Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Jonathan S Gootenberg"'
Autor:
Bernhard Schermer, Francesca Fabretti, Maximilian Damagnez, Veronica Di Cristanziano, Eva Heger, Sita Arjune, Nathan A Tanner, Thomas Imhof, Manuel Koch, Alim Ladha, Julia Joung, Jonathan S Gootenberg, Omar O Abudayyeh, Volker Burst, Feng Zhang, Florian Klein, Thomas Benzing, Roman-Ulrich Müller
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0238612 (2020)
BackgroundRapid and extensive testing of large parts of the population and specific subgroups is crucial for proper management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and decision-making in times of a pandemic outbr
Externí odkaz:
https://doaj.org/article/d5e7d69119164d80be6a22fed0519fa1
Autor:
Cameron Myhrvold, Michael Baym, Nikita Hanikel, Luvena L Ong, Jonathan S Gootenberg, Peng Yin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Techniques for structural characterization and quantification of DNA origami are still poorly developed, despite advances in other aspects of DNA nanotechnology. Here, the authors combine barcoding and next generation sequencing to simultaneously ima
Externí odkaz:
https://doaj.org/article/572c0cfcad854ef0ae527750838866f5
Autor:
Jonathan Strecker, F. Esra Demircioglu, David Li, Guilhem Faure, Max E. Wilkinson, Jonathan S. Gootenberg, Omar O. Abudayyeh, Hiroshi Nishimasu, Rhiannon K. Macrae, Feng Zhang
Publikováno v:
Science
In prokaryotes, CRISPR-Cas systems provide adaptive immune responses against foreign genetic elements through RNA-guided nuclease activity. Recently, additional genes with non-nuclease functions have been found in genetic association with CRISPR syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01aa505b2f1f9d1597eb8a511370f079
https://doi.org/10.1126/science.add7450
https://doi.org/10.1126/science.add7450
Autor:
Kazuki Kato, Sae Okazaki, Cian Schmitt-Ulms, Kaiyi Jiang, Wenyuan Zhou, Junichiro Ishikawa, Yukari Isayama, Shungo Adachi, Tomohiro Nishizawa, Kira S. Makarova, Eugene V. Koonin, Omar O. Abudayyeh, Jonathan S. Gootenberg, Hiroshi Nishimasu
Publikováno v:
Science. 378:882-889
The type III-E CRISPR–Cas7-11 effector binds a CRISPR RNA (crRNA) and the putative protease Csx29 and catalyzes crRNA-guided RNA cleavage. We report cryo–electron microscopy structures of the Cas7-11–crRNA–Csx29 complex with and without targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e793aff81b0997fbfa107ccf00927c26
https://doi.org/10.1126/science.add7347
https://doi.org/10.1126/science.add7347
Autor:
Matthew T. N. Yarnall, Eleonora I. Ioannidi, Cian Schmitt-Ulms, Rohan N. Krajeski, Justin Lim, Lukas Villiger, Wenyuan Zhou, Kaiyi Jiang, Sofya K. Garushyants, Nathaniel Roberts, Liyang Zhang, Christopher A. Vakulskas, John A. Walker, Anastasia P. Kadina, Adrianna E. Zepeda, Kevin Holden, Hong Ma, Jun Xie, Guangping Gao, Lander Foquet, Greg Bial, Sara K. Donnelly, Yoshinari Miyata, Daniel R. Radiloff, Jordana M. Henderson, Andrew Ujita, Omar O. Abudayyeh, Jonathan S. Gootenberg
Publikováno v:
Nat Biotechnol
Programmable genome integration of large, diverse DNA cargo without DNA repair of exposed DNA double-strand breaks remains an unsolved challenge in genome editing. We present programmable addition via site-specific targeting elements (PASTE), which u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f0141730000285cf08335780ce35c5
https://doi.org/10.1038/s41587-022-01527-4
https://doi.org/10.1038/s41587-022-01527-4
Autor:
Kaiyi Jiang, Jeremy Koob, Xi Dawn Chen, Rohan N. Krajeski, Yifan Zhang, Verena Volf, Wenyuan Zhou, Samantha R. Sgrizzi, Lukas Villiger, Jonathan S. Gootenberg, Fei Chen, Omar O. Abudayyeh
Publikováno v:
Nature Biotechnology. 41:698-707
Programmable approaches to sense and respond to the presence of specific RNAs in biological systems have broad applications in research, diagnostics, and therapeutics. Here we engineer a programmable RNA-sensing technology, reprogrammable ADAR sensor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15c23e6c5f7cf1e01a75b83ff614c03
https://doi.org/10.1038/s41587-022-01534-5
https://doi.org/10.1038/s41587-022-01534-5
Publikováno v:
Crispr. :99-120
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a27a5fccbc581d171343c13ec2b5be97
https://doi.org/10.1002/9781683673798.ch7
https://doi.org/10.1002/9781683673798.ch7
Autor:
Ian M. Slaymaker, Pablo Mesa, Max J. Kellner, Soumya Kannan, Edward Brignole, Jeremy Koob, Patricia R. Feliciano, Stefano Stella, Omar O. Abudayyeh, Jonathan S. Gootenberg, Jonathan Strecker, Guillermo Montoya, Feng Zhang
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3741-3751.e5 (2019)
Summary: Type VI CRISPR-Cas systems contain programmable single-effector RNA-guided RNases, including Cas13b, one of the four known family members. Cas13b, which has been used for both RNA editing and nucleic acid detection, is unique among type VI C
Externí odkaz:
https://doaj.org/article/bf9da071e1ca429bb1c6fd1d45795839
Publikováno v:
Biochemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c40d623141e0e04198269fcc9532c4e1
https://doi.org/10.1021/acs.biochem.3c00159
https://doi.org/10.1021/acs.biochem.3c00159
Autor:
Omar O. Abudayyeh, Jonathan S. Gootenberg, Rohan N. Krajeski, Eugene V. Koonin, Eleonora I. Ioannidi, Ahsen Özcan, Brennan Peter Lee, Kira S. Makarova, Apolonia Gardner
Publikováno v:
Nature. 597:720-725
CRISPR–Cas interference is mediated by Cas effector nucleases that are either components of multisubunit complexes—in class 1 CRISPR–Cas systems—or domains of a single protein—in class 2 systems1–3. Here we show that the subtype III-E eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::423472c86f9f39638ace065a8cfe492c
https://doi.org/10.1038/s41586-021-03886-5
https://doi.org/10.1038/s41586-021-03886-5