Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jonathan Shintaku"'
Autor:
Jonathan Shintaku, Wolfgang M. Pernice, Wafaa Eyaid, Jeevan B. GC, Zuben P. Brown, Marti Juanola-Falgarona, Javier Torres-Torronteras, Ewen W. Sommerville, Debby M.E.I. Hellebrekers, Emma L. Blakely, Alan Donaldson, Ingrid van de Laar, Cheng-Shiun Leu, Ramon Marti, Joachim Frank, Kurenai Tanji, David A. Koolen, Richard J. Rodenburg, Patrick F. Chinnery, H.J.M. Smeets, Gráinne S. Gorman, Penelope E. Bonnen, Robert W. Taylor, Michio Hirano
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Mitochondrial DNA (mtDNA) depletion/deletions syndromes (MDDS) encompass a clinically and etiologically heterogenous group of mitochondrial disorders caused by impaired mtDNA maintenance. Among the most frequent causes of MDDS are defects in nucleosi
Externí odkaz:
https://doaj.org/article/c33cc000db5c486fac28f774f3298015
Autor:
Jennifer M. Peterson, David J. Wang, Vikram Shettigar, Steve R. Roof, Benjamin D. Canan, Nadine Bakkar, Jonathan Shintaku, Jin-Mo Gu, Sean C. Little, Nivedita M. Ratnam, Priya Londhe, Leina Lu, Christopher E. Gaw, Jennifer M. Petrosino, Sandya Liyanarachchi, Huating Wang, Paul M. L. Janssen, Jonathan P. Davis, Mark T. Ziolo, Sudarshana M. Sharma, Denis C. Guttridge
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function throug
Externí odkaz:
https://doaj.org/article/aa724b3e4c7b4ada9b67a708841b1195
Autor:
Jonathan Shintaku, Jennifer M. Peterson, Erin E. Talbert, Jin-Mo Gu, Katherine J. Ladner, Dustin R. Williams, Kambiz Mousavi, Ruoning Wang, Vittorio Sartorelli, Denis C. Guttridge
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 514-526 (2016)
MyoD is a key regulator of skeletal myogenesis that directs contractile protein synthesis, but whether this transcription factor also regulates skeletal muscle metabolism has not been explored. In a genome-wide ChIP-seq analysis of skeletal muscle ce
Externí odkaz:
https://doaj.org/article/4a436be3d23f49989082e1f87fce1083
Autor:
Denis C. Guttridge, Katherine J. Ladner, Kambiz Mousavi, Ruoning Wang, Jonathan Shintaku, Jin-Mo Gu, Erin E. Talbert, Jennifer M. Peterson, Dustin R. Williams, Vittorio Sartorelli
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 514-526 (2016)
SummaryMyoD is a key regulator of skeletal myogenesis that directs contractile protein synthesis, but whether this transcription factor also regulates skeletal muscle metabolism has not been explored. In a genome-wide ChIP-seq analysis of skeletal mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c5470abe65915a72af2ffb0a2a1121
http://www.sciencedirect.com/science/article/pii/S2211124716312153
http://www.sciencedirect.com/science/article/pii/S2211124716312153
Autor:
Huating Wang, Jin Mo Gu, Jennifer M. Peterson, Sandya Liyanarachchi, Christopher E. Gaw, Vikram Shettigar, Mark T. Ziolo, Benjamin D. Canan, Jennifer M. Petrosino, Steve R. Roof, Sudarshana M. Sharma, Denis C. Guttridge, Nadine Bakkar, David J. Wang, Leina Lu, Paul M.L. Janssen, Jonathan P. Davis, Sean C. Little, Priya Londhe, Jonathan Shintaku, Nivedita M. Ratnam
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Duchenne muscular dystrophy (DMD) is a neuromuscular disorder causing progressive muscle degeneration. Although cardiomyopathy is a leading mortality cause in DMD patients, the mechanisms underlying heart failure are not well understood. Previously,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63bf87ccb4cd7d383c6c439c75e5c0f
https://doi.org/10.1038/s41467-018-05910-1
https://doi.org/10.1038/s41467-018-05910-1
Autor:
Jonathan, Shintaku, Denis C, Guttridge
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1460
Mitochondrial function is a key component of skeletal muscle health, and its dysfunction has been associated with a wide variety of diseases. Microplate-based respirometry measures aerobic respiration of live cells through extracellular changes in ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9d99132e784a64f98f6eccbd611d85c
https://pubmed.ncbi.nlm.nih.gov/27492183
https://pubmed.ncbi.nlm.nih.gov/27492183
Autor:
Denis C. Guttridge, Jonathan Shintaku
Publikováno v:
Methods in Molecular Biology ISBN: 9781493938087
Mitochondrial function is a key component of skeletal muscle health, and its dysfunction has been associated with a wide variety of diseases. Microplate-based respirometry measures aerobic respiration of live cells through extracellular changes in ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13ec0a6a0ae7ef699854e279d15fd5e0
https://doi.org/10.1007/978-1-4939-3810-0_23
https://doi.org/10.1007/978-1-4939-3810-0_23
Autor:
Jonathan Shintaku, Yoko Mullen, Jeffrey Rawson, Chih Pin Liu, Shin Itakura, Taihei Ito, Fouad Kandeel, Ivan Todorov, Sadaki Asari, Indu Nair
Publikováno v:
Pancreas. 40:846-854
OBJECTIVES Allogeneic mesenchymal stem cells (MSCs) and bone marrow cells (BMCs) were cotransplanted in nonobese diabetic mice after none myeloablative preconditioning and the development of chimerism, insulitis, diabetes, and graft-versus-host disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c6e551d161dc33275aee0efa343671f
https://doi.org/10.1097/mpa.0b013e318215cdce
https://doi.org/10.1097/mpa.0b013e318215cdce
Autor:
Denis C. Guttridge, Jonathan Shintaku
Publikováno v:
Current opinion in clinical nutrition and metabolic care. 16(3)
Purpose of review Nuclear factor-kappaB (NF-κB) activation is associated with a wide range of muscle-related diseases. Here, we review the evidence implicating specific NF-κB components in different disease pathologies and discuss therapies designe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c75a3c565a8ae949992ff4d3f799083
https://pubmed.ncbi.nlm.nih.gov/23493016
https://pubmed.ncbi.nlm.nih.gov/23493016
Autor:
Indu Nair, Ivan Todorov, Taihei Ito, Kevin Ferreri, Jeffrey Rawson, Fouad Kandeel, Jonathan Shintaku, Shin Itakura, Sadaki Asari, Yoko Mullen
Publikováno v:
Transplantation. 89(12)
BACKGROUND Bone marrow-derived mesenchymal stem cells (MSCs) are known to produce vascular endothelial growth factor. We hypothesize that co-transplantation of MSCs and islets promotes revascularization and improves islet graft function. METHODS Lewi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768455f8ae8c21618a37bbc2cfe7c7c3
https://pubmed.ncbi.nlm.nih.gov/20568673
https://pubmed.ncbi.nlm.nih.gov/20568673