Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Jonathan R Keller"'
Autor:
Masa-Aki Nakaya, Kristibjorn Orri Gudmundsson, Yuko Komiya, Jonathan R Keller, Raymond Habas, Terry P Yamaguchi, Rieko Ajima
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0232025 (2020)
The actin cytoskeleton plays a central role in establishing cell polarity and shape during embryonic morphogenesis. Daam1, a member of the Formin family of actin cytoskeleton regulators, is a Dvl2-binding protein that functions in the Wnt/Planar Cell
Externí odkaz:
https://doaj.org/article/f4c22a5cdb07467a95dc308dbc4b34b0
Autor:
Yurong Song, Teresa Sullivan, Kimberly Klarmann, Debra Gilbert, T Norene O'Sullivan, Lucy Lu, Sophie Wang, Diana C Haines, Terry Van Dyke, Jonathan R Keller
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171510 (2017)
Thymic epithelial cells (TEC), as part of thymic stroma, provide essential growth factors/cytokines and self-antigens to support T cell development and selection. Deletion of Rb family proteins in adult thymic stroma leads to T cell hyperplasia in vi
Externí odkaz:
https://doaj.org/article/74a1c8fcec9f4ec7800e95969bda3f34
Autor:
Reut Suliman-Lavie, Ben Title, Yahel Cohen, Nanako Hamada, Maayan Tal, Nitzan Tal, Galya Monderer-Rothkoff, Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Jonathan R. Keller, Guo-Jen Huang, Koh-ichi Nagata, Yosef Yarom, Sagiv Shifman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
POGZ is an autism spectrum disorder risk gene. How POGZ mutations result in ASD is unclear and animal models are lacking. Here, the authors generate a brain specific Pogz deficient mouse presenting ASD-like behaviour and show the effects of Pogz defi
Externí odkaz:
https://doaj.org/article/14ea55860cc94204933e8e502705deac
Autor:
Velayoudame Parthibane, Diwash Acharya, Sargur Madabushi Srideshikan, Jing Lin, Dru G. Myerscough, Thiruvaimozhi Abimannan, Nagampalli Vijaykrishna, Daniel Blankenberg, Lavanya Bondada, Kimberly D. Klarmann, Stephen D. Fox, Thorkell Andresson, Lino Tessarollo, Usha Acharya, Jonathan R. Keller, Jairaj K. Acharya
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3635-3649 (2019)
Abstract: Serine palmitoyltransferase (SPT) long-chain base subunit 1 (SPTLC1) is 1 of the 2 main catalytic subunits of the SPT complex, which catalyzes the first and rate-limiting step of sphingolipid biosynthesis. Here, we show that Sptlc1 deletion
Externí odkaz:
https://doaj.org/article/f462def89ff74bea9877599f90c861ed
Autor:
Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Kimberly D. Klarmann, Satyendra K. Singh, Lei Sun, Shweta Singh, Yang Du, Vincenzo Coppola, Luke Stockwin, Nhu Nguyen, Lino Tessarollo, Leifur Thorsteinsson, Olafur E. Sigurjonsson, Sveinn Gudmundsson, Thorunn Rafnar, John F. Tisdale, Jonathan R. Keller
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3236-3248 (2018)
Summary: Fetal globin genes are transcriptionally silenced during embryogenesis through hemoglobin switching. Strategies to derepress fetal globin expression in the adult could alleviate symptoms in sickle cell disease and β-thalassemia. We identifi
Externí odkaz:
https://doaj.org/article/e0d1e32368d04fa6970dd5594931da2a
Autor:
Reut Suliman-Lavie, Ben Title, Yahel Cohen, Nanako Hamada, Maayan Tal, Nitzan Tal, Galya Monderer-Rothkoff, Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Jonathan R. Keller, Guo-Jen Huang, Koh-ichi Nagata, Yosef Yarom, Sagiv Shifman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/86f6f8a5fa734315aa46b75ea5b936d2
Autor:
Xia Ding, Arnab Ray Chaudhuri, Elsa Callen, Yan Pang, Kajal Biswas, Kimberly D. Klarmann, Betty K. Martin, Sandra Burkett, Linda Cleveland, Stacey Stauffer, Teresa Sullivan, Aashish Dewan, Hanna Marks, Anthony T. Tubbs, Nancy Wong, Eugen Buehler, Keiko Akagi, Scott E. Martin, Jonathan R. Keller, André Nussenzweig, Shyam K. Sharan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss.
Externí odkaz:
https://doaj.org/article/cf505f822a744ac9ab12008610c61b55
Autor:
Shweta, Singh, Tanmoy, Sarkar, Brad, Jakubison, Stephen, Gadomski, Andrew, Spradlin, Kristbjorn O, Gudmundsson, Jonathan R, Keller
Publikováno v:
Frontiers in Immunology. 13
Adult mammalian hematopoiesis is a dynamic cellular process that provides a continuous supply of myeloid, lymphoid, erythroid/megakaryocyte cells for host survival. This process is sustained by regulating hematopoietic stem cells (HSCs) quiescence, p
Autor:
Tanmoy Sarkar, Jennifer Lombardo, Shweta Singh, Kristbjorn O Gudmundsson, Holly M Morris, Shyam Saran, Jonathan R Keller
Publikováno v:
Blood Cancer Discovery. 4:A55-A55
Acute myeloid leukemia (AML) is thought to be maintained by quiescent leukemia stem cells (LSCs), which are resistant to chemotherapy and responsible for relapse. Recent evidence suggests that a subset of LSCs with higher oxidative phosphorylation an
Autor:
Jonathan R. Keller, Anthony T. Tubbs, André Nussenzweig, Can Wang, Jianke Ren, Xiaoping Xu, Yafeng He, Lei Sun, Andrew Schwader, Kathrin Muegge, Kimberly D. Klarmann, Richard Finney, Kai Ni
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance ICF4 is an inherited disease with early mortality due to immunodeficiency. Although the genetic cause is known to be a mutation in the Lsh (lymphoid-specific helicase) gene, it remains unknown why patients suffer from an impaired immune