Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Jonathan R Lai"'
Autor:
Ariel S Wirchnianski, Elisabeth K Nyakatura, Andrew S Herbert, Ana I Kuehne, Shawn A Abbasi, Catalina Florez, Nadia Storm, Lindsay G A McKay, Leandrew Dailey, Erin Kuang, Dafna M Abelson, Anna Z Wec, Srinjoy Chakraborti, Frederick W Holtsberg, Sergey Shulenin, Zachary A Bornholdt, M Javad Aman, Anna N Honko, Anthony Griffiths, John M Dye, Kartik Chandran, Jonathan R Lai
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012134 (2024)
Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as well as the capacity to induce immune-mediated virus clearance. Their activities can be furth
Externí odkaz:
https://doaj.org/article/2302156227ee41508fe68701e955e1ae
Autor:
Ryan J Malonis, George I Georgiev, Denise Haslwanter, Laura A VanBlargan, Georgia Fallon, Olivia Vergnolle, Sean M Cahill, Richard Harris, David Cowburn, Kartik Chandran, Michael S Diamond, Jonathan R Lai
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010573 (2022)
Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe neuroinvasive disease. Currently, there are no approved treatments or vaccines to combat POWV infection. Here, we generated and characterized a nanoparticle immunoge
Externí odkaz:
https://doaj.org/article/cd4057e1ec1c4b8f86ac31bc376dde61
Autor:
Gorka Lasso, Saad Khan, Stephanie A Allen, Margarette Mariano, Catalina Florez, Erika P Orner, Jose A Quiroz, Gregory Quevedo, Aldo Massimi, Aditi Hegde, Ariel S Wirchnianski, Robert H Bortz, Ryan J Malonis, George I Georgiev, Karen Tong, Natalia G Herrera, Nicholas C Morano, Scott J Garforth, Avinash Malaviya, Ahmed Khokhar, Ethan Laudermilch, M Eugenia Dieterle, J Maximilian Fels, Denise Haslwanter, Rohit K Jangra, Jason Barnhill, Steven C Almo, Kartik Chandran, Jonathan R Lai, Libusha Kelly, Johanna P Daily, Olivia Vergnolle
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009778 (2022)
The clinical outcome of SARS-CoV-2 infection varies widely between individuals. Machine learning models can support decision making in healthcare by assessing fatality risk in patients that do not yet show severe signs of COVID-19. Most predictive mo
Externí odkaz:
https://doaj.org/article/6e20ef620826496397e91cdbc58ba169
Autor:
Jose A Quiroz, Ryan J Malonis, Larissa B Thackray, Courtney A Cohen, Jesper Pallesen, Rohit K Jangra, Rebecca S Brown, Daniel Hofmann, Frederick W Holtsberg, Sergey Shulenin, Elisabeth K Nyakatura, Lorellin A Durnell, Vinayak Rayannavar, Johanna P Daily, Andrew B Ward, M Javad Aman, John M Dye, Kartik Chandran, Michael S Diamond, Margaret Kielian, Jonathan R Lai
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008061 (2019)
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes persistent arthritis in a subset of human patients. We report the isolation and functional characterization of monoclonal antibodies (mAbs) from two patients infected with CHI
Externí odkaz:
https://doaj.org/article/a598088c3c3f4bc283f5f862aa24c25e
Autor:
Yun Liu, Chelsea D Higgins, Cathie M Overstreet, Kanti R Rai, Nicholas Chiorazzi, Jonathan R Lai
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 245-252 (2013)
Abstract Chronic lymphocytic leukemia (CLL) is a clonal disease of a subset of human B lymphocytes. Although the cause of the disease is unknown, its development and evolution appear to be promoted by signals delivered when B-cell receptors (BCRs) en
Externí odkaz:
https://doaj.org/article/44dff80b8c844996bd1311a60cf3d3f2
Autor:
