Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Jonathan R. Silva"'
Autor:
Guohui Zhang, Xianjin Xu, Zhiguang Jia, Yanyan Geng, Hongwu Liang, Jingyi Shi, Martina Marras, Carlota Abella, Karl L. Magleby, Jonathan R. Silva, Jianhan Chen, Xiaoqin Zou, Jianmin Cui
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Ca2+ activated BK channels are important for neural and muscle function. Here authors use a compound, BC5, to show that the interface between the cytosolic and voltage sensing domains is a major allosteric pathway for Ca2+ binding to open the channel
Externí odkaz:
https://doaj.org/article/67b10c912c5146eda08534fccfe9cc8f
Autor:
David Bloom, MD, Jamie N. Colombo, DO, Nathan Miller, BSN, Michael K. Southworth, MS, Christopher Andrews, PhD, Alexander Henry, MS, William B. Orr, MD, Jonathan R. Silva, PhD, Jennifer N. Avari Silva, MD, FHRS
Publikováno v:
Cardiovascular Digital Health Journal, Vol 3, Iss 5, Pp 232-240 (2022)
Background: Use of ultrasound (US) to facilitate vascular access has increased compared to landmark-based procedures despite ergonomic challenges and need for extrapolation of 2-dimensional images to understand needle position. The MantUS™ system (
Externí odkaz:
https://doaj.org/article/33459fbaae3a40daadbb44e4d579927c
Autor:
Christopher M. Andrews, Alexander B. Henry, Ignacio M. Soriano, Michael K. Southworth, Jonathan R. Silva
Publikováno v:
IEEE Journal of Translational Engineering in Health and Medicine, Vol 9, Pp 1-14 (2021)
Many clinical procedures would benefit from direct and intuitive real-time visualization of anatomy, surgical plans, or other information crucial to the procedure. Three-dimensional augmented reality (3D-AR) is an emerging technology that has the pot
Externí odkaz:
https://doaj.org/article/87d4cdbbe91c4b7b999706f98508ad7d
Autor:
Michael K. Southworth, Jennifer N. Avari Silva, Walter M. Blume, George F. Van Hare, Aarti S. Dalal, Jonathan R. Silva
Publikováno v:
IEEE Journal of Translational Engineering in Health and Medicine, Vol 8, Pp 1-10 (2020)
Cardiac electrophysiology procedures present the physician with a wealth of 3D information, typically presented on fixed 2D monitors. New developments in wearable mixed reality displays offer the potential to simplify and enhance 3D visualization whi
Externí odkaz:
https://doaj.org/article/1d16994b48b84c2e86064346ca3d369a
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The voltage-gated Na+ channel regulates the initiation and propagation of the action potential in excitable cells. The major cardiac isoform NaV1.5, encoded by SCN5A, comprises a monomer with four homologous repeats (I-IV) that each contain a voltage
Externí odkaz:
https://doaj.org/article/9f32dc39af854d98adabd1ec00e41505
Autor:
Wandi Zhu, Wei Wang, Paweorn Angsutararux, Rebecca L. Mellor, Lori L. Isom, Jeanne M. Nerbonne, Jonathan R. Silva
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Native myocardial voltage-gated sodium (NaV) channels function in macromolecular complexes comprising a pore-forming (α) subunit and multiple accessory proteins. Here, we investigated the impact of accessory NaVβ1 and NaVβ3 subunits on the functio
Externí odkaz:
https://doaj.org/article/3a1cd7dc535f4598ae819c3d1643d27f
Autor:
Jonathan D. Moreno, MD, PhD, Wandi Zhu, PhD, Kathryn Mangold, MS, Woenho Chung, BS, Jonathan R. Silva, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 736-751 (2019)
Summary: Antiarrhythmic treatment strategies remain suboptimal due to our inability to predict how drug interactions with ion channels will affect the ability of the tissues to initiate and sustain an arrhythmia. We built a multiscale molecular model
Externí odkaz:
https://doaj.org/article/eb3b4ebdc4e742ec9c4c12b82759495f
Publikováno v:
US Cardiology Review, Vol 16, Iss , Pp - (2022)
The use of innovative imaging practices in the field of interventional cardiology and electrophysiology has led to significant progress in both diagnostic and therapeutic capabilities. 3D reconstructions of 2D images allows a proceduralist to develop
Externí odkaz:
https://doaj.org/article/0553813b1e1a426f9fc5984e6fc37d15
Publikováno v:
eLife, Vol 11 (2022)
The resurgent component of the voltage-gated sodium current (INaR) is a depolarizing conductance, revealed on membrane hyperpolarizations following brief depolarizing voltage steps, which has been shown to contribute to regulating the firing properti
Externí odkaz:
https://doaj.org/article/2e8784b6ede74b6796c68e92f3bd9578
Autor:
Kasoorelope Oguntuyo, David Schuftan, Jingxuan Guo, Daniel Simmons, Druv Bhagavan, Jonathan D. Moreno, Po Wei Kang, Evan Miller, Jonathan R. Silva, Nathaniel Huebsch
Publikováno v:
Tissue Engineering Part C: Methods. 28:457-468
Drugs are often removed from clinical trials or market progression owing to their unforeseen effects on cardiac action potential and calcium handling. Induced pluripotent stem cell-derived cardiomyocytes and tissues fabricated from these cells are pr