Výsledky vyhledávání - "Jonathan R. Halstead"

Rac controls PIP5K localisation and PtdIns(4,5)P2 synthesis, which modulates vinculin localisation and neurite dynamics

Autor: Nicolai E. Savaskan, Willem-Jan Keune, Peter L. Hordijk, Francis van Horck, Iman van den Bout, Jean Paul ten Klooster, Amra Hajdo-Milasinovic, Mireille Snell, Nullin Divecha, Jonathan R. Halstead

Publikováno v: Journal of cell science, 123(20), 3535-3546. Company of Biologists Ltd
Halstead, J R, Savaskan, N E, Van Den Bout, I, Van Horck, F, Hajdo-Milasinovic, A, Snell, M, Keune, W J, Ten Klooster, J P, Hordijk, P L & Divecha, N 2010, ' Rac controls PIP5K localisation and PtdIns(4,5)P2 synthesis, which modulates vinculin localisation and neurite dynamics ', Journal of Cell Science, vol. 123, no. 20, pp. 3535-3546 . https://doi.org/10.1242/jcs.062679
Journal of Cell Science, 123(20), 3535-3546. Company of Biologists Ltd

In N1E-115 cells, neurite retraction induced by neurite remodelling factors such as lysophosphatidic acid, sphingosine 1-phosphate and semaphorin 3A require the activity of phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks). PIP5Ks synthesise the ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8050ab98d6103aa79278180c9554352
https://doi.org/10.1242/jcs.062679

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An emerging role for PtdIns(4,5)P2-mediated signalling in human disease

Autor: Kees Jalink, Jonathan R. Halstead, Nullin Divecha

Publikováno v: Trends in Pharmacological Sciences. 26:654-660

Although an established regulator of many cellular functions, the phosphoinositide phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5) P 2 ] appears to have evaded the attention of drug-discovery companies. An increasing number of reports have ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4651aa79c4a906776966a5a58ebffba6
https://doi.org/10.1016/j.tips.2005.10.004

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Type I PIPkinases Interact with and Are Regulated by the Retinoblastoma Susceptibility Gene Product—pRB

Autor: Alrik P. Los, Mieke Roefs, Nullin Divecha, Clive D'Santos, Jonathan R. Halstead, Andrew J. Bannister

Publikováno v: Current Biology. 12:582-587

Inositide signaling at the plasma membrane has been implicated in the regulation of numerous cellular processes including cytoskeletal dynamics, vesicle trafficking [1], and gene transcription [2]. Studies have also shown that a distinct inositide pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7ae7b8efde4b2c31b4c6abea0649c7
https://doi.org/10.1016/s0960-9822(02)00769-8

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Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells

Autor: Jonathan H. CLARKE, Andrew J. LETCHER, Clive S. D'SANTOS, Jonathan R. HALSTEAD, Robin F. IRVINE, Nullin DIVECHA

Publikováno v: Biochemical Journal. 357:905-910

Previous data suggest the existence of discrete pools of inositol lipids, which are components of a nuclear phosphoinositide (PI) cycle. However, it is not known whether the contents of these pools are regulated during cell proliferation. In the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ea42badc7d1e16a896296250926bf74
https://doi.org/10.1042/bj3570905

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Interaction of the Type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4,5-bisphosphate in the regulation of PLD2 activity

Autor: Mieke Roefs, Michael J.O. Wakelam, Nullin Divecha, Sabine d'Andrea, Kahlid M. Saqib, Mar Fernandez‐Borga, L. C. J. M. Oomen, Jonathan R. Halstead, Clive D'Santos

Publikováno v: The EMBO Journal. 19:5440-5449

Phosphoinositides are localized in various intracellular compartments and can regulate a number of intracellular functions, such as cytoskeletal dynamics and membrane trafficking. Phospholipase Ds (PLDs) are regulated enzymes that hydrolyse phosphati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81ee38c6b125d017d2f8ce9ffcc42a8
https://doi.org/10.1093/emboj/19.20.5440

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Nuclear inositides: inconsistent consistencies

Autor: Jonathan R. Halstead, Clive D'Santos, Mieke Roefs, Nullin Divecha, Jonathan H. Clarke

Publikováno v: Cellular and Molecular Life Sciences. 57:379-393

It is now clear that phosphoinositides, which play a major role in the regulation of a variety of cellular processes in the cytoplasm, are found within the nucleus. Their role in this subcellular compartment is still contentious: however, data has su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99279db0f99a6b4f4f9922c97e41b90f
https://doi.org/10.1007/pl00000700

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A family 26 mannanase produced by Clostridium thermocellum as a component of the cellulosome contains a domain which is conserved in mannanases from anaerobic fungi The GenBank/EMBL accession number for the sequence reported in this paper is AJ242666

Autor: Harry J. Gilbert, Philip E. Vercoe, Jonathan R. Halstead, Geoffrey P. Hazlewood, Keith Davidson

Publikováno v: Microbiology. 145:3101-3108

Cellulosomes prepared by the cellulose affinity digestion method from Clostridium thermocellum culture supernatant hydrolysed carob galactomannan during incubation at 60 °C and pH 6·5. A recombinant phage expressing mannanase activity was isolated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f87134f1fd3b8c2daba18c67e1ea56b
https://doi.org/10.1099/00221287-145-11-3101

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Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction

Autor: Willem-Jan Keune, Nullin Divecha, Clive D'Santos, Iman van den Bout, David R. Jones, Shabaz Mohammed, Jonathan R. Halstead, Zahid H. Shah

Publikováno v: The Biochemical journal. 455(3)

The spatial and temporal regulation of the second messenger PtdIns(4,5) P 2 has been shown to be crucial for regulating numerous processes in the cytoplasm and in the nucleus. Three isoforms of PIP5K1 (phosphatidylinositol 4-phosphate 5-kinase), A, B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56211004415d10143a532779c31ac29e
http://ora.ox.ac.uk/objects/uuid:63101beb-cfb3-40fb-a82e-497cf75cdf6f

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Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics

Autor: Jonathan R, Halstead, Nicolai E, Savaskan, Iman, van den Bout, Francis, Van Horck, Amra, Hajdo-Milasinovic, Mireille, Snell, Willem-Jan, Keune, Jean-Paul, Ten Klooster, Peter L, Hordijk, Nullin, Divecha

Publikováno v: Journal of cell science. 123(Pt 20)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd72271a297970456b430586927a0190
https://pubmed.ncbi.nlm.nih.gov/20841379

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Assaying endogenous phosphatidylinositol-4-phosphate 5-kinase (PIP5K) activities

Autor: Jonathan R, Halstead, Mireille H, Snel, Sarah, Meeuws, David R, Jones, Nullin, Divecha

Publikováno v: Methods in molecular biology (Clifton, N.J.). 462

Phosphoinositides are a family of lipid second messengers interlinked by an extensive and highly regulated network of kinases and phosphatases. The modulation of phosphoinositide profiles can regulate numerous cancer-related pathways, including cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff7e82db9ccd90d6acce2a794f074384
https://pubmed.ncbi.nlm.nih.gov/19160683

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