Natalia G. Herrera, Nicholas C. Morano, Alev Celikgil, George I. Georgiev, Ryan J. Malonis, James H. Lee, Karen Tong, Olivia Vergnolle, Aldo B. Massimi, Laura Y. Yen, Alex J. Noble, Mykhailo Kopylov, Jeffrey B. Bonanno, Sarah C. Garrett-Thomson, David B. Hayes, Robert H. Bortz, Ariel S. Wirchnianski, Catalina Florez, Ethan Laudermilch, Denise Haslwanter, J. Maximilian Fels, M. Eugenia Dieterle, Rohit K. Jangra, Jason Barnhill, Amanda Mengotto, Duncan Kimmel, Johanna P. Daily, Liise-anne Pirofski, Kartik Chandran, Michael Brenowitz, Scott J. Garforth, Edward T. Eng, Jonathan R. Lai, Steven C. Almo
Publikováno v:
ACS Omega, Vol 6, Iss 1, Pp 85-102 (2020)
Externí odkaz:
https://doaj.org/article/8225fcf771154e9c93f8122d956b1bc4
Autor:
Denise Haslwanter, M. Eugenia Dieterle, Anna Z. Wec, Cecilia M. O’Brien, Mrunal Sakharkar, Catalina Florez, Karen Tong, C. Garrett Rappazzo, Gorka Lasso, Olivia Vergnolle, Ariel S. Wirchnianski, Robert H. Bortz, Ethan Laudermilch, J. Maximilian Fels, Amanda Mengotto, Ryan J. Malonis, George I. Georgiev, Jose A. Quiroz, Daniel Wrapp, Nianshuang Wang, Kathryn E. Dye, Jason Barnhill, John M. Dye, Jason S. McLellan, Johanna P. Daily, Jonathan R. Lai, Andrew S. Herbert, Laura M. Walker, Kartik Chandran, Rohit K. Jangra
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
The U.S. FDA has issued emergency use authorizations (EUAs) for multiple investigational monoclonal antibody (MAb) therapies for the treatment of mild to moderate COVID-19.
Externí odkaz:
https://doaj.org/article/679d11cbba69478ca30bdf9534e81939
Autor:
Robert H. Bortz, Catalina Florez, Ethan Laudermilch, Ariel S. Wirchnianski, Gorka Lasso, Ryan J. Malonis, George I. Georgiev, Olivia Vergnolle, Natalia G. Herrera, Nicholas C. Morano, Sean T. Campbell, Erika P. Orner, Amanda Mengotto, M. Eugenia Dieterle, J. Maximilian Fels, Denise Haslwanter, Rohit K. Jangra, Alev Celikgil, Duncan Kimmel, James H. Lee, Margarette C. Mariano, Antonio Nakouzi, Jose Quiroz, Johanna Rivera, Wendy A. Szymczak, Karen Tong, Jason Barnhill, Mattias N. E. Forsell, Clas Ahlm, Daniel T. Stein, Liise-anne Pirofski, D. Yitzchak Goldstein, Scott J. Garforth, Steven C. Almo, Johanna P. Daily, Michael B. Prystowsky, James D. Faix, Amy S. Fox, Louis M. Weiss, Jonathan R. Lai, Kartik Chandran
Publikováno v:
mSphere, Vol 6, Iss 2 (2021)
Serological surveillance has become an important public health tool during the COVID-19 pandemic. Detection of protective antibodies and seroconversion after SARS-CoV-2 infection or vaccination can help guide patient care plans and public health poli
Externí odkaz:
https://doaj.org/article/e39dcb00b9d340e68f1fa28b382e7f53
Publikováno v:
Heliyon, Vol 5, Iss 12, Pp e03018- (2019)
Fusion of host and viral membranes is a crucial step during infection by enveloped viruses. In the structurally-defined “class I″ viral glycoproteins, the formation of a highly stable α-helical bundle by the ectodomain of the fusion subunit (e.g
Externí odkaz:
https://doaj.org/article/88e0fc27349c42b0b3da94250547d8be
Autor:
Adam G. Kreutzer, Gretchen Guaglianone, Stan Yoo, Chelsea Marie T. Parrocha, Sarah M. Ruttenberg, Ryan J. Malonis, Karen Tong, Yu-Fu Lin, Jennifer T. Nguyen, William J. Howitz, Michelle N. Diab, Imane L. Hamza, Jonathan R. Lai, Vicki H. Wysocki, James S. Nowick
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The assembly of the β-amyloid peptide (Aβ) to form oligomers and fibrils is closely associated with the pathogenesis and progression of Alzheimer’s disease. Aβ is a shape-shifting peptide capable of adopting many conformations and folds within t