Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jonathan S. Packer"'
Autor:
Lauren M Saunders, Abhishek K Mishra, Andrew J Aman, Victor M Lewis, Matthew B Toomey, Jonathan S Packer, Xiaojie Qiu, Jose L McFaline-Figueroa, Joseph C Corbo, Cole Trapnell, David M Parichy
Publikováno v:
eLife, Vol 8 (2019)
Thyroid hormone (TH) regulates diverse developmental events and can drive disparate cellular outcomes. In zebrafish, TH has opposite effects on neural crest derived pigment cells of the adult stripe pattern, limiting melanophore population expansion,
Externí odkaz:
https://doaj.org/article/d802aca4e8474f9799616ec7022d2e47
Autor:
Lena Christiansen, Lauren M. Saunders, Vijay Ramani, Dana Jackson, Hannah A. Pliner, Jay Shendure, Cole Trapnell, Frank J. Steemers, Jonathan S. Packer, José L. McFaline-Figueroa, Fan Zhang, Riza M. Daza, Sanjay Srivatsan, Junyue Cao
Publikováno v:
Science
Single-cell chemical transcriptomics Single-cell transcriptomic technologies have emerged as powerful tools to explore cellular heterogeneity at the resolution of individual cells. Srivatsan et al. now add another layer of information and complexity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf2683662eb6b8785c1a44f5749bf05
https://doi.org/10.1126/science.aax6234
https://doi.org/10.1126/science.aax6234
Autor:
Jonathan S. Packer, Parker Grosjean, Mary C. Regier, Carlos Lois, Kelly R. Stevens, Paul D. Lampe, Sanjay Srivatsan, Jennifer M. Franks, Jon Ladd, Cole Trapnell, Malte Spielmann, Jay Shendure, Sarah Saxton, Madeleine Duran, Eliza Barkan
Publikováno v:
Science (New York, N.Y.). 373(6550)
Localizing gene expression Single-cell RNA sequencing can provide information about cellular relationships based on shared transcriptomes, but most methods lose spatial information. Those methods that do retain spatial information can be limited to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31ee2e041b98d9ff84e779a19b05894
https://pubmed.ncbi.nlm.nih.gov/34750575
https://pubmed.ncbi.nlm.nih.gov/34750575
Autor:
Cole Trapnell, Jonathan S. Packer
Publikováno v:
Trends in Genetics. 34:653-665
Cells in a multicellular organism fulfill specific functions by enacting cell type specific programs of gene regulation. Single cell RNA sequencing technologies have provided a transformative view of cell type specific gene expression, the output of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148e9e66d03ceb9e47a736b0cd59eaaa
https://doi.org/10.1016/j.tig.2018.06.001
https://doi.org/10.1016/j.tig.2018.06.001
Autor:
Kenneth A. Matreyek, Andrew J. Hill, Cole Trapnell, Jonathan S. Packer, Molly Gasperini, Lea M. Starita, Jay Shendure, José L. McFaline-Figueroa, Dana Jackson
Publikováno v:
Nature methods
Several groups recently coupled CRISPR perturbations and single-cell RNA-seq for pooled genetic screens. We demonstrate that vector designs of these studies are susceptible to ∼50% swapping of guide RNA-barcode associations because of lentiviral te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af21cb20fd0dd370378db3cab1f3487f
https://doi.org/10.1038/nmeth.4604
https://doi.org/10.1038/nmeth.4604
Publikováno v:
Nature methods
Single-cell gene expression studies promise to unveil rare cell types and cryptic states in development and disease through a stunningly high-resolution view of gene regulation. However, measurements from single-cell RNA-Seq are highly variable, frus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfe5a45c076fcde32155e83276ad34c
https://doi.org/10.1038/nmeth.4150
https://doi.org/10.1038/nmeth.4150
Autor:
Junhyong Kim, Derek Stefanik, Cole Trapnell, John I. Murray, Jonathan S. Packer, Qin Zhu, Elicia Preston, Hannah Dueck, Priya Sivaramakrishnan, Chau Huynh, Robert H. Waterston, Kai Tan
Publikováno v:
Science. 365
Identifying terminal nematode cells Single-cell RNA sequencing provides the power to identify the developmental trajectory of an organism. However, identifying the temporal lineage of cell development can be difficult without large-scale analyses. Pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6c83b5def97ab80d2795df0c1ddb9e0
https://doi.org/10.1126/science.aax1971
https://doi.org/10.1126/science.aax1971
Autor:
Lauren M. Saunders, Cole Trapnell, Matthew B. Toomey, David M. Parichy, Victor M Lewis, Joseph C. Corbo, Andy Aman, Xiaojie Qiu, Abhishek Kumar Mishra, Jonathan S. Packer, José L. McFaline-Figueroa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb8101b611c83a5130988b883761fcec
https://doi.org/10.7554/elife.45181.040
https://doi.org/10.7554/elife.45181.040
Autor:
Jonathan S, Packer, Qin, Zhu, Chau, Huynh, Priya, Sivaramakrishnan, Elicia, Preston, Hannah, Dueck, Derek, Stefanik, Kai, Tan, Cole, Trapnell, Junhyong, Kim, Robert H, Waterston, John I, Murray
Publikováno v:
Science (New York, N.Y.). 365(6459)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3dfff10de8825430be1da01ecb85ffce
https://pubmed.ncbi.nlm.nih.gov/31548660
https://pubmed.ncbi.nlm.nih.gov/31548660
Autor:
Cole Trapnell, Jonathan S. Packer, Junhyong Kim, Robert H. Waterston, John I. Murray, Chau Huynh, Priya Sivaramakrishnan, Kai Tan, Hannah Dueck, Elicia Preston, Qin Zhu, Derek Stefanik
C. elegans is an animal with few cells, but a striking diversity of cell types. Here, we characterize the molecular basis for their specification by profiling the transcriptomes of 84,625 single embryonic cells. We identify 284 terminal and pre-termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc634d506cdd013febb27f674898037
https://doi.org/10.1101/565549
https://doi.org/10.1101/565549