Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jonathan R. Heyen"'
Autor:
Barbra J. Sasu, Javier Chaparro-Riggers, Thomas Van Blarcom, Tao Sai, Jonathan R. Heyen, Roman Galetto, Mathilde Dusseaux, Adit Ghosh, Zea Melton, Shanshan Lang, Dinali Wijewarnasuriya, Jonathan Villanueva, Hongxiu Ning, Yvonne S.L. Mak, Bryan Smith, Silvia K. Tacheva-Grigorova, Nguyen Tan, Surabhi Srinivasan, Siler H. Panowski
Supplementary Figure from Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cc395cc018d8b6bdfec74c65ff1896
https://doi.org/10.1158/0008-5472.22674159.v1
https://doi.org/10.1158/0008-5472.22674159.v1
Autor:
Barbra J. Sasu, Javier Chaparro-Riggers, Thomas Van Blarcom, Tao Sai, Jonathan R. Heyen, Roman Galetto, Mathilde Dusseaux, Adit Ghosh, Zea Melton, Shanshan Lang, Dinali Wijewarnasuriya, Jonathan Villanueva, Hongxiu Ning, Yvonne S.L. Mak, Bryan Smith, Silvia K. Tacheva-Grigorova, Nguyen Tan, Surabhi Srinivasan, Siler H. Panowski
Supplementary Table from Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1113ecbc9d213d4a81b1c660bd8f61c0
https://doi.org/10.1158/0008-5472.22674150.v1
https://doi.org/10.1158/0008-5472.22674150.v1
Autor:
Barbra J. Sasu, Javier Chaparro-Riggers, Thomas Van Blarcom, Tao Sai, Jonathan R. Heyen, Roman Galetto, Mathilde Dusseaux, Adit Ghosh, Zea Melton, Shanshan Lang, Dinali Wijewarnasuriya, Jonathan Villanueva, Hongxiu Ning, Yvonne S.L. Mak, Bryan Smith, Silvia K. Tacheva-Grigorova, Nguyen Tan, Surabhi Srinivasan, Siler H. Panowski
CD70 is highly expressed in renal cell carcinoma (RCC), with limited expression in normal tissue, making it an attractive CAR T target for an immunogenic solid tumor indication. Here we generated and characterized a panel of anti-CD70 single-chain fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844e319864e18dd6100f22f2faf43456
https://doi.org/10.1158/0008-5472.c.6514085
https://doi.org/10.1158/0008-5472.c.6514085
Autor:
Barbra J. Sasu, Javier Chaparro-Riggers, Thomas Van Blarcom, Tao Sai, Jonathan R. Heyen, Roman Galetto, Mathilde Dusseaux, Adit Ghosh, Zea Melton, Shanshan Lang, Dinali Wijewarnasuriya, Jonathan Villanueva, Hongxiu Ning, Yvonne S.L. Mak, Bryan Smith, Silvia K. Tacheva-Grigorova, Nguyen Tan, Surabhi Srinivasan, Siler H. Panowski
Supplementary Data from Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7c8f3089a179567a7db902f74dd58c
https://doi.org/10.1158/0008-5472.22432208
https://doi.org/10.1158/0008-5472.22432208
Autor:
Jonathan R. Heyen, Brandy Chavez, Sergei Timofeevski, Murali Gururajan, Keith A. Ching, Szu-Yu Tang, Eleanore Hendrickson, Rui Eugene Yuanjin, Shawn D. Doran, Stephanie T. Shi, Gina Chu, Christopher P. Dillon, Jennifer Kinong, Yu 'Jerry' Zhou, Jon Oyer, Andrew R. Nager, Vinayak Rayannavar, Rajarshi Bhadra, Johnni Gullo-Brown, Indrawan James Mcalpine
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundP21-activated kinase 4 (PAK4) is a serine/threonine protein kinase that is mostly expressed in tumor and stroma cells. PAK4 activates tumor WNT/β-catenin pathway and regulates cellular morphology, motility, EMT, cell proliferation and surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb992a17f4468fd8accc364f85e3ea0e
https://doaj.org/article/f1d6517467594e24b8981f644a3baeab
https://doaj.org/article/f1d6517467594e24b8981f644a3baeab
Autor:
