Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Jonathan S. Oakhill"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
STK11 (serine-threonine kinase 11), also known as LKB1 (liver kinase B1) is a highly conserved master kinase that regulates cellular metabolism and polarity through a complex signaling network involving AMPK and 12 other AMPK-related kinases. Germlin
Externí odkaz:
https://doaj.org/article/2d9eb9223df44d2c99aa1717a5575061
Autor:
Marina Katerelos, Kurt Gleich, Geoff Harley, Kim Loh, Jonathan S. Oakhill, Bruce E. Kemp, David P. de Souza, Vinod K. Narayana, Melinda T. Coughlan, Adrienne Laskowski, Naomi X.Y. Ling, Lisa Murray-Segal, Robert Brink, Mardiana Lee, David A. Power, Peter F. Mount
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116730- (2024)
Acute kidney injury (AKI) disrupts energy metabolism. Targeting metabolism through AMP-activated protein kinase (AMPK) may alleviate AKI. ATX-304, a pan-AMPK activator, was evaluated in C57Bl/6 mice and tubular epithelial cell (TEC) cultures. Mice re
Externí odkaz:
https://doaj.org/article/49bb1d8ce07747f89e0a801918a28713
Autor:
Heena Doshi, Katrin Spengler, Amod Godbole, Yi Sing Gee, Jonathan Baell, Jonathan S. Oakhill, Andreas Henke, Regine Heller
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Herpes simplex virus type 1 (HSV-1) is a widespread contagious pathogen, mostly causing mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon reactivation of the virus in immunocompromised patients, may
Externí odkaz:
https://doaj.org/article/9cbb143a3735452499080643bf1bfa2d
Autor:
Florentina Negoita, Alex B. Addinsall, Kristina Hellberg, Conchita Fraguas Bringas, Paul S. Hafen, Tyler J. Sermersheim, Marianne Agerholm, Christopher T.A. Lewis, Danial Ahwazi, Naomi X.Y. Ling, Jeppe K. Larsen, Atul S. Deshmukh, Mohammad A. Hossain, Jonathan S. Oakhill, Julien Ochala, Jeffrey J. Brault, Uma Sankar, David H. Drewry, John W. Scott, Carol A. Witczak, Kei Sakamoto
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101761- (2023)
Objective: The AMP-activated protein kinase (AMPK) gets activated in response to energetic stress such as contractions and plays a vital role in regulating various metabolic processes such as insulin-independent glucose uptake in skeletal muscle. The
Externí odkaz:
https://doaj.org/article/9d5e5d0c7c7842288457d872e1ccedfc
Autor:
Ayeshah A. Rosdah, Belinda M. Abbott, Christopher G. Langendorf, Yali Deng, Jia Q. Truong, Helen M. M. Waddell, Naomi X. Y. Ling, William J. Smiles, Lea M. D. Delbridge, Guei-Sheung Liu, Jonathan S. Oakhill, Shiang Y. Lim, Jessica K. Holien
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous pathophysiological processes. Despite being the most widely used Drp1 inhibitor, the spec
Externí odkaz:
https://doaj.org/article/81d43f7ed5984ba3b02b0644c4d9b73f
Autor:
Kaitlin R. Morrison, Tingting Wang, Kuan Yoow Chan, Eleanor W. Trotter, Ari Gillespie, Michael Z. Michael, Jonathan S. Oakhill, Iain M. Hagan, Janni Petersen
Publikováno v:
Open Biology, Vol 13, Iss 4 (2023)
Expression and activity of the AMP-activated protein kinase (AMPK) α1 catalytic subunit of the heterotrimeric kinase significantly correlates with poor outcome for colorectal cancer patients. Hence there is considerable interest in uncovering signal
Externí odkaz:
https://doaj.org/article/8f517fb0f4714e258cf9dc1d821f5c08
Autor:
Chieh-Hsin Yang, Danise Ann-Onda, Xuzhu Lin, Stacey Fynch, Shaktypreya Nadarajah, Evan G. Pappas, Xin Liu, John W. Scott, Jonathan S. Oakhill, Sandra Galic, Yanchuan Shi, Alba Moreno-Asso, Cassandra Smith, Thomas Loudovaris, Itamar Levinger, Decio L. Eizirik, D. Ross Laybutt, Herbert Herzog, Helen E. Thomas, Kim Loh
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101413- (2022)
Objectives: Loss of functional β-cell mass is a key factor contributing to poor glycemic control in advanced type 2 diabetes (T2D). We have previously reported that the inhibition of the neuropeptide Y1 receptor improves the islet transplantation ou
Externí odkaz:
https://doaj.org/article/02909523106a409cb9dc517663f1220c
Autor:
Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael M. Couñago, Brittany Stork, Christopher G. Langendorf, Kevin Nay, Jonathan S. Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R. Means, Brian York, Donald P. McDonnell, John W. Scott, Daniel E. Frigo, David H. Drewry
Publikováno v:
Cells, Vol 12, Iss 2, p 287 (2023)
The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a se
Externí odkaz:
https://doaj.org/article/22978372a9134263a1f17e8fa4cfa4d9
Autor:
Philipp Rhein, Eric M. Desjardins, Ping Rong, Danial Ahwazi, Nicolas Bonhoure, Jens Stolte, Matthieu D. Santos, Ashley J. Ovens, Amy M. Ehrlich, José L. Sanchez Garcia, Qian Ouyang, Julian M. Yabut, Mads Kjolby, Mathieu Membrez, Niels Jessen, Jonathan S. Oakhill, Jonas T. Treebak, Pascal Maire, John W. Scott, Matthew J. Sanders, Patrick Descombes, Shuai Chen, Gregory R. Steinberg, Kei Sakamoto
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101228- (2021)
Objective: The metabolic master-switch AMP-activated protein kinase (AMPK) mediates insulin-independent glucose uptake in muscle and regulates the metabolic activity of brown and beige adipose tissue (BAT). The regulatory AMPKγ3 isoform is uniquely
Externí odkaz:
https://doaj.org/article/c0481e7493a4441682f49290f3acce6a
Autor:
Christina Vrahnas, Martha Blank, Toby A. Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwin, Huynh Nguyen, Mark R. Forwood, Yifang Hu, Mika Ikegame, Keith R. Bambery, Cyril Petibois, Eleanor J. Mackie, Mark J. Tobin, Gordon K. Smyth, Jonathan S. Oakhill, T. John Martin, Natalie A. Sims
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Osteoblasts mediate bone formation, and their differentiation requires expression of EphrinB2. Here, the authors show that EphrinB2 is also expressed by osteocytes, and that its genetic ablation in mice is associated with altered autophagy, elevated
Externí odkaz:
https://doaj.org/article/2738dceae2514fd1ae0b6fb54d703a48