Výsledky vyhledávání - "Jonathan S. Foot"

Combining monoamine oxidase B and semicarbazide-sensitive amine oxidase enzyme inhibition to address inflammatory disease

Autor: Jonathan S, Foot, Alberto, Buson, Mandar, Deodhar, Alison D, Findlay, Alan D, Robertson, Craig I, Turner, Tin, Yow, Wenbin, Zhou, Wolfgang, Jarolimek

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 74:128942

The discovery of a dual MAO-B/SSAO inhibitor PXS-5131 is reported. The compound offers a compact and rigid three-dimensional structure with superior selectivity over MAO-A. Potency and selectivity are linked to both the double bond geometry and stere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4c64f7cbe0681ee40033a81278070c
https://doi.org/10.1016/j.bmcl.2022.128942

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Inhibition of semicarbazide‐sensitive amine oxidase/vascular adhesion protein‐1 reduces lipopolysaccharide‐induced neuroinflammation

Autor: Bernard W. Balleine, Serena Becchi, Jonathan S. Foot, Wolfgang Jarolimek, Alberto Buson

Publikováno v: British Journal of Pharmacology. 174:2302-2317

Background and Purpose Neuroinflammation is initiated by a variety of stimuli including infections, sepsis, neurodegenerative diseases or traumatic brain injury and, if not adequately controlled, can lead to various degrees of neuronal damage and beh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a20eb1b3c8a24b30b8d8b19634b1454
https://doi.org/10.1111/bph.13832

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Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer

Autor: Thomas R. Cox, Paul Timpson, Lidia E. Leonte, Lukram Babloo Singh, Wolfgang Jarolimek, Joan Chang, Janine T. Erler, Morghan C. Lucas, Jonathan S. Foot, Mandar Deodhar, Marc Garcia-Montolio, Alison D. Findlay

Publikováno v: Chang, J, Lucas, M C, Leonte, L E, Garcia-Montolio, M, Singh, L B, Findlay, A D, Deodhar, M, Foot, J S, Jarolimek, W, Timpson, P, Erler, J T & Cox, T R 2017, ' Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer ', Oncotarget . https://doi.org/10.18632/oncotarget.15257
Chang, J, Lucas, M C, Leonte, L E, Garcia-Montolio, M, Singh, L B, Findlay, A D, Deodhar, M, Foot, J S, Jarolimek, W, Timpson, P, Erler, J T & Cox, T R 2017, ' Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer ', OncoTarget, vol. 8, no. 16, pp. 26066-26078 . https://doi.org/10.18632/oncotarget.15257
Oncotarget

// Joan Chang 1 , Morghan C. Lucas 2 , Lidia E. Leonte 1 , Marc Garcia-Montolio 1 , Lukram Babloo Singh 1 , Alison D. Findlay 3 , Mandar Deodhar 3 , Jonathan S. Foot 3 , Wolfgang Jarolimek 3 , Paul Timpson 2 , Janine T. Erler 1 , Thomas R. Cox 1, 2 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d1ecaaf3616c775c04eb52cde9a905
https://doi.org/10.18632/oncotarget.15257

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The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model

Autor: Ama-Tawiah Essilfie, Philip M. Hansbro, Andrew G. Jarnicki, Wolfgang Jarolimek, Wheeldon K, Jonathan S. Foot, Heidi Schilter, Gang Liu, Yow Tt

Publikováno v: British Journal of Pharmacology. 173:3161-3175

Background and Purpose Chronic obstructive pulmonary disease (COPD) is a major cause of illness and death, often induced by cigarette smoking (CS). It is characterized by pulmonary inflammation and fibrosis that impairs lung function. Existing treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::442d19e4a77681e64fd9d714ecc43240
https://doi.org/10.1111/bph.13573

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Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration

Autor: Jonathan S. Foot, Heidi Schilter, Wolfgang Jarolimek, Lívia D. Tavares, Joerg Mattes, Angélica T. Vieira, Remo Castro Russo, Adam Collison, Tin T Yow, Mauro M. Teixeira

Publikováno v: Respiratory Research

© Schilter et al. Background and purpose: The persistent influx of neutrophils into the lung and subsequent tissue damage are characteristics of COPD, cystic fibrosis and acute lung inflammation. VAP-1/SSAO is an endothelial bound adhesion molecule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f70b6623e9dace961a21716c1d97ab8
https://doi.org/10.1186/s12931-015-0200-z

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The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1)

Autor: Andrew Holt, Jonathan S. Foot, Craig Ivan Turner, Aldo Olivieri, Ian A. McDonald, Diego Silva, Ellen M. van Dam, Mandar Deodhar, Ping Yin

Publikováno v: Bioorganicmedicinal chemistry letters. 22(12)

A new class of 3-fluoroallyl amine-based SSAO/VAP-1 inhibitors is reported. These compounds have excellent selectivity over diamine oxidase, MAO-A and MAO-B. Synthesis and SAR studies leading to compound 28 (PXS-4159A) are reported. The pharmacokinet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70da8507dc54027204a56780fa27cf5c
https://pubmed.ncbi.nlm.nih.gov/22595173

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ChemInform Abstract: Protein-Protein Coupling and Its Application to Functional Red Cell Substitutes

Autor: Ronald Kluger, Jonathan S. Foot, Adelle A. Vandersteen

Publikováno v: ChemInform. 41

The need for an alternative to red cells for oxygen transport in transfusions has led to the creation of hemoglobin-based oxygen carriers, materials produced by chemical modification or genetic engineering of human or bovine hemoglobin. Modifications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1ff9958e4ca72c7ba81ad8619a60de2
https://doi.org/10.1002/chin.201024266

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