Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jonathan Strecker"'
Autor:
Chris J. Frangieh, Max E. Wilkinson, Daniel Strebinger, Jonathan Strecker, Michelle L. Walsh, Guilhem Faure, Irina A. Yushenova, Rhiannon K. Macrae, Irina R. Arkhipova, Feng Zhang
Publikováno v:
Mobile DNA, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Eukaryotic retroelements are generally divided into two classes: long terminal repeat (LTR) retrotransposons and non-LTR retrotransposons. A third class of eukaryotic retroelement, the Penelope-like elements (PLEs), has been well-characteriz
Externí odkaz:
https://doaj.org/article/356462f605d44af0b6c59f8127673873
Autor:
Johnny M Tkach, Reuben Philip, Amit Sharma, Jonathan Strecker, Daniel Durocher, Laurence Pelletier
Publikováno v:
eLife, Vol 11 (2022)
Centrosomes act as the main microtubule organizing center (MTOC) in metazoans. Centrosome number is tightly regulated by limiting centriole duplication to a single round per cell cycle. This control is achieved by multiple mechanisms, including the r
Externí odkaz:
https://doaj.org/article/fc695c50222a47249da3873639dc6225
Autor:
Isabella Del Priore, Sai Ma, Jonathan Strecker, Tyler Jacks, Lindsay M. LaFave, Jason D. Buenrostro
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100583- (2021)
Summary: Single-cell ATAC sequencing using combinatorial indexing (sciATAC-seq) enables the identification of chromatin accessibility profiles at single-cell resolution with a dual-barcoding approach during transposition and library construction. Unl
Externí odkaz:
https://doaj.org/article/a5d77e8692f1447982da45153e7cc119
Autor:
Jonathan Strecker, Sara Jones, Balwina Koopal, Jonathan Schmid-Burgk, Bernd Zetsche, Linyi Gao, Kira S. Makarova, Eugene V. Koonin, Feng Zhang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
The Cas12b family of CRISPR nucleases has been underutilized in mammalian cells due to the high temperature requirement of known members. Here the authors engineer BhCas12b to overcome this limitation for robust and specific genome editing applicatio
Externí odkaz:
https://doaj.org/article/e6ea12311957487294bb0381d2fecb20
Autor:
Ian M. Slaymaker, Pablo Mesa, Max J. Kellner, Soumya Kannan, Edward Brignole, Jeremy Koob, Patricia R. Feliciano, Stefano Stella, Omar O. Abudayyeh, Jonathan S. Gootenberg, Jonathan Strecker, Guillermo Montoya, Feng Zhang
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108865- (2021)
Externí odkaz:
https://doaj.org/article/59a71b7f9f9e4a2d9fb08cd9fade6977
Publikováno v:
QRB Discovery, Vol 1 (2020)
Repetitive sequence elements in proteins and nucleic acids are often signatures of adaptive or reprogrammable systems in nature. Known examples of these systems, such as transcriptional activator-like effectors (TALE) and CRISPR, have been harnessed
Externí odkaz:
https://doaj.org/article/f64c64682f984ec485a7b3d3109cf4e4
Autor:
Roxanne Oshidari, Jonathan Strecker, Daniel K. C. Chung, Karan J. Abraham, Janet N. Y. Chan, Christopher J. Damaren, Karim Mekhail
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Following DNA damage, different processes come to action to aid repair. The authors here find that microtubule filaments within the cell nucleus capture and non-randomly mobilize damaged chromatin to mediate DNA repair.
Externí odkaz:
https://doaj.org/article/4320e998628b46a9b1f9a18feb648d85
Autor:
Ian M. Slaymaker, Pablo Mesa, Max J. Kellner, Soumya Kannan, Edward Brignole, Jeremy Koob, Patricia R. Feliciano, Stefano Stella, Omar O. Abudayyeh, Jonathan S. Gootenberg, Jonathan Strecker, Guillermo Montoya, Feng Zhang
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3741-3751.e5 (2019)
Summary: Type VI CRISPR-Cas systems contain programmable single-effector RNA-guided RNases, including Cas13b, one of the four known family members. Cas13b, which has been used for both RNA editing and nucleic acid detection, is unique among type VI C
Externí odkaz:
https://doaj.org/article/bf9da071e1ca429bb1c6fd1d45795839
Autor:
Jonathan Strecker, Sonia Stinus, Mariana Pliego Caballero, Rachel K Szilard, Michael Chang, Daniel Durocher
Publikováno v:
eLife, Vol 6 (2017)
DNA double-strand breaks (DSBs) and short telomeres are structurally similar, yet they have diametrically opposed fates. Cells must repair DSBs while blocking the action of telomerase on these ends. Short telomeres must avoid recognition by the DNA d
Externí odkaz:
https://doaj.org/article/a96124ee321248c39f9a052bc2141edc
Autor:
Jonathan Strecker, F. Esra Demircioglu, David Li, Guilhem Faure, Max E. Wilkinson, Jonathan S. Gootenberg, Omar O. Abudayyeh, Hiroshi Nishimasu, Rhiannon K. Macrae, Feng Zhang
Publikováno v:
Science
In prokaryotes, CRISPR-Cas systems provide adaptive immune responses against foreign genetic elements through RNA-guided nuclease activity. Recently, additional genes with non-nuclease functions have been found in genetic association with CRISPR syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01aa505b2f1f9d1597eb8a511370f079
https://doi.org/10.1126/science.add7450
https://doi.org/10.1126/science.add7450