Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Jonathan R Keller"'
Autor:
Masa-Aki Nakaya, Kristibjorn Orri Gudmundsson, Yuko Komiya, Jonathan R Keller, Raymond Habas, Terry P Yamaguchi, Rieko Ajima
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0232025 (2020)
The actin cytoskeleton plays a central role in establishing cell polarity and shape during embryonic morphogenesis. Daam1, a member of the Formin family of actin cytoskeleton regulators, is a Dvl2-binding protein that functions in the Wnt/Planar Cell
Externí odkaz:
https://doaj.org/article/f4c22a5cdb07467a95dc308dbc4b34b0
Autor:
Yurong Song, Teresa Sullivan, Kimberly Klarmann, Debra Gilbert, T Norene O'Sullivan, Lucy Lu, Sophie Wang, Diana C Haines, Terry Van Dyke, Jonathan R Keller
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171510 (2017)
Thymic epithelial cells (TEC), as part of thymic stroma, provide essential growth factors/cytokines and self-antigens to support T cell development and selection. Deletion of Rb family proteins in adult thymic stroma leads to T cell hyperplasia in vi
Externí odkaz:
https://doaj.org/article/74a1c8fcec9f4ec7800e95969bda3f34
Autor:
Arun Prakash Mishra, Suzanne A. Hartford, Sounak Sahu, Kimberly Klarmann, Rajani Kant Chittela, Kajal Biswas, Albert B. Jeon, Betty K. Martin, Sandra Burkett, Eileen Southon, Susan Reid, Mary E. Albaugh, Baktiar Karim, Lino Tessarollo, Jonathan R. Keller, Shyam K. Sharan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Mishra et al. have generated mice with a single amino acid substitution in BRCA2, which disrupts its interaction with DSS1 resulting in a severe HR defect. They show the interaction to be dispensable for HR at replication induced and meiotic DSBs.
Externí odkaz:
https://doaj.org/article/13f8d0d242734c8aae14e9ee7e9dbb0c
Autor:
Velayoudame Parthibane, Diwash Acharya, Sargur Madabushi Srideshikan, Jing Lin, Dru G. Myerscough, Thiruvaimozhi Abimannan, Nagampalli Vijaykrishna, Daniel Blankenberg, Lavanya Bondada, Kimberly D. Klarmann, Stephen D. Fox, Thorkell Andresson, Lino Tessarollo, Usha Acharya, Jonathan R. Keller, Jairaj K. Acharya
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3635-3649 (2019)
Abstract: Serine palmitoyltransferase (SPT) long-chain base subunit 1 (SPTLC1) is 1 of the 2 main catalytic subunits of the SPT complex, which catalyzes the first and rate-limiting step of sphingolipid biosynthesis. Here, we show that Sptlc1 deletion
Externí odkaz:
https://doaj.org/article/f462def89ff74bea9877599f90c861ed
Autor:
Shweta, Singh, Tanmoy, Sarkar, Brad, Jakubison, Stephen, Gadomski, Andrew, Spradlin, Kristbjorn O, Gudmundsson, Jonathan R, Keller
Publikováno v:
Frontiers in Immunology. 13
Adult mammalian hematopoiesis is a dynamic cellular process that provides a continuous supply of myeloid, lymphoid, erythroid/megakaryocyte cells for host survival. This process is sustained by regulating hematopoietic stem cells (HSCs) quiescence, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb3c74e2e4ee54e849b1840ae66bc9c
https://doi.org/10.3389/fimmu.2022.934624
https://doi.org/10.3389/fimmu.2022.934624
Autor:
Tanmoy Sarkar, Jennifer Lombardo, Shweta Singh, Kristbjorn O Gudmundsson, Holly M Morris, Shyam Saran, Jonathan R Keller
Publikováno v:
Blood Cancer Discovery. 4:A55-A55
Acute myeloid leukemia (AML) is thought to be maintained by quiescent leukemia stem cells (LSCs), which are resistant to chemotherapy and responsible for relapse. Recent evidence suggests that a subset of LSCs with higher oxidative phosphorylation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5e2b678bb68b595c18772456b059037
https://doi.org/10.1158/2643-3249.aml23-a55
https://doi.org/10.1158/2643-3249.aml23-a55
Autor:
Jonathan R. Keller, Anthony T. Tubbs, André Nussenzweig, Can Wang, Jianke Ren, Xiaoping Xu, Yafeng He, Lei Sun, Andrew Schwader, Kathrin Muegge, Kimberly D. Klarmann, Richard Finney, Kai Ni
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance ICF4 is an inherited disease with early mortality due to immunodeficiency. Although the genetic cause is known to be a mutation in the Lsh (lymphoid-specific helicase) gene, it remains unknown why patients suffer from an impaired immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8babefa2143d9a8529388111ce771218
http://europepmc.org/articles/PMC7443918
http://europepmc.org/articles/PMC7443918
Publikováno v:
Current Opinion in Hematology. 27:225-231
Purpose of review Hematopoietic stem cells (HSCs) are defined by their ability to self-renew and differentiate to replenish all blood lineages throughout adult life. Under homeostasis, the majority of HSCs are quiescent, and few stem cells are cyclin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1d283598981381387b6f3927bd67cb
https://doi.org/10.1097/moh.0000000000000586
https://doi.org/10.1097/moh.0000000000000586
Autor:
Arun Prakash Mishra, Suzanne A. Hartford, Sounak Sahu, Kimberly Klarmann, Rajani Kant Chittela, Kajal Biswas, Albert B. Jeon, Betty K. Martin, Sandra Burkett, Eileen Southon, Susan Reid, Mary E. Albaugh, Baktiar Karim, Lino Tessarollo, Jonathan R. Keller, Shyam K. Sharan
Publikováno v:
Nature communications. 13(1)
The interaction between tumor suppressor BRCA2 and DSS1 is essential for RAD51 recruitment and repair of DNA double stand breaks (DSBs) by homologous recombination (HR). We have generated mice with a leucine to proline substitution at position 2431 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e70b63bffda9ce94432e0cdb3da695
https://pubmed.ncbi.nlm.nih.gov/35365640
https://pubmed.ncbi.nlm.nih.gov/35365640
Autor:
Brad L. Jakubison, Tanmoy Sarkar, Kristbjorn O. Gudmundsson, Shweta Singh, Lei Sun, Holly M. Morris, Kimberly D. Klarmann, Jonathan R. Keller
Publikováno v:
The Journal of clinical investigation. 132(13)
Defining mechanism(s) that maintain tissue stem quiescence is important for improving tissue regeneration, cell therapies, aging, and cancer. We report here that genetic ablation of Id2 in adult hematopoietic stem cells (HSCs) promotes increased HSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6bf8c360200fda77f6983b41ab0193
https://pubmed.ncbi.nlm.nih.gov/35775482
https://pubmed.ncbi.nlm.nih.gov/35775482