Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Jonathan R, Lamb"'
Autor:
Yao-Yao Chang, Qiu-Chan Huan, Jiao Peng, Wen-Chun Bi, Li-Xiang Zhai, Yan Chen, Jonathan R. Lamb, Xiang-Chun Shen, Zhao-Xiang Bian, Hai-qiang Wu, Yong-Xian Cheng, Hai-Tao Xiao
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
P2Y1 receptor is a G-protein-coupled receptor that plays a critical role in the immune response of inflammatory bowel diseases. However, its regulatory effects on CD4+ T cell response have not been fully elucidated. The study aimed to characterize th
Externí odkaz:
https://doaj.org/article/cc7e37bef5144770b6e79c07ace7872f
Autor:
Ruizhong Zhang, Liang Su, Ming Fu, Zhe Wang, Ledong Tan, Hongjiao Chen, Zefeng Lin, Yanlu Tong, Sige Ma, Rongchen Ye, Ziyang Zhao, Ziqing Wang, Weiyi Chen, Jiakang Yu, Wei Zhong, Jixiao Zeng, Fei Liu, Chenwei Chai, Xisi Guan, Tao Liu, Jiankun Liang, Yun Zhu, Xiaoqiong Gu, Yan Zhang, Vincent C.H. Lui, Paul K.H. Tam, Jonathan R. Lamb, Zhe Wen, Yan Chen, Huimin Xia
Publikováno v:
Journal of Hepatology. 77:1299-1310
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::129897bced0fb5b7230c186252c85c50
https://doi.org/10.1016/j.jhep.2022.06.015
https://doi.org/10.1016/j.jhep.2022.06.015
Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia
Autor:
Paul K.H. Tam, Ruizhong Zhang, Yan Chen, Yan Zhang, Ledong Tan, Jonathan R. Lamb, Zefeng Lin, Huimin Xia, Vincent C.H. Lui, Fu Ming
Publikováno v:
Clinical Science (London, England : 1979)
Biliary atresia (BA) is an immune-related disorder and signal transducer and activator of transcription 3 (STAT3) is a key signalling molecule in inflammation. The present study was designed to clarify the function of STAT3 in BA. STAT3 expression wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbf625a40b6431c73531eba2577a14e
http://europepmc.org/articles/PMC8035628
http://europepmc.org/articles/PMC8035628
Autor:
Ruizhong, Zhang, Liang, Su, Ming, Fu, Zhe, Wang, Ledong, Tan, Hongjiao, Chen, Zefeng, Lin, Yanlu, Tong, Sige, Ma, Rongchen, Ye, Ziyang, Zhao, Ziqing, Wang, Weiyi, Chen, Jiakang, Yu, Wei, Zhong, Jixiao, Zeng, Fei, Liu, Chenwei, Chai, Xisi, Guan, Tao, Liu, Jiankun, Liang, Yun, Zhu, Xiaoqiong, Gu, Yan, Zhang, Vincent C H, Lui, Paul K H, Tam, Jonathan R, Lamb, Zhe, Wen, Yan, Chen, Huimin, Xia
Publikováno v:
Journal of hepatology. 77(5)
We have previously reported on the potential pathogenic role of neutrophils in biliary atresia (BA). Herein, we aimed to delineate the role of CD177+ neutrophils in the pathogenesis of BA.Immune cells from the livers of mice with rhesus rotavirus-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7768737b169e7b82c332bf7688feb041
https://pubmed.ncbi.nlm.nih.gov/35803543
https://pubmed.ncbi.nlm.nih.gov/35803543
Autor:
Maggie Dallman, Marie-Christine Ramel, Laurence Bugeon, Schymeinsky J, Progatzky F, Jonathan R. Lamb, Williams C, Madina Wane, Rydlova A, Jung B, M.J. Thomas
The study of respiratory tissue damage and repair is critical to understand not only the consequences of respiratory tissue exposure to infectious agents, irritants and toxic chemicals, but also to comprehend the pathogenesis of chronic inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acd4f8bad4013c148ac0d036e9d8831a
https://doi.org/10.1101/2021.05.27.445469
https://doi.org/10.1101/2021.05.27.445469
Autor:
Jonathan R. Lamb, Yan Zhang, Ming Fu, Zefeng Lin, Vincent Ch Lui, Yan Chen, Ruizhong Zhang, Paul Kh Tam, Huimin Xia
Publikováno v:
SSRN Electronic Journal.
Background: Biliary atresia (BA) is an immune-related disorder, possibly with genetic predisposition. STAT3 is a key signalling molecule in inflammation. This study was to clarify the function of STAT3 in BA. Methods: STAT3 expression was examined in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44a013982d3b66c33eedb17a51156f4b
https://doi.org/10.2139/ssrn.3671419
https://doi.org/10.2139/ssrn.3671419
Autor:
Daxu Li, Julia Y S Tsang, Jiao Peng, Derek H H Ho, Yee Kwan Chan, Jiang Zhu, Vincent C H Lui, Aimin Xu, Jonathan R Lamb, Paul K H Tam, Yan Chen
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48893 (2012)
BACKGROUND: Adiponectin regulates glucose and fatty-acid metabolism but its role in chronic graft rejection mediated by Th2 cytokines remains ill-defined. METHODOLOGY/PRINCIPAL FINDINGS: Wild type and adiponectin-null mice were used as graft recipien
Externí odkaz:
https://doaj.org/article/605f674bea39437eaa8261a9f6608b33
Autor:
Huimin Xia, Vincent C.H. Lui, Wei Zhong, Jiakang Yu, Xi-Si Guan, Zefeng Lin, Ming Fu, Jixiao Zeng, Ruizhong Zhang, Paul K.H. Tam, Yan Chen, Jonathan R. Lamb
Publikováno v:
The American Journal of Pathology. 188:2617-2628
Activation of innate immunity together with cholangiocyte damage occurs in biliary atresia (BA). However, detailed information on the inflammatory cells involved is lacking. This study investigates both the pathophysiology of CD11b+Gr-1+ cells in a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2725fc27f8da7380a74409899aa24f20
https://doi.org/10.1016/j.ajpath.2018.07.024
https://doi.org/10.1016/j.ajpath.2018.07.024
Autor:
Vincent Ch Lui, Huimin Xia, Ming-Fu, Zefeng Lin, Yanlu Tong, Jonathan R. Lamb, Xinhao Zeng, Ruizhong Zhang, Paul Kh Tam, Yan Chen
Publikováno v:
World Journal of Gastroenterology
AIM To analyze the expression and function of the Notch signaling target gene Hes1 in a rhesus rotavirus-induced mouse biliary atresia model. METHODS The morphologies of biliary epithelial cells in biliary atresia patients and in a mouse model were e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6db3e092a55b50149277f4cc5d70a0a
http://europepmc.org/articles/PMC6079292
http://europepmc.org/articles/PMC6079292
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 310:L551-L561
Inflammatory diseases of the respiratory system such as asthma and chronic obstructive pulmonary disease are increasing globally and remain poorly understood conditions. Although attention has long focused on the activation of type 1 and type 2 helpe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4788fdd856e7cb9409c9920db955f3c8
https://doi.org/10.1152/ajplung.00323.2015
https://doi.org/10.1152/ajplung.00323.2015