Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jonathan R. Davies"'
Publikováno v:
FEBS Open Bio, Vol 10, Iss 8, Pp 1474-1481 (2020)
Clostridium botulinum neurotoxins (BoNTs) cause flaccid paralysis through inhibition of acetylcholine release from motor neurons; however, at tiny doses, this property is exploited for use as a therapeutic. Each member of the BoNT family of proteins
Externí odkaz:
https://doaj.org/article/5de009e49ba743fe96fe659728df4766
Publikováno v:
Toxins, Vol 14, Iss 1, p 14 (2021)
Botulinum neurotoxins (BoNTs) are the causative agents of a potentially lethal paralytic disease targeting cholinergic nerve terminals. Multiple BoNT serotypes exist, with types A, B and E being the main cause of human botulism. Their extreme toxicit
Externí odkaz:
https://doaj.org/article/17078774d8d541258ca6b6430c50c185
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8315 (2021)
The botulinum neurotoxins are potent molecules that are not only responsible for the lethal paralytic disease botulism, but have also been harnessed for therapeutic uses in the treatment of an increasing number of chronic neurological and neuromuscul
Externí odkaz:
https://doaj.org/article/21a467aa4f944e298e415dbc1d84f1ec
Publikováno v:
Toxins, Vol 12, Iss 9, p 603 (2020)
Botulinum neurotoxins (BoNTs) can be used therapeutically to treat a wide range of neuromuscular and neurological conditions. A collection of natural BoNT variants exists which can be classified into serologically distinct serotypes (BoNT/B), and fur
Externí odkaz:
https://doaj.org/article/04c31c537e1341debe65b341d2fd1bdd
Publikováno v:
PeerJ, Vol 6, p e4552 (2018)
The binding specificity of botulinum neurotoxins (BoNTs) is primarily a consequence of their ability to bind to multiple receptors at the same time. BoNTs consist of three distinct domains, a metalloprotease light chain (LC), a translocation domain (
Externí odkaz:
https://doaj.org/article/4220cb3abb9f473c8bdcc9788b5693a2
Publikováno v:
Toxins, Vol 10, Iss 10, p 421 (2018)
Botulinum neurotoxins (BoNTs) are categorised into immunologically distinct serotypes BoNT/A to /G). Each serotype can also be further divided into subtypes based on differences in amino acid sequence. BoNTs are ~150 kDa proteins comprised of three m
Externí odkaz:
https://doaj.org/article/6f3794ca526d44c399c18257f1cf17f8
Publikováno v:
FEBS Open Bio, Vol 10, Iss 8, Pp 1474-1481 (2020)
FEBS Open Bio
FEBS Open Bio
Botulinum neurotoxins (BoNTs) cause the deadly condition called botulism, but they can be used as therapeutics for a wide range of indications. BoNTs are classified into many different serotypes and subtypes, each with potentially different intoxicat
Autor:
Jonathan R. Davies
Publikováno v:
The Biochemist. 41:22-25
Almost everyone has heard of Botox, it's one of the brand names of a chemical injected under the skin that can reduce the appearance of wrinkles. However, many people are unaware that the active component of Botox is actually a highly potent neurotox
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 8315, p 8315 (2021)
International journal of molecular sciences 22(15), 8315 (1-12) (2021). doi:10.3390/ijms22158315
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 8315, p 8315 (2021)
International journal of molecular sciences 22(15), 8315 (1-12) (2021). doi:10.3390/ijms22158315
International journal of molecular sciences 22(15), 8315 (1-12) (2021). doi:10.3390/ijms22158315
The botulinum neurotoxins are potent molecules that are not only responsible for the lethal paralytic disease botulism, but have also been harnessed
The botulinum neurotoxins are potent molecules that are not only responsible for the lethal paralytic disease botulism, but have also been harnessed
Publikováno v:
Toxins, Vol 10, Iss 10, p 421 (2018)
Toxins
Toxins
Botulinum neurotoxins (BoNTs) are categorised into immunologically distinct serotypes BoNT/A to /G). Each serotype can also be further divided into subtypes based on differences in amino acid sequence. BoNTs are ~150 kDa proteins comprised of three m