Zobrazeno 1 - 10
of 338
pro vyhledávání: '"Jonathan R T, Lakey"'
Autor:
Alexandra M. Smink, Bryan Ceballos, Taco Koster, Samuel Rodriquez, Michael Alexander, Jonathan R. T. Lakey, Paul de Vos
Publikováno v:
Macromol, Vol 2, Iss 3, Pp 476-484 (2022)
Subcutaneous polymer scaffolds have shown potential for creating an optimal transplantation site in cellular replacement therapy, e.g., when transplanting insulin-producing cells to cure type 1 diabetes. Imperative for these scaffolds is a high degre
Externí odkaz:
https://doaj.org/article/d3797e0f52ff46dc992c474107057367
Autor:
Jonathan R. T. Lakey, Yanmin Wang, Michael Alexander, Mike K. S. Chan, Michelle B. F. Wong, Krista Casazza, Ian Jenkins
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15713 (2023)
The scourge of type-1 diabetes (T1D) is the morbidity and mortality it and its complications cause at a younger age. This propels the constant search for better diagnostic, treatment, and management strategies, with the ultimate quest being a cure fo
Externí odkaz:
https://doaj.org/article/985e9f5b157b4e16914de97c22759ea4
Autor:
Yanmin Wang, Michael Alexander, Todd Scott, Desiree C. T. Cox, Augusta Wellington, Mike K. S. Chan, Michelle B. F. Wong, Orn Adalsteinsson, Jonathan R. T. Lakey
Publikováno v:
Animals, Vol 13, Iss 15, p 2457 (2023)
Stem cell therapy is an attractive treatment for diseases in companion animals that cannot be treated by conventional veterinary medicine practices. The unique properties of stem cells, particularly the ability to differentiate into specific cell typ
Externí odkaz:
https://doaj.org/article/4112bee54e28435ebb481f92bf3832be
Autor:
Stanley T. Lewis, Frank Greenway, Tori R. Tucker, Michael Alexander, Levonika K. Jackson, Scott A. Hepford, Brian Loveridge, Jonathan R. T. Lakey
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10927 (2023)
Physiologic insulin secretion consists of an oscillating pattern of secretion followed by distinct trough periods that stimulate ligand and receptor activation. Apart from the large postprandial bolus release of insulin, β cells also secrete small a
Externí odkaz:
https://doaj.org/article/15df2676f8eb4bf1999eceea450dfaa5
Autor:
M. Rezaa Mohammadi, Samuel Mathew Rodriguez, Jennifer Cam Luong, Shiri Li, Rui Cao, Hamad Alshetaiwi, Hien Lau, Hayk Davtyan, Mathew Blurton Jones, Mahtab Jafari, Kai Kessenbrock, S. Armando Villalta, Paul de Vos, Weian Zhao, Jonathan R. T. Lakey
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Mohammadi et al. show that the transplantation of pancreatic islets within mesenchymal-stem cell (MSC) exosome-loaded hybrid alginate microcapsules in diabetic mice lead to diminished immune-based foreign body response and hyperglycemia control. This
Externí odkaz:
https://doaj.org/article/2679dce50030425f97c4feb28fe920b9
Autor:
Farshid Eslami-Kaliji, Niloufar Hedayat Nia, Jonathan R. T. Lakey, Alexandra M. Smink, Mohammadreza Mohammadi
Publikováno v:
Polymers, Vol 15, Iss 5, p 1313 (2023)
Long term function of implantable biomaterials are determined by their integration with the host’s body. Immune reactions against these implants could impair the function and integration of the implants. Some biomaterial-based implants lead to macr
Externí odkaz:
https://doaj.org/article/b3bc2b54c6954cf282c560b6da06e15c
Autor:
Natsuki Eguchi, Kimia Damyar, Michael Alexander, Donald Dafoe, Jonathan R. T. Lakey, Hirohito Ichii
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1038 (2022)
Islet cell transplantation has become a favorable therapeutic approach in the treatment of Type 1 Diabetes due to the lower surgical risks and potential complications compared to conventional pancreas transplantation. Despite significant improvements
Externí odkaz:
https://doaj.org/article/1fa150c4484c40daaa3bda57175ec678
Autor:
Hien Lau, Nicole Corrales, Samuel Rodriguez, Colleen Luong, Mohammadreza Mohammadi, Veria Khosrawipour, Shiri Li, Michael Alexander, Paul de Vos, Jonathan R T Lakey
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243506 (2020)
Previous studies have shown that necrostatin-1 (Nec-1) supplementation improved the viability of murine islets following exposure to nitric oxide, increased the survival of human islets during hypoxic culture, and augmented the maturation of pre-wean
Externí odkaz:
https://doaj.org/article/f27280d80f76487d9d2d7caed55ab4b4
Autor:
Frank Greenway, Brian Loveridge, Richard M. Grimes, Tori R. Tucker, Michael Alexander, Scott A. Hepford, Justin Fontenot, Candi Nobles-James, Carol Wilson, Adam M. Starr, Mohammed Abdelsaid, Stanley T. Lewis, Jonathan R. T. Lakey
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1884 (2022)
Prevalence of type 2 diabetes increased from 2.5% of the US population in 1990 to 10.5% in 2018. This creates a major public health problem, due to increases in long-term complications of diabetes, including neuropathy, retinopathy, nephropathy, skin
Externí odkaz:
https://doaj.org/article/e381995a0f8f448eb12671968f9d2a57
Publikováno v:
Cell Transplantation, Vol 28 (2019)
The limited availability of human islets has led to the examination of porcine islets as a source of clinically suitable tissue for transplantation in patients with diabetes mellitus. Islets from porcine donors are commonly used in both in vitro and
Externí odkaz:
https://doaj.org/article/568a0fd50e0246ee98bf5e25c4fe3366