Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jonathan R Grover"'
Autor:
Susan A. Leonhardt, Michael D. Purdy, Jonathan R. Grover, Ziwei Yang, Sandra Poulos, William E. McIntire, Elizabeth A. Tatham, Satchal K. Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D. Uchil, Andrés Finzi, Alan Rein, Anthony A. Kossiakoff, Walther Mothes, Mark Yeager
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates incorporation of SERINCs via binding to intracellular loop 4 (IC
Externí odkaz:
https://doaj.org/article/b42d4618236b4cabb367d4bb3ff2f26d
Autor:
Yaozong Chen, Jérémie Prévost, Irfan Ullah, Hugo Romero, Veronique Lisi, William D. Tolbert, Jonathan R. Grover, Shilei Ding, Shang Yu Gong, Guillaume Beaudoin-Bussières, Romain Gasser, Mehdi Benlarbi, Dani Vézina, Sai Priya Anand, Debashree Chatterjee, Guillaume Goyette, Michael W. Grunst, Ziwei Yang, Yuxia Bo, Fei Zhou, Kathie Béland, Xiaoyun Bai, Allison R. Zeher, Rick K. Huang, Dung N. Nguyen, Rebekah Sherburn, Di Wu, Grzegorz Piszczek, Bastien Paré, Doreen Matthies, Di Xia, Jonathan Richard, Priti Kumar, Walther Mothes, Marceline Côté, Pradeep D. Uchil, Vincent-Philippe Lavallée, Martin A. Smith, Marzena Pazgier, Elie Haddad, Andrés Finzi
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105783- (2023)
Summary: Neutralizing antibodies (NAbs) hold great promise for clinical interventions against SARS-CoV-2 variants of concern (VOCs). Understanding NAb epitope-dependent antiviral mechanisms is crucial for developing vaccines and therapeutics against
Externí odkaz:
https://doaj.org/article/4347d7b5ecc4456ca4f762f55082f32d
Autor:
Yuanyun Ao, Jonathan R. Grover, Yang Han, Guohua Zhong, Wenyi Qin, Dibya Ghimire, Anzarul Haque, Rajanya Bhattacharjee, Baoshan Zhang, James Arthos, Edward A. Lemke, Peter D. Kwong, Maolin Lu
Publikováno v:
bioRxiv
The HIV-1 envelope (Env) glycoprotein is conformationally dynamic and mediates membrane fusion required for cell entry. Single-molecule fluorescence resonance energy transfer (smFRET) of Env using peptide tags has provided mechanistic insights into t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650eee3e3c7062847a943bf4ef213502
https://europepmc.org/articles/PMC10002649/
https://europepmc.org/articles/PMC10002649/
Autor:
Wenwei Li, Elizabeth Nand, Zhuan Qin, Michael W. Grunst, Jonathan R. Grover, Julian W. Bess, Jeffrey D. Lifson, Michael B. Zwick, Hemant D. Tagare, Pradeep D. Uchil, Walther Mothes
Human immunodeficiency virus 1 (HIV-1) infection is initiated by binding of the viral envelope glycoprotein (Env) to the cell-surface receptor CD4. Although high resolution structures of Env complexed with soluble domains of CD4 have been determined,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8000cc523cc459f90e09cbbdfcd7d21f
https://doi.org/10.1101/2022.12.23.521843
https://doi.org/10.1101/2022.12.23.521843
Autor:
Yaozong Chen, Jérémie Prévost, Irfan Ullah, Hugo Romero, Veronique Lisi, William D. Tolbert, Jonathan R. Grover, Shilei Ding, Shang Yu Gong, Guillaume Beaudoin-Bussières, Romain Gasser, Mehdi Benlarbi, Dani Vézina, Sai Priya Anand, Debashree Chatterjee, Guillaume Goyette, Michael W. Grunst, Ziwei Yang, Yuxia Bo, Fei Zhou, Kathie Béland, Xiaoyun Bai, Allison R. Zeher, Rick K. Huang, Dung N. Nguyen, Rebekah Sherburn, Di Wu, Grzegorz Piszczek, Bastien Paré, Doreen Matthies, Di Xia, Jonathan Richard, Priti Kumar, Walther Mothes, Marceline Côté, Pradeep D. Uchil, Vincent-Philippe Lavallée, Martin A. Smith, Marzena Pazgier, Elie Haddad, Andrés Finzi
Publikováno v:
iScience. 26(1)
Neutralizing antibodies (NAbs) hold great promise for clinical interventions against SARS-CoV-2 variants of concern (VOCs). Understanding NAb epitope-dependent antiviral mechanisms is crucial for developing vaccines and therapeutics against VOCs. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0562d8ee692a297be811d153a249c3c
