Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jonathan S. Fletcher"'
Publikováno v:
Neuro-oncology Advances
Plexiform neurofibromas (PNF) are peripheral nerve tumors caused by bi-allelic loss of NF1 in the Schwann cell (SC) lineage. PNF are common in individuals with Neurofibromatosis type I (NF1) and can cause significant patient morbidity, spurring resea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e25d46bdd0a4a3741b5a1a38415d7d2
https://doi.org/10.1093/noajnl/vdz045
https://doi.org/10.1093/noajnl/vdz045
Autor:
Michael T. Borchers, William J. Zacharias, Seth D. Reighard, Matthew T. Weirauch, Hitesh Deshmukh, Stephen N. Waggoner, Leah C. Kottyan, Kelly M. Rangel, Jonathan S. Fletcher, Ivayla E. Gyurova, Sanjeeth Rajaram, Laura M. Canaday, Durga Krishnamurthy, Andrew Cox, David E. Ochayon, Ayad Ali
Publikováno v:
Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12843c76ecf87589b93796056ec628e5
http://europepmc.org/articles/PMC7219410
http://europepmc.org/articles/PMC7219410
Autor:
Nancy Ratner, Edwin Jousma, Mitchell G. Springer, Jianqiang Wu, Jonathan S. Fletcher, Tilat A. Rizvi, Mi-Ok Kim, Kwangmin Choi, Eva Dombi
Publikováno v:
Oncogene
Plexiform neurofibroma, a benign peripheral nerve tumor, is associated with the biallelic loss of function of the NF1 tumor suppressor in Schwann cells. Here, we show that FLLL32, a small molecule inhibitor of JAK2/STAT3 signaling, reduces neurofibro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c9b74b41a8f9cd8f2928f157350348
https://doi.org/10.1038/s41388-018-0600-x
https://doi.org/10.1038/s41388-018-0600-x
Publikováno v:
Science Signaling. 12
Neurofibromatosis type 2 is an inherited, neoplastic disease associated with schwannomas, meningiomas, and ependymomas and that is caused by inactivation of the tumor suppressor gene NF2.immortalized mouse The NF2 gene product, Merlin, has no intrins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ca2ea866101bde462c25ba5953b1ef
https://doi.org/10.1126/scisignal.aau8749
https://doi.org/10.1126/scisignal.aau8749
Autor:
Walter J. Jessen, Eva Dombi, Tilat A. Rizvi, Nathan Salomonis, Kashish Chetal, Mi-Ok Kim, Jianqiang Wu, Nancy Ratner, Jay Pundavela, Jonathan S. Fletcher
Publikováno v:
Cancer Immunology Research. 8:B32-B32
Plexiform neurofibroma is a major contributor to morbidity in neurofibromatosis type I (NF1) patients. Macrophages and mast cells infiltrate neurofibroma, and data from mouse models implicate these leukocytes in neurofibroma development. Anti-inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::008a668ca2490ad747b169efeabe787d
https://doi.org/10.1158/2326-6074.tumimm18-b32
https://doi.org/10.1158/2326-6074.tumimm18-b32
Autor:
Kakajan Komurov, Jianqiang Wu, Nancy Ratner, Edwin Jousma, Kwangmin Choi, Jonathan S. Fletcher, Jose A. Cancelas
Publikováno v:
Scientific Reports
Neurofibromas are benign peripheral nerve tumors driven by NF1 loss in Schwann cells (SCs). Macrophages are abundant in neurofibromas, and macrophage targeted interventions may have therapeutic potential in these tumors. We generated gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6559d8965fc48196317c8c5910ae3a4
https://doi.org/10.1038/srep43315
https://doi.org/10.1038/srep43315
Autor:
Jianqiang Wu, Kakajan Komurov, Nancy Ratner, Jose A. Cancelas, Edwin Jousma, Kwangmin Choi, Jonathan S. Fletcher
Publikováno v:
Cancer Immunology Research. 5:A04-A04
Neurofibromas are benign peripheral nerve tumors driven by NF1 loss in Schwann cells (SCs). Current evidence suggests that an inflammatory environment is critical for neurofibroma development and growth, however the roles of intercellular interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d11b409301d4827fd791388539578cca
https://doi.org/10.1158/2326-6074.tumimm16-a04
https://doi.org/10.1158/2326-6074.tumimm16-a04
The analysis of the spatial patterning of mRNA expression is critically important for assigning functional and physiological significance to a given gene product. Given the tens of thousands of mRNAs in the mammalian genome, a full assessment of indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5adb27daa8fa526d870eb58de3ae39
https://europepmc.org/articles/PMC2987549/
https://europepmc.org/articles/PMC2987549/
