Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jonathan Sumner"'
Autor:
Stacey E. Chin, Christina Schindler, Lisa Vinall, Roger B. Dodd, Lisa Bamber, Sandrine Legg, Anna Sigurdardottir, D. Gareth Rees, Tim I. M. Malcolm, Samantha J. Spratley, Cecilia Granéli, Jonathan Sumner, Natalie J. Tigue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Chemical inducer of dimerization (CID) modules can be used effectively as molecular switches to control biological processes, and thus there is significant interest within the synthetic biology community in identifying novel CID systems. To
Externí odkaz:
https://doaj.org/article/1c4fb2f0a98149f7bb083c8fbced398e
Autor:
Sandra Wimberger, Nina Akrap, Mike Firth, Johan Brengdahl, Susanna Engberg, Marie K. Schwinn, Michael R. Slater, Anders Lundin, Pei-Pei Hsieh, Songyuan Li, Silvia Cerboni, Jonathan Sumner, Burcu Bestas, Bastian Schiffthaler, Björn Magnusson, Silvio Di Castro, Preeti Iyer, Mohammad Bohlooly-Y, Thomas Machleidt, Steve Rees, Ola Engkvist, Tyrell Norris, Elaine B. Cadogan, Josep V. Forment, Saša Šviković, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Marcello Maresca
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration and generation of unintended muta
Externí odkaz:
https://doaj.org/article/4bb0c69502654c769c92ef8642d93a46
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT The HIV-1 Vpu protein is expressed late in the virus lifecycle to promote infectious virus production and avoid innate and adaptive immunity. This includes the inhibition of the NF-κB pathway which, when activated, leads to the induction of
Externí odkaz:
https://doaj.org/article/c9e6208077874a24822b36f14b2f55a7
Publikováno v:
Nutrition and Health. 28:527-542
Background: To examine the relationship of vitamin B12 and folate concentrations to cognitive function, fatigue measures, physical function, quality of life (patient-centred outcomes) and homocysteine plasma concentrations (intermediate marker of cob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bd3899390e7018f6cd779726ec13c9
https://doi.org/10.1177/02601060221080240
https://doi.org/10.1177/02601060221080240
Autor:
Sandra Wimberger, Nina Akrap, Mike Firth, Johan Brengdahl, Susanna Engberg, Marie K. Schwinn, Michael R. Slater, Anders Lundin, Pei-Pei Hsieh, Songyuan Li, Silvia Cerboni, Jonathan Sumner, Burcu Bestas, Bastian Schiffthaler, Björn Magnusson, Silvio Di Castro, Preeti Iyer, Bohlooly-Y Mohammad, Thomas Machleidt, Steve Rees, Ola Engkvist, Tyrell Norris, Elaine Cadogan, Josep V. Forment, Saša Šviković, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Marcello Maresca
Genome editing tools, especially CRISPR/Cas9-based strategies, have transformed biomedical research and opened opportunities for developing curative treatments for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08601f80723c09f5557274e0ab558c2
https://doi.org/10.1101/2022.12.15.520396
https://doi.org/10.1101/2022.12.15.520396
The HIV-1 Vpu protein is expressed late in the virus lifecycle to promote infectious virus production and avoid innate and adaptive immunity. This includes the inhibition of the NF-κB pathway which, when activated, leads to the induction of inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85f8687085129ae36e01b749e768c2d3
https://doi.org/10.1101/2022.11.30.518636
https://doi.org/10.1101/2022.11.30.518636
Autor:
Aldana Alnesf, Michael Ridley, Sylvine Lalnunhlimi, Leonie S. Taams, Aoife M O'Byrne, Jonathan Sumner, Paul Lavender, Ceri A. Roberts, Kathryn J. A. Steel, Giovanni A M Povoleri, Veerle Fleskens
Publikováno v:
The Journal of Immunology Author Choice
Key Points Anti-TNF maintains IL10 expression in CD4+ T cells at the transcriptional level. IKZF3 is enriched in IL-10+ CD4+ T cells; degrading IKZF3 disrupts IL-10 production. Overexpression of IKZF3 does not drive IL10 or activate local enhancers.<
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130fda1c2360c73ee4406a17179ea030
https://doi.org/10.4049/jimmunol.1901283
https://doi.org/10.4049/jimmunol.1901283
Autor:
Nicholas J, Matheson, Jonathan, Sumner, Kim, Wals, Radu, Rapiteanu, Michael P, Weekes, Raphael, Vigan, Julia, Weinelt, Michael, Schindler, Robin, Antrobus, Ana S H, Costa, Christian, Frezza, Clary B, Clish, Stuart J D, Neil, Paul J, Lehner
Publikováno v:
Cell hostmicrobe. 18(4)
Critical cell surface immunoreceptors downregulated during HIV infection have previously been identified using non-systematic, candidate approaches. To gain a comprehensive, unbiased overview of how HIV infection remodels the T cell surface, we took
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c4131ecbdf68e6761c73396cbe0b7cd6
https://pubmed.ncbi.nlm.nih.gov/26567503
https://pubmed.ncbi.nlm.nih.gov/26567503
Publikováno v:
Journal of the American College of Cardiology. 65(10)
Magnetic resonance imaging (MRI) plays a pivotal role in evaluating cardiomyopathies of varying etiology. The main objective of this poster is to illustrate specific cardiac lesion characteristics based on the pattern of delayed contrast enhancement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a323be6d6fb3d553ad93223b32e84be
Autor:
Andrew P. Cope, Hayley G. Evans, Urmas Roostalu, Ceri A. Roberts, Leonie S. Taams, Gina J Walter, Nicola J. Gullick, Jens Gerwien, Dominique Baeten, Frederic Geissmann, Jonathan Sumner, Bruce Kirkham, Klaus Stensgaard Frederiksen
Publikováno v:
Nature communications, 5. Nature Publishing Group
Nature communications
Nature communications
IL-17+ CD4+ T (Th17) cells contribute to the pathogenesis of several human inflammatory diseases. Here we demonstrate that TNF inhibitor (TNFi) drugs induce the anti-inflammatory cytokine IL-10 in CD4+ T cells including IL-17+ CD4+ T cells. TNFi-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6e4a5c43d158c0b365c3d9c8e6e432
https://doi.org/10.1038/ncomms4199
https://doi.org/10.1038/ncomms4199