https://pubmed.ncbi.nlm.nih.gov/36514310
https://pubmed.ncbi.nlm.nih.gov/36514310
Autor:
Susan A. Leonhardt, Michael D. Purdy, Jonathan R. Grover, Ziwei Yang, Sandra Poulos, William E. McIntire, Elizabeth A. Tatham, Satchal Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D. Uchil, Andrés Finzi, Alan Rein, Anthony A. Kossiakoff, Walther Mothes, Mark Yeager
The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates incorporation of SERINCs via binding to intracellular loop 4 (ICL4). Cryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a0d74b95c25bf5e1483f3a421947ded
https://doi.org/10.1101/2022.07.06.498924
https://doi.org/10.1101/2022.07.06.498924
Autor:
Shilei Ding, Irfan Ullah, Shang Yu Gong, Jonathan R. Grover, Mohammadjavad Mohammadi, Yaozong Chen, Dani Vézina, Guillaume Beaudoin-Bussières, Vijay Tailor Verma, Guillaume Goyette, Fleur Gaudette, Jonathan Richard, Derek Yang, Amos B. Smith, Marzena Pazgier, Marceline Côté, Cameron Abrams, Priti Kumar, Walther Mothes, Pradeep D. Uchil, Andrés Finzi, Christian Baron
Publikováno v:
bioRxiv
SummarySARS-CoV-2 infection of host cells starts by binding of the Spike glycoprotein (S) to the ACE2 receptor. The S-ACE2 interaction is a potential target for therapies against COVID-19 as demonstrated by the development of immunotherapies blocking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e127fee33a9acf34b0b0671c6f21e1
https://doi.org/10.1101/2022.02.03.479007
https://doi.org/10.1101/2022.02.03.479007
Autor:
Peter D. Kwong, Brennan P. Carman, Andrés Finzi, Dongjun Peng, Walther Mothes, Daniel S. Terry, Joseph Sodroski, Amos B. Smith, Baoshan Zhang, Cameron F. Abrams, Jason Gorman, Michael Farzan, Nick Reichard, Maolin Lu, Utz Ermel, Tongqing Zhou, Luis R. Castillo-Menendez, Akihiro Sugawara, Kevin Wang, Jonathan R. Grover, James Arthos, Scott C. Blanchard, James B. Munro, Michael Chambers, Adrian B. McDermott, Ivana Nikić-Spiegel, Edward A. Lemke, Xiaochu Ma, Matthew R. Gardner, Nirmin Alsahafi
Publikováno v:
Nature
The HIV-1 envelope glycoprotein (Env) trimer mediates cell entry and is conformationally dynamic1-8. Imaging by single-molecule fluorescence resonance energy transfer (smFRET) has revealed that, on the surface of intact virions, mature pre-fusion Env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66785f30afa4ad33e5181894467368c
https://doi.org/10.1038/s41586-019-1101-y
https://doi.org/10.1038/s41586-019-1101-y
Autor:
Scott C. Blanchard, Andrés Finzi, Wei Shi, Peter D. Kwong, Guillaume Beaudoin-Bussières, John R. Mascola, Walther Mothes, Annemarie Laumaea, Romain Gasser, Daniel S. Terry, Wenwei Li, Desheng Zheng, Lihong Liu, Sai Priya Anand, David D. Ho, Jérémie Prévost, Tongqing Zhou, Jason Gorman, Maolin Lu, Jonathan R. Grover, Shilei Ding, Pradeep D. Uchil, Baoshan Zhang
Publikováno v:
Cell Host & Microbe
bioRxiv
bioRxiv
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) mediates viral entry into cells and is critical for vaccine development against coronavirus disease 2019 (COVID-19). Structural studies have revealed distinct conformations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d7fb2d0ccb51f8e91a4fa440c1f2c2
Autor:
Mohammadjavad Mohammadi, Shitao Zou, Cameron F. Abrams, Haitao Ding, Navid Madani, Joseph Sodroski, Hanh T. Nguyen, Saumya Anang, Walther Mothes, Amos B. Smith, Shijian Zhang, Jonathan R. Grover, Mark Farrell, Althea Gaffney, John C. Kappes, Maolin Lu, Scott C. Blanchard, Meiqing Zhao, Connie Zhao
Publikováno v:
J Virol
During human immunodeficiency virus type 1 (HIV-1) entry into cells, the viral envelope glycoprotein (Env) trimer [(gp120/gp41)(3)] binds the receptors CD4 and CCR5 and fuses the viral and cell membranes. CD4 binding changes Env from a pretriggered (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd6a5f80ef630f63295b1acb57fa717
https://doi.org/10.1128/jvi.00148-20
https://doi.org/10.1128/jvi.00148-20