Jonathan T Beech, Brian M. J. Foxwell, Jennifer A. Stover, Jeffrey L. Feldman, William L. Trepicchio, Christopher J Edwards, Kathleen M. Shields, Glenn Larsen, Fionula M. Brennan
Publikováno v:
Molecular medicine (Cambridge, Mass.). 13(1-2)
Rheumatoid arthritis (RA) is a chronic inflammatory arthritis. Currently, diagnosis of RA may take several weeks, and factors used to predict a poor prognosis are not always reliable. Gene expression in RA may consist of a unique signature. Gene expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f17579c70bb6edaafc9e92ce7d3a9ce
http://ora.ox.ac.uk/objects/uuid:0ef1435f-ab28-417f-acd7-a24be1a44d91
http://ora.ox.ac.uk/objects/uuid:0ef1435f-ab28-417f-acd7-a24be1a44d91
Autor:
Fionula M. Brennan, Jonathan T Beech
Publikováno v:
Arthritis Research ISBN: 9781588293442
In rheumatoid arthritis (RA), the synovium represents the predominant site of inflammation and joint destruction and is regarded as the key organ involved in disease pathogenesis. It has been studied in different ways over the last 30 yr, yielding in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0ef497cdbfe8c395d9c61b44136691
https://doi.org/10.1007/978-1-59745-401-8_7
https://doi.org/10.1007/978-1-59745-401-8_7
Autor:
Marc Feldmann, Abigail E. Hunt, Louise A. Hayes, Agnes Denys, Cathleen J. Ciesielski, Jamie Campbell, Nicole J. Horwood, Brian M. J. Foxwell, Fionula M. Brennan, Jonathan T Beech
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 173(11)
TNF-α is a key factor in a variety of inflammatory diseases. This study examines the role of p38 MAPK in the regulation of TNF-α in primary human cells relevant to inflammation, e.g., macrophages and rheumatoid synovial cells. Using a dominant nega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13934ec645d05f0e279759054999f6eb
http://ora.ox.ac.uk/objects/uuid:5a8741a2-ac79-4f99-8d52-cfb627849216
http://ora.ox.ac.uk/objects/uuid:5a8741a2-ac79-4f99-8d52-cfb627849216
Autor:
Magdalena Pertyńska-Marczewska, Robin Wait, Serafim Kiriakidis, Jonathan T Beech, Ewa M. Paleolog, Marc Feldmann
Publikováno v:
Cytokine. 28(1)
Glucose can react non-enzymatically with amino groups of, for example, proteins, to yield derivatives termed advanced glycation end products (AGE), which contribute to many chronic progressive diseases associated with microvascular complications. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaaf06167b31d3a8ec31a9d0573fb57
https://pubmed.ncbi.nlm.nih.gov/15341924
https://pubmed.ncbi.nlm.nih.gov/15341924
Autor:
Emanual Michael Maverakis, Quoc Thai, Akio Ametani, Peter van den Elzen, Eli E. Sercarz, Luis H. Macias, Doug Ethell, Anthony T. Campagnoni, Celia W. Campagnoni, David B. Stevens, Richard Mendoza, Laurent Brossay, Alessandro Sette, Jonathan T. Beech
It is not clear why the N-terminal autoantigenic determinant of myelin basic protein (MBP), Ac1–9, is dominant in the B1O.PL (H-2 u ) mouse, given its weak I-A u -MHC binding affinity. Similarly, how do high-affinity T cells specific for this deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da8fee45261865b34d5727002f2fb0d
https://europepmc.org/articles/PMC154347/
https://europepmc.org/articles/PMC154347/