Mobilization of cholesterol induces the transition from quiescence to growth in Caenorhabditis elegans through steroid hormone and mTOR signaling

Autor: Kathrin Schmeisser, Damla Kaptan, Bharath Kumar Raghuraman, Andrej Shevchenko, Jonathan Rodenfels, Sider Penkov, Teymuras V. Kurzchalia

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)

Abstract Recovery from the quiescent developmental stage called dauer is an essential process in C. elegans and provides an excellent model to understand how metabolic transitions contribute to developmental plasticity. Here we show that cholesterol

Externí odkaz: https://doaj.org/article/35fae9f82d1044519ad33c481e53f287

Physical bioenergetics

Autor: Matthias Heinemann, Denis V. Titov, Jonathon Howard, Shashi Thutupalli, Guillaume Le Treut, Jin Wang, Daniel J. Needleman, Pierre Ronceray, Kristi L. Montooth, Iman Tavassoly, Greg Huber, Xingbo Yang, Srividya Iyer-Biswas, Peter J. Foster, Jonathan Rodenfels, Michael Lynch, Simone Pigolotti, Sadasivan Shankar

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 26
Proceedings of the National Academy of Sciences of the United States of America, 118(26):e2026786118. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (26), pp.e2026786118. ⟨10.1073/pnas.2026786118⟩
Proc Natl Acad Sci U S A

International audience; Cells are the basic units of all living matter which harness the flow of energy to drive the processes of life. While the biochemical networks involved in energy transduction are well-characterized, the energetic costs and con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36372ad20b71cbd270ca6f20f6eed3e6
https://research.rug.nl/en/publications/02776b8c-1b63-43dd-a756-0041d1fefb25

Calorimetric Heat Dissipation Measurements of Developing Zebrafish Embryos

Autor: Karla M. Neugebauer, Jonathan Rodenfels

Publikováno v: Methods in Molecular Biology ISBN: 9781071615379

Living cells, tissues and organisms are open, metabolically active systems that constantly exchange matter and energy with their environment in the form of heat. The heat exchanged is equal to the net enthalpy of all chemical reactions taking place w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ebdb64e08c8c5e3bb2193746ba7c582
https://doi.org/10.1007/978-1-0716-1538-6_22

Contribution of increasing plasma membrane to the energetic cost of early zebrafish embryogenesis

Autor: Kartikeya Nagendra, Karla M. Neugebauer, Pablo Sartori, Jonathan Rodenfels, Jonathon Howard, Stefan Golfier

Publikováno v: Molecular Biology of the Cell

How do early embryos allocate the resources stored in the sperm and egg? Recently, we established isothermal calorimetry to measure heat dissipation by living zebra-fish embryos and to estimate the energetics of specific developmental events. During

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1dd4db14fff453cc22827806b66fa4
https://pubmed.ncbi.nlm.nih.gov/32049586

Heat Oscillations Driven by the Embryonic Cell Cycle Reveal the Energetic Costs of Signaling

Autor: Jonathan Rodenfels, Jonathon Howard, Karla M. Neugebauer

Publikováno v: Dev Cell

All living systems function out of equilibrium and exchange energy in the form of heat with their environment. Thus, heat flow can inform on the energetic costs of cellular processes, which are largely unknown. Here, we have repurposed an isothermal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b1bbd3eb5eed3724389c325c8cc921
https://doi.org/10.1016/j.devcel.2018.12.024