Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Jonathan P. Wallis"'
Autor:
Erhan Aptullahoglu, Sirintra Nakjang, Jonathan P. Wallis, Helen Marr, Scott Marshall, Elaine Willmore, John Lunec
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1388 (2024)
Chronic lymphocytic leukemia (CLL) is a genetically and clinically diverse hematological cancer affecting middle-aged and elderly individuals. Novel targeted therapy options are needed for patients who relapse following initial responses or who are i
Externí odkaz:
https://doaj.org/article/d985462f94fb48a19b17942c67dfd921
Autor:
Erhan Aptullahoglu, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11335 (2023)
Chronic lymphocytic leukemia (CLL) is a genetically and clinically heterogeneous malignancy affecting older individuals. There are a number of current treatment options for CLL, including monoclonal antibodies, targeted drugs, chemotherapy, and diffe
Externí odkaz:
https://doaj.org/article/996f7e0a42974ae6920e29d3628f2072
Autor:
Erhan Aptullahoglu, Carmela Ciardullo, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2410 (2023)
Several molecular subtypes of cancer are highly dependent on splicing for cell survival. There is a general interest in the therapeutic targeting of splicing by small molecules. E7107, a first-in-class spliceosome inhibitor, showed strong growth inhi
Externí odkaz:
https://doaj.org/article/6f9040da79ba4efb994e204cb3e28ff1
Publikováno v:
AIMS Microbiology, Vol 4, Iss 2, Pp 209-224 (2018)
Mastitis is one of the most important diseases threatening modern dairy herds. The idea of fighting the disease through colonising the udder with lactic acid bacteria (LAB), thereby building a beneficial biofilm, is the base for a probiotic approach
Externí odkaz:
https://doaj.org/article/efcfbcf29f9040789606a2355d496c1d
Publikováno v:
Foods, Vol 8, Iss 2, p 79 (2019)
Mastitis poses a considerable threat to productivity and to animal welfare on modern dairy farms. However, the common way of antibiotic treatment does not always lead to a cure. Unsuccessful cures can, among other reasons, occur due to biofilm format
Externí odkaz:
https://doaj.org/article/445f89cf43c549a7b9990f9ee29dc2a5
Publikováno v:
Frontiers in Systems Neuroscience, Vol 9 (2015)
A prominent account of prefrontal cortex (PFC) function is that single neurons within the PFC maintain representations of task-relevant stimuli in working memory. Evidence for this view comes from studies in which subjects hold a stimulus across a de
Externí odkaz:
https://doaj.org/article/10b9aa0ebdc74a9fb22fdd8a5e724458
Autor:
Laurence T Hunt, Timothy EJ Behrens, Takayuki Hosokawa, Jonathan D Wallis, Steven W Kennerley
Publikováno v:
eLife, Vol 4 (2015)
Activity in prefrontal cortex (PFC) has been richly described using economic models of choice. Yet such descriptions fail to capture the dynamics of decision formation. Describing dynamic neural processes has proven challenging due to the problem of
Externí odkaz:
https://doaj.org/article/1a80779bf1994336936e876742ea398a
Autor:
Fadhel M. Lafta, Laura Woodhouse, Gordon Strathdee, Helen Marr, Scott Marshall, Elaine Willmore, Timothy M. Barrow, Susan J. Tudhope, Kateryna Bilotkach, Nick Bown, Jonathan P. Wallis, Sirintra Nakjang, Gesa Junge
Publikováno v:
British Journal of Cancer
Background Chronic lymphocytic leukaemia (CLL) patients display a highly variable clinical course, with progressive acquisition of drug resistance. We sought to identify aberrant epigenetic traits that are enriched following exposure to treatment tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f87eb3bbb057e5a9ebd0c2ce8c9643
http://sure.sunderland.ac.uk/id/eprint/12635/1/Barrow_BrJCancer_combined_final.pdf
http://sure.sunderland.ac.uk/id/eprint/12635/1/Barrow_BrJCancer_combined_final.pdf
Autor:
Colin Shepherd, Nicola J. Sunter, Paul G. Evans, Rachel Piddock, David Allsup, Helen Marr, Scott Marshall, Claire Elstob, Francesco Forconi, Richard S. Houlston, Syed Ashar Rais, Tryfonia Mainou-Fowler, Thahira Rahman, April Sellors, Chris Pepper, Sandrine Jayne, Alison Bentley, Sarah E. Fordham, Christopher Fegan, Anna Schuh, Peter Hillmen, Martin J. S. Dyer, David Oscier, Wei-Yu Lin, James M. Allan, Lynn Cawkwell, Jonathan P. Wallis, Guy Pratt, James R. Bailey, Geoffrey Summerfield, Andrew R. Pettitt, Gordon Strathdee, Elaine Willmore, Hannah Mearns, Pauline Robbe, Timothy M. Barrow
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data f
Publikováno v:
Transfusion Medicine. 28:284-289
OBJECTIVES The aim of this study is to improve practice in the management of major haemorrhage, particularly in red cell to plasma transfusion ratios. BACKGROUND A review of the management of major haemorrhage in trauma in Newcastle Hospitals Trust i