Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Jonathan R Lai"'
Autor:
Ariel S Wirchnianski, Elisabeth K Nyakatura, Andrew S Herbert, Ana I Kuehne, Shawn A Abbasi, Catalina Florez, Nadia Storm, Lindsay G A McKay, Leandrew Dailey, Erin Kuang, Dafna M Abelson, Anna Z Wec, Srinjoy Chakraborti, Frederick W Holtsberg, Sergey Shulenin, Zachary A Bornholdt, M Javad Aman, Anna N Honko, Anthony Griffiths, John M Dye, Kartik Chandran, Jonathan R Lai
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012134 (2024)
Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as well as the capacity to induce immune-mediated virus clearance. Their activities can be furth
Externí odkaz:
https://doaj.org/article/2302156227ee41508fe68701e955e1ae
Autor:
Ryan J Malonis, George I Georgiev, Denise Haslwanter, Laura A VanBlargan, Georgia Fallon, Olivia Vergnolle, Sean M Cahill, Richard Harris, David Cowburn, Kartik Chandran, Michael S Diamond, Jonathan R Lai
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010573 (2022)
Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe neuroinvasive disease. Currently, there are no approved treatments or vaccines to combat POWV infection. Here, we generated and characterized a nanoparticle immunoge
Externí odkaz:
https://doaj.org/article/cd4057e1ec1c4b8f86ac31bc376dde61
Autor:
Gorka Lasso, Saad Khan, Stephanie A Allen, Margarette Mariano, Catalina Florez, Erika P Orner, Jose A Quiroz, Gregory Quevedo, Aldo Massimi, Aditi Hegde, Ariel S Wirchnianski, Robert H Bortz, Ryan J Malonis, George I Georgiev, Karen Tong, Natalia G Herrera, Nicholas C Morano, Scott J Garforth, Avinash Malaviya, Ahmed Khokhar, Ethan Laudermilch, M Eugenia Dieterle, J Maximilian Fels, Denise Haslwanter, Rohit K Jangra, Jason Barnhill, Steven C Almo, Kartik Chandran, Jonathan R Lai, Libusha Kelly, Johanna P Daily, Olivia Vergnolle
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009778 (2022)
The clinical outcome of SARS-CoV-2 infection varies widely between individuals. Machine learning models can support decision making in healthcare by assessing fatality risk in patients that do not yet show severe signs of COVID-19. Most predictive mo
Externí odkaz:
https://doaj.org/article/6e20ef620826496397e91cdbc58ba169
Autor:
Jose A Quiroz, Ryan J Malonis, Larissa B Thackray, Courtney A Cohen, Jesper Pallesen, Rohit K Jangra, Rebecca S Brown, Daniel Hofmann, Frederick W Holtsberg, Sergey Shulenin, Elisabeth K Nyakatura, Lorellin A Durnell, Vinayak Rayannavar, Johanna P Daily, Andrew B Ward, M Javad Aman, John M Dye, Kartik Chandran, Michael S Diamond, Margaret Kielian, Jonathan R Lai
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008061 (2019)
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes persistent arthritis in a subset of human patients. We report the isolation and functional characterization of monoclonal antibodies (mAbs) from two patients infected with CHI
Externí odkaz:
https://doaj.org/article/a598088c3c3f4bc283f5f862aa24c25e
Autor:
Yun Liu, Chelsea D Higgins, Cathie M Overstreet, Kanti R Rai, Nicholas Chiorazzi, Jonathan R Lai
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 245-252 (2013)
Abstract Chronic lymphocytic leukemia (CLL) is a clonal disease of a subset of human B lymphocytes. Although the cause of the disease is unknown, its development and evolution appear to be promoted by signals delivered when B-cell receptors (BCRs) en
Externí odkaz:
