Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Jonathan S. Marchant"'
Autor:
Jonathan S. Marchant
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/a5461156146340a28eb531465c4d8841
Publikováno v:
Frontiers in Parasitology, Vol 3 (2024)
Infections caused by parasitic flatworms impart a significant disease burden. This is well exemplified by the neglected tropical disease schistosomiasis, which afflicts millions of people worldwide. The anti-schistosomal activity of various chemotype
Externí odkaz:
https://doaj.org/article/369c7c4f9bc2430483c741df42342ef2
Autor:
Yu Yuan, Vikas Arige, Ryo Saito, Qianru Mu, Gabriela C. Brailoiu, Gustavo J.S. Pereira, Stephen R. Bolsover, Marco Keller, Franz Bracher, Christian Grimm, Eugen Brailoiu, Jonathan S. Marchant, David I. Yule, Sandip Patel
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113628- (2024)
Summary: Lysosomes and the endoplasmic reticulum (ER) are Ca2+ stores mobilized by the second messengers NAADP and IP3, respectively. Here, we establish Ca2+ signals between the two sources as fundamental building blocks that couple local release to
Externí odkaz:
https://doaj.org/article/0c93f40a9db1428081d0c197d6e1ae0a
Publikováno v:
Frontiers in Parasitology, Vol 2 (2023)
IntroductionPraziquantel (PZQ), an anthelmintic drug discovered in the 1970s, is still used to treat schistosomiasis and various other infections caused by parasitic flatworms. PZQ causes a triad of phenotypic effects on schistosome worms – rapid d
Externí odkaz:
https://doaj.org/article/f570ee5d68e140f382206ef0edd325b1
Autor:
Obinna C. Ubah, Eric W. Lake, Gihan S. Gunaratne, Joseph P. Gallant, Marie Fernie, Austin J. Robertson, Jonathan S. Marchant, Tyler D. Bold, Ryan A. Langlois, William E. Matchett, Joshua M. Thiede, Ke Shi, Lulu Yin, Nicholas H. Moeller, Surajit Banerjee, Laura Ferguson, Marina Kovaleva, Andrew J. Porter, Hideki Aihara, Aaron M. LeBeau, Caroline J. Barelle
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Shark antibodies (Variable New Antigen Receptors, VNARs) are the smallest naturally occurring antibody fragments. Here, the authors screen a VNAR phage display library against the SARS-CoV2 receptor binding domain (RBD) and identify VNARs that neutra
Externí odkaz:
https://doaj.org/article/d533a0ef137944a582f18b4def8a849b
Autor:
Gihan S. Gunaratne, Robyn T. Rebbeck, Lindsey M. McGurran, Yasheng Yan, Thiago Arzua, Talia Frolkis, Daniel J. Sprague, Xiaowen Bai, Razvan L. Cornea, Timothy F. Walseth, Jonathan S. Marchant
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103706- (2022)
Summary: Ryanodine receptors (RyRs) are large, intracellular ion channels that control Ca2+ release from the sarco/endoplasmic reticulum. Dysregulation of RyRs in skeletal muscle, heart, and brain has been implicated in various muscle pathologies, ar
Externí odkaz:
https://doaj.org/article/94f636ca50da4ffaa3d30ac7bc2841a5
Autor:
Evgeny G. Chulkov, Emery Smith, Claudia M. Rohr, Nawal A. Yahya, Sang-Kyu Park, Louis Scampavia, Timothy P. Spicer, Jonathan S. Marchant
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
Given the worldwide burden of neglected tropical diseases, there is ongoing need to develop novel anthelmintic agents to strengthen the pipeline of drugs to combat these burdensome infections. Many diseases caused by parasitic flatworms are treated u
Externí odkaz:
https://doaj.org/article/79a1cd713faf4c3d89313b9826e1c45d
Autor:
Malika Arhatte, Gihan S. Gunaratne, Charbel El Boustany, Ivana Y. Kuo, Céline Moro, Fabrice Duprat, Magali Plaisant, Hélène Duval, Dahui Li, Nicolas Picard, Anais Couvreux, Christophe Duranton, Isabelle Rubera, Sophie Pagnotta, Sandra Lacas-Gervais, Barbara E. Ehrlich, Jonathan S. Marchant, Aaron M. Savage, Fredericus J. M. van Eeden, Robert N. Wilkinson, Sophie Demolombe, Eric Honoré, Amanda Patel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Polycystin-2 (PC2) is an ion channel commonly found mutated in autosomal dominant polycystic kidney disease. Here Arhatte et al. identify transmembrane protein 33 (TMEM33) as a regulator of PC2 function at the endoplasmic reticulum, and find that del
Externí odkaz:
https://doaj.org/article/a10e8cca0f764891af20836abbb4891c
Autor:
Sandip Patel, Yu Yuan, Cheng-Chang Chen, Dawid Jaślan, Gihan Gunaratne, Christian Grimm, Taufiq Rahman, Jonathan S. Marchant
Publikováno v:
Cells, Vol 11, Iss 15, p 2368 (2022)
Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically relevant proteins that reside on endolysosomal vesicles. Here, we review the electrophysiology of these channels. Direct macroscopic recordings of recombinant TPCs expres
Externí odkaz:
https://doaj.org/article/49fbe1279a6943b6b400febdf218443d
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 550-558 (2018)
Serotonin (5-HT) is an important regulator of numerous aspects of flatworm biology, ranging from neuromuscular function to sexual maturation and egg laying. In the parasitic blood fluke Schistosoma mansoni, 5-HT targets several G-protein coupled rece
Externí odkaz:
https://doaj.org/article/db71d1a8f8ec4ac395e71f56acf5cce8