Zobrazeno 1 - 10 of 186 pro vyhledávání: '"Jonathan S. Katz"'
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Akademický článek
A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS
Autor: Jonathan S. Katz, Jeffrey D. Rothstein, Merit E. Cudkowicz, Angela Genge, Björn Oskarsson, Avis B. Hains, Chen Chen, Joshua Galanter, Braydon L. Burgess, William Cho, Geoffrey A. Kerchner, Felix L. Yeh, Arundhati Sengupta Ghosh, Sravanthi Cheeti, Logan Brooks, Lee Honigberg, Jessica A. Couch, Michael E. Rothenberg, Flavia Brunstein, Khema R. Sharma, Leonard van denBerg, James D. Berry, Jonathan D. Glass
Publikováno v: Annals of Clinical and Translational Neurology, Vol 9, Iss 1, Pp 50-66 (2022)
Abstract Objective Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (AL
Externí odkaz: https://doaj.org/article/fe4980573fc74660b0489437b3effc6d
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3
Slowing the loss of physical function in amyotrophic lateral sclerosis with edaravone: Post hoc analysis of ALSFRS‐R item scores in pivotal study MCI186 ‐19
Autor: Koji Takei, Erik P Pioro, Fumihiro Takahashi, Stephen Apple, Benjamin Rix Brooks, Jeffrey Zhang, Jonathan S. Katz
Publikováno v: Muscle & Nerve. 65:180-186
Introduction Phase 3 study MCI186-19 demonstrated less loss of physical function with edaravone versus placebo, as measured by the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) total score. A 1-point drop in an individual A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc03e13f12153605f2d0c575f963c75
https://doi.org/10.1002/mus.27467
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4
Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial
Autor: Michael Pulley, Mikko Kuoppamäki, Carolyn A Young, Jesus S. Mora Pardina, Kumaraswamy Sivakumar, Toni Sarapohja, Michael A. Elliott, Chafic Karam, Sandeep Rana, Orla Hardiman, Nathan P. Staff, Letizia Mazzini, Gabriele Mora, Thomas F. Meyer, Colleen O'Connell, Stéphanie Delstanche, Elham Bayat, Michael D. Weiss, Waqar Waheed, Nenad Mitrovic, Philippe Corcia, Marie-Hélène Soriani, Edward J. Kasarskis, Claudia Caponnetto, Dale J. Lange, Tuan Vu, Leo McCluskey, Berthold Schrank, Angela Genge, Matthew C. Kiernan, Valtteri V Aho, Manu Jokela, Philip Van Damme, Juan F. Vázquez Costa, Maurizio Inghilleri, Wolfgang Löscher, David Schultz, Tero Tapiola, Susanne Petri, Adriano Chiò, Gary L. Pattee, Julian Großkreutz, Ammar Al-Chalabi, Aziz Shaibani, Susan Mathers, Kevin J. Felice, Kimberly Goslin, James Caress, Matthias Boentert, Albert C. Ludolph, Aleksandar Radunovic, Robert D. Henderson, James Wymer, Todd Levine, Jakob Rath, Merrilee Needham, William Camu, Gaurav Guliani, Rune Johansson, Leonard H. van den Berg, Namita Goyal, Mark B. Bromberg, Bjorn Oskarsson, Annie Dionne, Eduardo Locatelli, Brent T. Harris, Suma Babu, Richard Bedlack, John Ravits, Jinsy A. Andrews, Philippe Couratier, Gabriele Siciliano, Hannu Laaksovirta, Kourosh Rezania, Lawrence Korngut, Eduardo Aguera Morales, Peter M Andersen, Eva Farrero Munoz, David Lacomis, Stephen N. Scelsa, Chris Garratt, Matthew Burford, Merit Cudkowicz, Nicholas J. Maragakis, Wendy Johnston, Martin M. Brown, Johannes Prudlo, Justin Y. Kwan, Dominic B. Fee, Senda Ajroud-Driss, Stephen A. Goutman, John Turnbull, Michael H. Rivner, Timothy M. Miller, Jan De Bleecker, Caroline Ingre, Luis Varona, Genevieve Matte, Daragh Heitzman, Robert Untucht, Lorne Zinman, Adam Quick, Jonathan S. Katz
Publikováno v: The Lancet Neurology. 20:821-831
Summary Background There is an urgent unmet need for new therapies in amyotrophic lateral sclerosis. In a clinical study with healthy volunteers, levosimendan, a calcium sensitiser, was shown to improve neuromechanical efficiency and contractile func
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e159b8bed1a737713c1c2f5bf0a571
https://doi.org/10.1016/s1474-4422(21)00242-8
