Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jonathan S. Rosenblum"'
Autor:
Eric S Okerberg, Anna Hainley, Heidi Brown, Arwin Aban, Senait Alemayehu, Ann Shih, Jane Wu, Matthew P Patricelli, John W Kozarich, Tyzoon Nomanbhoy, Jonathan S Rosenblum
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172649 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0152934.].
Externí odkaz:
https://doaj.org/article/a8fee0abbac8433b9e3e6fd4953734b3
Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics.
Autor:
Eric S Okerberg, Anna Hainley, Heidi Brown, Arwin Aban, Senait Alemayehu, Ann Shih, Jane Wu, Matthew P Patricelli, John W Kozarich, Tyzoon Nomanbhoy, Jonathan S Rosenblum
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152934 (2016)
We describe the identification of a novel, tumor-specific missense mutation in the active site of casein kinase 1α (CSNK1A1) using activity-based proteomics. Matched normal and tumor colon samples were analyzed using an ATP acyl phosphate probe in a
Externí odkaz:
https://doaj.org/article/ffc6200c89354154984d306f8d950e36
Autor:
Toshiyuki Matsui, Motomichi Fujita, Yuji Ishibashi, Tyzoon Nomanbhoy, Jonathan S Rosenblum, Michiaki Nagasawa
Publikováno v:
Open Forum Infectious Diseases
Background Rhinovirus (RV) is a major respiratory virus that poses a threat to immunocompromised people and those with underlying disease. However, there are no approved therapies. Moreover, RV infection cannot be prevented by a vaccine because there
Autor:
Susana R Chaves, Jonathan S Rosenblum
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16846 (2011)
The Karyopherin (Kap) family of nuclear transport receptors enables trafficking of proteins to and from the nucleus in a precise, regulated manner. Individual members function in overlapping pathways, while simultaneously being very specific for thei
Externí odkaz:
https://doaj.org/article/8dd435265217489fb20e50dd790f72ba
Autor:
Senait Alemayehu, Jonathan S. Rosenblum, Geeta Sharma, Tyzoon K. Nomanbhoy, Arwin Aban, Maria Sykes, John W. Kozarich, Subha Vogeti, Jiangyue Wu, Heidi E. Brown
Publikováno v:
Biochemistry. 55:5434-5441
Palbociclib is a cyclin-dependent kinase (CDK) 4/CDK6 inhibitor approved for breast cancer that is estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative. We profiled palbociclib in cells either sensitive or resi
Autor:
Gregory N. Cosma, William E. Achanzar, Jiangyue Wu, Lauro Minimo, Carolyn F. Moyer, Mark S. Kirby, Mark D. Gorrell, Nicole D. Ordway, Laura Rosini-Marthaler, Russell Gullo, Kristina D. Chadwick, Eric. B. Harstad, Jonathan S. Rosenblum
Publikováno v:
Regulatory Peptides. 186:26-35
Dipeptidyl peptidases (DPPs) are proteolytic enzymes that regulate many physiological systems by degrading signaling peptides. DPP8 and DPP9 are distinct from DPP4 in sequence, cellular localization and expression levels, thus implying distinct funct
Autor:
Helge Weissig, Shyama Sidique, John W. Kozarich, Emme C.K. Lin, Tyzoon K. Nomanbhoy, Jonathan S. Rosenblum, Junichi Ishiyama, Yi Hu, Bei Li, Christopher M. Amantea
Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain. Genetic deletion of ERK5 is embryonic lethal, and tissue-restricted dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa0e539b27866c3e1d8419d25b4f8e3
https://europepmc.org/articles/PMC5081620/
https://europepmc.org/articles/PMC5081620/
Autor:
Helge Weissig, Bei Li, Junichi Ishiyama, Yi Hu, Shyama Sidique, Tyzoon K. Nomanbhoy, Jonathan S. Rosenblum, Emme C.K. Lin, Christopher A. Amantea, John W. Kozarich
Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain. Genetic deletion of ERK5 is embryonic lethal and tissue-restricted delet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb49cdb1aa5edb36cb53312a114b6d1f
https://doi.org/10.1101/038513
https://doi.org/10.1101/038513
Autor:
Lutz Nährlich, Andreas Guenther, Markus O. Henke, Bruce K. Rubin, Christian Müller, Jonathan S. Rosenblum, Shashi Chillappagari, Poornima Mahavadi
Publikováno v:
J. Cyst. Fibros. 15, 325-331 (2016)
Background Neutrophil elastase (NE) rapidly degrades gel-forming airway mucins in cystic fibrosis (CF) sputum. We hypothesized that KRP-109, a small molecule NE inhibitor, would inhibit CF mucin degradation in vitro . Methods Sputa were collected fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a25ea9d07314feef047915754bd5de
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=47188
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=47188
Autor:
Kevin R. Shreder, Tyzoon K. Nomanbhoy, Ayako Nakamura, Anna Katrin Szardenings, Shigeki Seto, Jonathan S. Rosenblum, Brandon Leen, Oana Cociorva, Kai Nakamura, Bei Li, Marek Liyanage, John W. Kozarich, Qiang Li, Yasushi Kohno, Kazuhiro Yumoto, Kyoko Okada, Masahiro Nomura, Melissa C. Zhang, Arwin Aban
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5948-5951
The synthesis, GSK-3β inhibitory activity, and anti-microbial activity of bicyclic and tricyclic derivatives of the 5,7-diamino-6-fluoro-4-quinolone-3-carboxylic acid scaffold were studied. Kinase selectivity profiling indicated that members of this