https://doaj.org/article/44dff80b8c844996bd1311a60cf3d3f2
Publikováno v:
Heliyon, Vol 5, Iss 12, Pp e03018- (2019)
Fusion of host and viral membranes is a crucial step during infection by enveloped viruses. In the structurally-defined “class I″ viral glycoproteins, the formation of a highly stable α-helical bundle by the ectodomain of the fusion subunit (e.g
Externí odkaz:
https://doaj.org/article/88e0fc27349c42b0b3da94250547d8be
Autor:
Adam G. Kreutzer, Gretchen Guaglianone, Stan Yoo, Chelsea Marie T. Parrocha, Sarah M. Ruttenberg, Ryan J. Malonis, Karen Tong, Yu-Fu Lin, Jennifer T. Nguyen, William J. Howitz, Michelle N. Diab, Imane L. Hamza, Jonathan R. Lai, Vicki H. Wysocki, James S. Nowick
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The assembly of the β-amyloid peptide (Aβ) to form oligomers and fibrils is closely associated with the pathogenesis and progression of Alzheimer’s disease. Aβ is a shape-shifting peptide capable of adopting many conformations and folds within t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8a8b8c19344edb7a9eb68d6eb71519
https://doi.org/10.1073/pnas.2219216120
https://doi.org/10.1073/pnas.2219216120
Autor:
Katie A. Howell, Xiangguo Qiu, Jennifer M. Brannan, Christopher Bryan, Edgar Davidson, Frederick W. Holtsberg, Anna Z. Wec, Sergey Shulenin, Julia E. Biggins, Robin Douglas, Sven G. Enterlein, Hannah L. Turner, Jesper Pallesen, Charles D. Murin, Shihua He, Andrea Kroeker, Hong Vu, Andrew S. Herbert, Marnie L. Fusco, Elisabeth K. Nyakatura, Jonathan R. Lai, Zhen-Yong Keck, Steven K.H. Foung, Erica Ollmann Saphire, Larry Zeitlin, Andrew B. Ward, Kartik Chandran, Benjamin J. Doranz, Gary P. Kobinger, John M. Dye, M. Javad Aman
Publikováno v:
Cell Reports, Vol 15, Iss 7, Pp 1514-1526 (2016)
Summary: Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surface. We report a monoclonal antibody (FVM0
Externí odkaz:
https://doaj.org/article/8cb2b4542b0546a695db88b408e10d26
Autor:
Delphi Chatterjee, Tingting Chen, Todd L. Lowary, Jacqueline M. Achkar, Devin T. Corrigan, Anita G. Amin, Jonathan R. Lai, Maju Joe, Elise Ishida, Ryan J. Malonis, Daniel Hofmann
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
The surface polysacharide arabinomannan (AM) and related glycolipid lipoarabinomannan (LAM) play critical roles in tuberculosis pathogenesis. Human antibody responses to AM/LAM are heterogenous and knowledge of reactivity to specific glycan epitopes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd27b5f925e0204cf11d1f92e7545f7a
https://doaj.org/article/beed135280764d7ba72204f728213be0
https://doaj.org/article/beed135280764d7ba72204f728213be0
Autor:
Lucia R. Wolgast, Ethan Laudermilch, Erika P. Orner, Evan M. Cadoff, Yungtai Lo, Catalina Florez, D. Yitzchak Goldstein, George I. Georgiev, Robert H. Bortz, Louis M. Weiss, Michael B. Prystowsky, Sean T Campbell, Jason Barnhill, Amy S. Fox, Ryan J. Malonis, Stefanie K. Forest, Jonathan R. Lai, Ariel S. Wirchnianski, Olivia Vergnolle, Kartik Chandran
Publikováno v:
Archives of Pathology & Laboratory Medicine. 145:929-936
Context.— Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) testing is used for serosurveillance and will be important to evaluate vaccination status. Given the urgency to release coronavirus disease 2019 (COVID-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d609304ad13f6a4a43cc43b06bc9e146
https://doi.org/10.5858/arpa.2020-0851-sa
https://doi.org/10.5858/arpa.2020-0851-sa