Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jonathan R. McDearmid"'
Autor:
Jenna R. Sternberg, Andrew E. Prendergast, Lucie Brosse, Yasmine Cantaut-Belarif, Olivier Thouvenin, Adeline Orts-Del’Immagine, Laura Castillo, Lydia Djenoune, Shusaku Kurisu, Jonathan R. McDearmid, Pierre-Luc Bardet, Claude Boccara, Hitoshi Okamoto, Patrick Delmas, Claire Wyart
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Alteration of cerebrospinal fluid (CSF) flow and cilia defects are clinically associated with idiopathic scoliosis. This study shows that transient receptor potential channel Pkd2l1 is required for mechanosensory function of neurons detecting CSF flo
Externí odkaz:
https://doaj.org/article/88d9999b54c84d7280f863923497f69e
Autor:
Neal Rimmer, Ceinwen A. Tilley, Héctor Carreño Gutiérrez, Joseph Pinion, Florian Reichmann, Amir Al Oustah, Matthew J. Winter, Andrew M. J. Young, William H. J. Norton, Elisa Dalla Vecchia, Jonathan R. McDearmid
Publikováno v:
Acta physiologica (Oxford, England)REFERENCES. 230(4)
Aim Aggression is a behavioural trait characterized by the intention to harm others for offensive or defensive purposes. Neurotransmitters such as serotonin and dopamine are important mediators of aggression. However, the physiological role of the hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741e9cb3b18551c65d0fc95f6e4e4d43
https://pubmed.ncbi.nlm.nih.gov/32969183
https://pubmed.ncbi.nlm.nih.gov/32969183
Autor:
Lucie Brosse, Lydia Djenoune, Yasmine Cantaut-Belarif, Adeline Orts-Del’Immagine, Jenna R. Sternberg, Claude Boccara, Pierre-Luc Bardet, Patrick Delmas, Hitoshi Okamoto, Shusaku Kurisu, Andrew Prendergast, Jonathan R. McDearmid, Laura Castillo, Claire Wyart, Olivier Thouvenin
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-06225-x⟩
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-06225-x⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-06225-x⟩
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-06225-x⟩
Flow of cerebrospinal fluid (CSF) may contribute to spine morphogenesis, as mutations affecting both cilia motility and CSF flow lead to scoliosis1. However, the mechanisms underlying detection of the CSF flow in the central canal of the spinal cord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8727babfd9d94dc798d9d0109a2990
https://hal-amu.archives-ouvertes.fr/hal-02346202
https://hal-amu.archives-ouvertes.fr/hal-02346202
Autor:
A. Emre Sayan, Eyad Issa, Hanaa Al-Mahmoodi, Andrew F. Irvine, Jonathan R. McDearmid, Ibtihal Al-Shamarti, Nabil Jaunbocus, Peter Greaves, Ashley R. Dennison, Zamzam Almutairi, Christopher P. Neal, K.R. Straatman, Qais Al-Ismaeel, Marina Kriajevska, Eugene Tulchinsky, Catherine Moreman
Publikováno v:
British Journal of Cancer
Background S100 proteins have been implicated in various aspects of cancer, including epithelial-mesenchymal transitions (EMT), invasion and metastasis, and also in inflammatory disorders. Here we examined the impact of individual members of this fam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9699b2c17f188ad2f1fce5a7f87664e
https://pubmed.ncbi.nlm.nih.gov/31123345
https://pubmed.ncbi.nlm.nih.gov/31123345
Autor:
Jonathan R. McDearmid, Michael Jay
Publikováno v:
Current Biology. 25:R1138-R1140
Since their discovery almost a century ago, the functions of the cerebrospinal-fluid-contacting neurons have remained elusive: a new study paves the way towards understanding how these unusual spinal cord neurons regulate motor activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32c9910edeae0e8752c3d024981f00c
https://doi.org/10.1016/j.cub.2015.10.034
https://doi.org/10.1016/j.cub.2015.10.034
Autor:
François Gros-Louis, Luc Dupuis, Hajer El Oussini, Sylvie Dirrig-Grosch, Patrick A. Dion, Jean-Philippe Loeffler, Jérôme Sinniger, Nicolas Dupré, Pierre Drapeau, Jonathan R. McDearmid, William Camu, Guy A. Rouleau, Edor Kabashi, Inge A. Mejier, Valérie Bercier, Paul N. Valdmanis, David Hollinger, Vincent Meininger, Frédérique René
Publikováno v:
Human Molecular Genetics; Vol 22
The mutations P56S and T46I in the gene encoding vesicle-associated membrane protein-associated protein B/C (VAPB) cause ALS8, a familial form of amyotrophic lateral sclerosis (ALS). Overexpression of mutant forms of VAPB leads to cytosolic aggregate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1420a217cbc1d712e9ec9238e3c5ae
Publikováno v:
Zebrafish
Fin clipping of live fish under anesthesia is widely used to collect samples for DNA extraction. An alternative, potentially less invasive, approach involves obtaining samples by swabbing the skin of nonanesthetized fish. However, this method has yet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3a614ee4c1c57b651d4327534b5467
https://pubmed.ncbi.nlm.nih.gov/27788059
https://pubmed.ncbi.nlm.nih.gov/27788059
Autor:
Tennore Ramesh, Alexander McGown, Huaxia Tong, Pamela J. Shaw, Christine E. Beattie, Niki Panagiotaki, Sufana Al Mashhadi, Jonathan R. McDearmid, Alison N. Lyon, Natasha Redhead
Publikováno v:
Annals of Neurology
Neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) are characterized by the presence of protein inclusions in the affected neurons. Emerging data indicate that protein misfolding may be of mechanistic importance in these disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e4a2523be9ea3b31e68716eb3bfa83
https://doi.org/10.1002/ana.23780
https://doi.org/10.1002/ana.23780
Autor:
Annie Reynolds, Zoha Kibar, Jonathan R. McDearmid, Pierre Drapeau, Valeria Capra, Stéphanie Lachance, Elisa Merello, Philippe Gros, Patrizia De Marco
Publikováno v:
Mechanisms of Development. 127(7-8):385-392
In humans, rare non-synonymous variants in the planar cell polarity gene VANGL1 are associated with neural tube defects (NTDs). These variants were hypothesized to be pathogenic based mainly on genetic studies in a large cohort of NTD patients. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab21e61092da0fb1eae721047fac6d4
Autor:
Annie Reynolds, Joanne Berghout, Irena Kirillova, John B. Wallingford, Pierre Drapeau, Jonathan R. McDearmid, Zoha Kibar, Elena Torban, Melissa Mathieu, Patrizia De Marco, Julie M. Hayes, Elisa Merello, Philippe Gros, Valeria Capra
Publikováno v:
New England Journal of Medicine. 356:1432-1437
Neural-tube defects such as anencephaly and spina bifida constitute a group of common congenital malformations caused by complex genetic and environmental factors. We have identified three mutations in the VANGL1 gene in patients with familial types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311d1078d8be1f53a7361457995917b5
https://doi.org/10.1056/nejmoa060651
https://doi.org/10.1056/nejmoa060651