Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Jonathan Schug"'
Autor:
Richard A. Stone, John W. Tobias, Wenjie Wei, Jonathan Schug, Xia Wang, Lixin Zhang, P. Michael Iuvone, Debora L. Nickla
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The prevalence of myopia (nearsightedness) is increasing to alarming levels, but its etiology remains poorly understood. Because both laboratory and clinical findings suggest an etiologic role for circadian rhythms in myopia development, we
Externí odkaz:
https://doaj.org/article/632b8575791f42609d74fd17ad24de8b
Autor:
Jinping Liu, Lan Cheng, Hilana El‐Mekkoussi, Charles‐Antoine Assenmacher, Michelle Y. Y. Lee, Danielle R. Jaffe, Kaisha Garvin‐Darby, Ashleigh Morgan, Elisabetta Manduchi, Jonathan Schug, Klaus H. Kaestner
Publikováno v:
Cancer Communications, Vol 43, Iss 6, Pp 706-710 (2023)
Externí odkaz:
https://doaj.org/article/5963c665bcf24e208a07aef245825a7a
Autor:
Darrell Eacret, Elisabetta Manduchi, Julia Noreck, Emma Tyner, Polina Fenik, Amelia D. Dunn, Jonathan Schug, Sigrid C. Veasey, Julie A. Blendy
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Disrupted sleep is a symptom of many psychiatric disorders, including substance use disorders. Most drugs of abuse, including opioids, disrupt sleep. However, the extent and consequence of opioid-induced sleep disturbance, especially during
Externí odkaz:
https://doaj.org/article/46e6f3cd581c4b7d935a19695d273593
Autor:
Nicholas F. Lahens, Thomas G. Brooks, Dimitra Sarantopoulou, Soumyashant Nayak, Cris Lawrence, Antonijo Mrčela, Anand Srinivasan, Jonathan Schug, John B. Hogenesch, Yoseph Barash, Gregory R. Grant
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background The accurate interpretation of RNA-Seq data presents a moving target as scientists continue to introduce new experimental techniques and analysis algorithms. Simulated datasets are an invaluable tool to accurately assess the perfo
Externí odkaz:
https://doaj.org/article/e652ef326a1f48d3a154408788505a58
Autor:
Robert Warneford-Thomson, Parisha P Shah, Patrick Lundgren, Jonathan Lerner, Jason Morgan, Antonio Davila, Benjamin S Abella, Kenneth Zaret, Jonathan Schug, Rajan Jain, Christoph A Thaiss, Roberto Bonasio
Publikováno v:
eLife, Vol 11 (2022)
The COVID-19 pandemic has created an urgent need for rapid, effective, and low-cost SARS-CoV-2 diagnostic testing. Here, we describe COV-ID, an approach that combines RT-LAMP with deep sequencing to detect SARS-CoV-2 in unprocessed human saliva with
Externí odkaz:
https://doaj.org/article/9b49fdfccfcf407fb781dcfbe7bcac38
Autor:
Iliya Lefterov, Cody M. Wolfe, Nicholas F. Fitz, Kyong Nyon Nam, Florent Letronne, Richard J. Biedrzycki, Julia Kofler, Xianlin Han, Jianing Wang, Jonathan Schug, Radosveta Koldamova
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-16 (2019)
Abstract Background The application of advanced sequencing technologies and improved mass-spectrometry platforms revealed significant changes in gene expression and lipids in Alzheimer’s disease (AD) brain. The results so far have prompted further
Externí odkaz:
https://doaj.org/article/ec23950c70644aa5888106a51ae0e5fd
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
Autor:
Martin G. Scherm, Isabelle Serr, Adam M. Zahm, Jonathan Schug, Saverio Bellusci, Rossella Manfredini, Victoria K. Salb, Katharina Gerlach, Benno Weigmann, Anette-Gabriele Ziegler, Klaus H. Kaestner, Carolin Daniel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.
Externí odkaz:
https://doaj.org/article/224be2193f454379b9efe6527272f625
Autor:
Minghui Wu, Michelle Y.Y. Lee, Varun Bahl, Daniel Traum, Jonathan Schug, Irina Kusmartseva, Mark A. Atkinson, Guanjie Fan, Klaus H. Kaestner
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109919- (2021)
Summary: Type 2 diabetes mellitus (T2D) is a chronic age-related disorder characterized by hyperglycemia due to the failure of pancreatic beta cells to compensate for increased insulin demand. Despite decades of research, the pathogenic mechanisms un
Externí odkaz:
https://doaj.org/article/a8c0452dd1184df08e2878403748613b
Autor:
Daniel Traum, Yue J. Wang, Kathleen B. Schwarz, Jonathan Schug, David K.H. Wong, Harry L.A. Janssen, Norah A. Terrault, Mandana Khalili, Abdus S. Wahed, Karen F. Murray, Phillip Rosenthal, Simon C. Ling, Norberto Rodriguez-Baez, Richard K. Sterling, Daryl T.Y. Lau, Timothy M. Block, Michael D. Feldman, Elizabeth E. Furth, William M. Lee, David E. Kleiner, Anna S. Lok, Klaus H. Kaestner, Kyong-Mi Chang
Publikováno v:
JCI Insight, Vol 6, Iss 7 (2021)
Studies of human hepatitis B virus (HBV) immune pathogenesis are hampered by limited access to liver tissues and technologies for detailed analyses. Here, utilizing imaging mass cytometry (IMC) to simultaneously detect 30 immune, viral, and structura
Externí odkaz:
https://doaj.org/article/93b831a5139543daa027542543de4d77
Autor:
Dana Avrahami, Yue J. Wang, Jonathan Schug, Eseye Feleke, Long Gao, Chengyang Liu, Ali Naji, Benjamin Glaser, Klaus H. Kaestner
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101057- (2020)
Objective: Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes (T2D). However, the prevalence, plasticity and functional consequences of this cellular state remain unknown. Methods: We employed single-cell RNAseq to
Externí odkaz:
https://doaj.org/article/e60539f3d94f4165bd1ce11d43216d9a