Nadia Kurd, Jessica Stanfield, Shih-Hsun Chen, Jonathan R. Heyen, Pawel K. Dominik, Shahram Salek-Ardakani, Sheng Ding, Zea Melton, Thomas Van Blarcom, Ryan Llewellyn, Wenjing Yang, Javier Chaparro-Riggers, Carole Wang, Kevin Lindquist
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundT cell checkpoint immunotherapies have shown promising results in the clinic, but most patients remain non-responsive. CD47-signal regulatory protein alpha (SIRPα) myeloid checkpoint blockade has shown early clinical activity in hematologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ad6e74c1d3fb964fc96627ba44077b
https://jitc.bmj.com/content/9/10/e003464.full
https://jitc.bmj.com/content/9/10/e003464.full
Autor:
Siler H. Panowski, Surabhi Srinivasan, Nguyen Tan, Silvia K. Tacheva-Grigorova, Bryan Smith, Yvonne S.L. Mak, Hongxiu Ning, Jonathan Villanueva, Dinali Wijewarnasuriya, Shanshan Lang, Zea Melton, Adit Ghosh, Mathilde Dusseaux, Roman Galetto, Jonathan R. Heyen, Tao Sai, Thomas Van Blarcom, Javier Chaparro-Riggers, Barbra J. Sasu
Publikováno v:
Cancer research. 82(14)
CD70 is highly expressed in renal cell carcinoma (RCC), with limited expression in normal tissue, making it an attractive CAR T target for an immunogenic solid tumor indication. Here we generated and characterized a panel of anti-CD70 single-chain fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a583bdd4c30a06fbda49871878e6d29d
https://pubmed.ncbi.nlm.nih.gov/35844172
https://pubmed.ncbi.nlm.nih.gov/35844172
Autor:
Shih-Hsun Chen, Jonathan R. Heyen, Pawel K. Dominik, Nadia Kurd, Jessica Stanfield, Sheng Ding, Thomas Van Blarcom, Kevin Lindquist, Carole Wang, Zea Melton, Javier Chaparro-Riggers, Shahram Salek-Ardakani, Ryan Llewellyn, Wenjing Yang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundT cell checkpoint immunotherapies have shown promising results in the clinic, but most patients remain non-responsive. CD47-SIRPα myeloid checkpoint blockade has shown early clinical activity in hematologic malignancies. However, CD47 expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33320dec5a8d027c0b207e415f7e413d
https://doi.org/10.1136/jitc-2021-sitc2021.267
https://doi.org/10.1136/jitc-2021-sitc2021.267
Autor:
Janette Sutton, Yajin Ni, Mark W. Leonard, Barbra Sasu, Julien Valton, Dominic Justewicz, Cesar Sommer, Jonathan R. Heyen, Trevor Bentley, Julianne Smith, Thomas Van Blarcom
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 19:e24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf585a3ca4b91928c9d931a149aba59a
https://doi.org/10.1016/j.clml.2019.09.035
https://doi.org/10.1016/j.clml.2019.09.035
Autor:
Mathilde Dusseaux, Barbra Sasu, Roman Galetto, Thomas Van Blarcom, Surabhi Srinivasan, Siler Panowski, Nguyen Tan, Niranjana Aditi Nagarajan, Tao Sai, Jonathan R. Heyen, Silvia K. Tacheva-Grigorova
Publikováno v:
Cancer Research. 79:2326-2326
Renal Cell Carcinoma (RCC) represents a substantial patient population, with 65,340 new cases estimated in the US in 2018. Patients with localized tumors undergo nephrectomy, however 30-40% of patients develop metastasis, with a 5-year median surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e146e2af6032eaf19ca072a0b9c4a46e
https://doi.org/10.1158/1538-7445.am2019-2326
https://doi.org/10.1158/1538-7445.am2019-2326