Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Jonathan R Brestoff"'
Autor:
Wei Zou, Nidhi Rohatgi, Jonathan R Brestoff, Yan Zhang, Erica L Scheller, Clarissa S Craft, Michael D Brodt, Nicole Migotsky, Matthew J Silva, Charles A Harris, Steven L Teitelbaum
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008244 (2019)
Berardinelli-Seip congenital generalized lipodystrophy is associated with increased bone mass suggesting that fat tissue regulates the skeleton. Because there is little mechanistic information regarding this issue, we generated "fat-free" (FF) mice c
Externí odkaz:
https://doaj.org/article/3f85769dcd8146f293a5b9cf73c78f3b
Autor:
Jonathan R Brestoff, Tim Brodsky, Alexandra Z Sosinsky, Ryan McLoughlin, Elena Stansky, Leila Fussell, Aaron Sheppard, Maria DiSanto-Rose, Erin E Kershaw, Thomas H Reynolds
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137388 (2015)
The superoxide dismutase mimetic manganese [III] tetrakis [5,10,15,20]-benzoic acid porphyrin (MnTBAP) is a potent antioxidant compound that has been shown to limit weight gain during short-term high fat feeding without preventing insulin resistance.
Externí odkaz:
https://doaj.org/article/d293d28cafd547e9af5e97eddd9905c5
Publikováno v:
Trends in Cell Biology. 33:517-529
Brown adipose tissue (BAT) controls mammalian core body temperature by non-shivering thermogenesis. BAT is extraordinarily rich in mitochondria, which have the peculiarity of generating heat by uncoupled respiration. Since the mitochondrial activity
Autor:
Vahid Azimi, Michael Slade, Mark Fiala, Julie M Fortier, Keith Stockerl-Goldstein, John L Frater, Jonathan R Brestoff, Ronald Jackups, Mark A Zaydman
Publikováno v:
Clinical Chemistry. 69:595-605
Background Serum free light chain (sFLC) assays are interpreted using a sFLC-ratio-based reference interval (manufacturer’s interval) that was defined using a cohort of healthy patients. However, renal impairment elevates the sFLC-ratio, leading to
Autor:
Yongjia Li, Xinming Su, Nidhi Rohatgi, Yan Zhang, Jonathan R. Brestoff, Kooresh I. Shoghi, Yalin Xu, Clay F. Semenkovich, Charles A. Harris, Lindsay L. Peterson, Katherine N. Weilbaecher, Steven L. Teitelbaum, Wei Zou
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
Obesity predisposes to cancer and a virtual universality of nonalcoholic fatty liver disease (NAFLD). However, the impact of hepatic steatosis on liver metastasis is enigmatic. We find that while control mice were relatively resistant to hepatic meta
Externí odkaz:
https://doaj.org/article/823957cb09a84ffc8fbd4f0dac29a9b4
Autor:
Yaoheng Yang, Jinyun Yuan, Rachael L. Field, Dezhuang Ye, Zhongtao Hu, Kevin Xu, Lu Xu, Yan Gong, Yimei Yue, Alexxai V. Kravitz, Michael R. Bruchas, Jianmin Cui, Jonathan R. Brestoff, Hong Chen
Publikováno v:
Nature Metabolism.
Torpor is an energy-conserving state in which animals dramatically decrease their metabolic rate and body temperature to survive harsh environmental conditions. Here, we report the noninvasive, precise and safe induction of a torpor-like hypothermic
Autor:
Jonathan R. Brestoff
Publikováno v:
International Journal of Laboratory Hematology.
Publikováno v:
International Journal of Laboratory Hematology. 44:45-53
Involvement of the central nervous system (CNS) by acute leukemias (ALs) has important implications for risk stratification and disease outcome. The clinical laboratory plays an essential role in assessment of cerebrospinal fluid (CSF) specimens from
Autor:
Andrew LaPoint, Jason M. Singer, Daniel Ferguson, Trevor M. Shew, M. Katie Renkemeyer, Hector Palacios, Rachael Field, Mahalakshmi Shankaran, Gordon I. Smith, Jun Yoshino, Mai He, Gary J. Patti, Marc K. Hellerstein, Samuel Klein, Jonathan R. Brestoff, Brian N. Finck, Andrew J. Lutkewitte
Publikováno v:
bioRxiv
Dysfunctional adipose tissue is believed to promote the development of hepatic steatosis and systemic insulin resistance, but many of the mechanisms involved are still unclear. Lipin 1 catalyzes the conversion of phosphatidic acid to diacylglycerol (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33734f1b0a3139892daf97f77c28f2b
https://europepmc.org/articles/PMC9915639/
https://europepmc.org/articles/PMC9915639/
SummaryB cells are critical for adaptive immunity and are governed by the recognition of an antigen by the B cell receptor (BCR), a process that drives a coordinated series of signaling events and modulation of various transcriptional programs. Singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::966cdd58c96481895294c8db21b5e850
https://doi.org/10.1101/2022.11.09.515787
https://doi.org/10.1101/2022.11.09.515787