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Long‐term survival of participants in the CENTAUR trial of sodium phenylbutyrate‐taurursodiol in amyotrophic lateral sclerosis
Autor: Meghan Hall, Janet P. Wittes, Gary L. Pattee, Eric A. Macklin, Eric Tustison, Tuan Vu, Zi-Fan Yu, Samuel P. Dickson, Rudolph E. Tanzi, Liberty Jenkins, Suma Babu, Michael A. Elliott, Jonathan S. Katz, Chafic Karam, Patricia L. Andres, Terry Heiman-Patterson, Stephen N. Scelsa, Christina Fournier, Joseph Ostrow, Timothy M. Miller, Joshua N Cohen, Daragh Heitzman, Edward J. Kasarskis, Derek Dagostino, Patrick D. Yeramian, Colin Quinn, Rebecca Randall, Lindsay Pothier, James Wymer, Hong Yu, Gale Kittle, Newman Knowlton, Michelle McGovern, Shafeeq Ladha, Jason Walker, Jeffrey D. Rothstein, Adam Quick, James Chan, Kent L. Leslie, Prasha Vigneswaran, Maria E. St. Pierre, Kristin M. Johnson, Walter Gilbert, Namita Goyal, James B. Caress, Marianne Chase, Sabrina Paganoni, Jonathan D. Glass, Justin Klee, Merit Cudkowicz, Jeremy M. Shefner, Suzanne Hendrix, Carlayne E. Jackson, Margaret Owegi, James D. Berry, David A. Schoenfeld, Alexander Sherman, Stephen A. Goutman, Matthew Eydinov, Andrea Swenson, Samuel Maiser
Publikováno v: Muscle & Nerve
An orally administered, fixed‐dose coformulation of sodium phenylbutyrate‐taurursodiol (PB‐TURSO) significantly slowed functional decline in a randomized, placebo‐controlled, phase 2 trial in ALS (CENTAUR). Herein we report results of a long
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c577e9ab26d1e9b80fcf0903d01570f
https://doi.org/10.1002/mus.27091
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Harnessing the power of the electronic health record for ALS research and quality improvement: CReATe CAPTURE-ALS and the ALS Toolkit
Autor: Sumaira Hussain, Jonathan S. Katz, James Caress, David Walk, Nancy Smider, Tom Yosick, Carlayne E. Jackson, Jessica Hernandez, Anne-Laure Grignon, Michael Benatar, Volkan Granit, Joanne Wuu
Publikováno v: Muscle Nerve
The electronic health record (EHR) is designed principally to support the provision and documentation of clinical care, as well as billing and insurance claims. Broad implementation of the EHR, however, also yields an opportunity to use EHR data for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c167aedebd3e232eba7ae9147ab16ec
https://pubmed.ncbi.nlm.nih.gov/34730240
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Bilateral Ptosis and Limb Myokymia: Regional Variant of Guillain-Barré Syndrome?
Autor: Gil I. Wolfe, Felix Cheng, Richard J. Barohn, Jonathan S. Katz
Publikováno v: RRNMF Neuromuscular Journal. 1:22-24
Isolated bilateral ptosis as an initial sign of Guillain-Barré Syndrome (GBS) with subsequent limb paralysis or paresis has been reported. However, to our knowledge, bilateral ptosis with subsequent limb myokymia but without ophthalmoplegia, facial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c58d6763257fca3d9eea39ef7ffc0236
https://doi.org/10.17161/rrnmf.v1i2.13579
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Current practice patterns in CIDP: A cross-sectional survey of neurologists in the United States
Autor: John D. England, Paul A. Nisbet, Jonathan S. Katz, Deborah F. Gelinas
Publikováno v: Journal of the Neurological Sciences. 397:84-91
To evaluate how neurologists make decisions regarding chronic inflammatory demyelinating polyneuropathy (CIDP), we conducted a cross-sectional quantitative survey of 100 community neurologists in the United States. Only 13% cited using the European F
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa8d282b1f102907715361d6df413dd
https://doi.org/10.1016/j.jns.2018.11.031
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10
Akademický článek
Cognitive and Behavioral Impairment in Amyotrophic Lateral Sclerosis
Autor: Woolley, Susan C., Jonathan S. Katz
Publikováno v: In Physical Medicine & Rehabilitation Clinics of North America 2008 19(3):607-617
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