Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Jonathan R Chubb"'
Publikováno v:
eLife, Vol 12 (2023)
Cells use signal relay to transmit information across tissue scales. However, the production of information carried by signal relay remains poorly characterised. To determine how the coding features of signal relay are generated, we used the classic
Externí odkaz:
https://doaj.org/article/f9719c2f3cf9425b9c2a0366e1b1542f
Autor:
John ME Nichols, Vlatka Antolović, Jacob D Reich, Sophie Brameyer, Peggy Paschke, Jonathan R Chubb
Publikováno v:
eLife, Vol 9 (2020)
Dedifferentiation is a critical response to tissue damage, yet is not well understood, even at a basic phenomenological level. Developing Dictyostelium cells undergo highly efficient dedifferentiation, completed by most cells within 24 hr. We use thi
Externí odkaz:
https://doaj.org/article/7cab134f6343447b90b5ebf49ea698a8
Autor:
Peggy Paschke, David A Knecht, Augustinas Silale, David Traynor, Thomas D Williams, Peter A Thomason, Robert H Insall, Jonathan R Chubb, Robert R Kay, Douwe M Veltman
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196809 (2018)
Dictyostelium has a mature technology for molecular-genetic manipulation based around transfection using several different selectable markers, marker re-cycling, homologous recombination and insertional mutagenesis, all supported by a well-annotated
Externí odkaz:
https://doaj.org/article/e50838345c6640ac94a37f459c8aab21
Publikováno v:
eLife, Vol 5 (2016)
Transcription occurs in stochastic bursts. Early models based upon RNA hybridisation studies suggest bursting dynamics arise from alternating inactive and permissive states. Here we investigate bursting mechanism in live cells by quantitative imaging
Externí odkaz:
https://doaj.org/article/1e07e531046c432f99fb9cf8125512f7
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11560 (2010)
Despite the distinctive structure of mitotic chromosomes, it has not been possible to visualise individual chromosomes in living interphase cells, where chromosomes spend over 90% of their time. Studies of interphase chromosome structure and dynamics
Externí odkaz:
https://doaj.org/article/e5e44c02ed854d34b06080e91af24ecb
Autor:
Lee E Finlan, Duncan Sproul, Inga Thomson, Shelagh Boyle, Elizabeth Kerr, Paul Perry, Bauke Ylstra, Jonathan R Chubb, Wendy A Bickmore
Publikováno v:
PLoS Genetics, Vol 4, Iss 3, p e1000039 (2008)
The spatial organisation of the genome in the nucleus has a role in the regulation of gene expression. In vertebrates, chromosomal regions with low gene-density are located close to the nuclear periphery. Correlations have also been made between the
Externí odkaz:
https://doaj.org/article/abb8d042e58d40e483ff2b91450a4691
Development can proceed in “fits and starts”, with rapid transitions between cell states involving concerted transcriptome-wide changes in gene expression. However, it is not clear how these transitions are regulated in complex cell populations,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f5f6e92f961f57d8afc180303a99fb
https://doi.org/10.1101/2023.05.03.539233
https://doi.org/10.1101/2023.05.03.539233
Publikováno v:
Developmental Cell. 56:2142-2144
A persistent view of cell fate choices during development entails centralized control by so-called master regulators. A recent single-cell study of the large-scale fate specification during mammalian gastrulation (Mittnenzweig et al., 2021) implies t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f975b2e37b5531ed789035489e85708b
https://doi.org/10.1016/j.devcel.2021.07.007
https://doi.org/10.1016/j.devcel.2021.07.007
Autor:
Edward Tunnacliffe, Jonathan R. Chubb
Publikováno v:
Trends in Genetics. 36:288-297
The idea that gene activity can be discontinuous will not surprise many biologists – many genes are restricted in when and where they can be expressed. Yet during the past 15 years, a collection of observations compiled under the umbrella term ‘t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fcf46e9edadbb3b7d2d3ed29c9c0e9
https://doi.org/10.1016/j.tig.2020.01.003
https://doi.org/10.1016/j.tig.2020.01.003