Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jonathan Souquet"'
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe COVID-19 pandemic highlighted the urgent need for life-saving treatments, including vaccines, drugs, and therapeutic antibodies, delivered at unprecedented speed. During this period, recombinant antibody research and development cycle tim
Externí odkaz:
https://doaj.org/article/54b1178b4aac4290baf8422450257b3c
Autor:
Kevin Botelho Ferreira, Asma Benlegrimet, Gabriel Diane, Victor Pasquier, Raphael Guillot, Marc De Poli, Loïc Chappuis, Nandita Vishwanathan, Jonathan Souquet, Hervé Broly, Jean‐Marc Bielser
Publikováno v:
Biotechnology progressREFERENCES. 38(4)
Implementation of continuous in lieu of batch upstream processing (USP) and downstream process (DSP) for the production of recombinant therapeutic protein is a significant paradigm change. The present report describes how the first kilograms of monoc
Autor:
null Kevin Botelho Ferreira, null Asma Benlegrimet, null Gabriel Diane, null Victor Pasquier, null Raphael Guillot, null Marc De Poli, null Loïc Chappuis, null Nandita Vishwanathan, null Jonathan Souquet, null Hervé Broly, null Jean‐Marc Bielser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daa0c07a3f13087f41a6378c290c01d1
https://doi.org/10.1002/btpr.3259/v2/response1
https://doi.org/10.1002/btpr.3259/v2/response1
Autor:
Caterina Ruggeri, Hervé Broly, Moritz Wolf, Fabian Feidl, Massimo Morbidelli, Sebastian Vogg, Matevz Podobnik, Alessandro Butté, Nicole Ulmer, Ruben Wälchli, Jonathan Souquet
Publikováno v:
Biotechnology and Bioengineering. 117:1367-1380
Integrated continuous manufacturing is entering the biopharmaceutical industry. The main drivers range from improved economics, manufacturing flexibility, and more consistent product quality. However, studies on fully integrated production platforms
Autor:
James Angelo, Ruben Wälchli, Sebastian Vogg, Fabian Feidl, Zheng Jian Li, Jonathan Souquet, Sanchayita Ghose, Xavier Le Saoût, Hervé Broly, Mariana Ressurreição, Massimo Morbidelli, Xuankuo Xu
Publikováno v:
Biotechnology and Bioengineering, 117 (3)
Monoclonal antibodies (mAbs) and related recombinant proteins continue to gain importance in the treatment of a great variety of diseases. Despite significant advances, their manufacturing can still present challenges owing to their molecular complex
Publikováno v:
Biotechnology and Bioengineering. 116:1973-1985
The development of mammalian cell perfusion cultures is still laborious and complex to perform due to the limited availability of scale-down models and limited knowledge of time- and cost-effective procedures. The maximum achievable viable cell densi
Autor:
David Brühlmann, Jürgen Hemberger, Zeynep Manco, Alessandra D'Angelo, Eugenio Galano, Jonathan Souquet, Thomas Vuillemin, Abhijeet Satwekar, Markus Sauer, Angelo Palmese, Martin Jordan, Hervé Broly
Publikováno v:
Biotechnology and Bioengineering. 116:1017-1028
Glycosylation, a critical product quality attribute, may affect the efficacy and safety of therapeutic proteins in vivo. Chinese hamster ovary fed-batch cell culture batches yielded consistent glycoprofiles of a Fc-fusion antibody comprizing three di
Publikováno v:
Biotechnology Progress. 36
Media preparation for perfusion cell culture processes contributes significantly to operational costs and the footprint of continuous operations for therapeutic protein manufacturing. In this study, definitions are given for the use of a perfusion eq
Autor:
Massimo Morbidelli, Hervé Broly, Martin Jordan, Alessandro Butté, David Brühlmann, Matthieu Stettler, Raphael Ducommun, Philipp Zürcher, Michael Sokolov, Jonathan Souquet
Publikováno v:
Biotechnology Progress. 36
Multivariate latent variable methods have become a popular and versatile toolset to analyze bioprocess data in industry and academia. This work spans such applications from the evaluation of the role of the standard process variables and metabolites
Autor:
Martin Jordan, Michael Sokolov, Hervé Broly, Jonathan Souquet, Massimo Morbidelli, Philipp Zürcher, David Brühlmann, Alessandro Butté, Matthieu Stettler, Raphael Ducommun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb4b99a0c65274a88a9e3699efee044
https://doi.org/10.1002/btpr.3012/v2/response1
https://doi.org/10.1002/btpr.3012/v2/response1