Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jonathan P. Stoehr"'
Autor:
Alan D. Attie, Ronald M. Krauss, Mark P. Gray-Keller, Alison Brownlie, Makoto Miyazaki, John J. Kastelein, Aldons J. Lusis, Anton F.H. Stalenhoef, Jonathan P. Stoehr, Michael R. Hayden, James M. Ntambi
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 11, Pp 1899-1907 (2002)
Stearoyl-CoA desaturase (SCD) is expressed at high levels in several human tissues and is required for the biosynthesis of oleate (18:1) and palmitoleate (16:1). These monounsaturated fatty acids are the major components of phospholipids, triglycerid
Externí odkaz:
https://doaj.org/article/c9b0aca9a7764e4c88c7c32106c68173
Autor:
Sushant Bhatnagar, Angie T Oler, Mary E Rabaglia, Donald S Stapleton, Kathryn L Schueler, Nathan A Truchan, Sara L Worzella, Jonathan P Stoehr, Susanne M Clee, Brian S Yandell, Mark P Keller, Debbie C Thurmond, Alan D Attie
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002323 (2011)
We previously mapped a type 2 diabetes (T2D) locus on chromosome 16 (Chr 16) in an F2 intercross from the BTBR T (+) tf (BTBR) Lep(ob/ob) and C57BL/6 (B6) Lep(ob/ob) mouse strains. Introgression of BTBR Chr 16 into B6 mice resulted in a consomic mous
Externí odkaz:
https://doaj.org/article/f5f6a4e093c04a5b93c5c3211496fac1
Autor:
Alan D. Attie, Jessica E. Byers, Kathryn L. Schueler, Hong Lan, Igor V. Boronenkov, Susanne M. Clee, Brian S. Yandell, Jonathan P. Stoehr
Publikováno v:
Diabetes. 53:245-249
The adipocyte hormone leptin constitutes an important component of the regulation of energy homeostasis; leptin-deficient animals, such as obese mice, are strikingly overweight. The seemingly uninhibited weight gain in obese mice belies the fact that
Autor:
Samuel T. Nadler, Alan D. Attie, Brian S. Yandell, Hong Lan, Kathryn L. Schueler, Jonathan P. Stoehr
Publikováno v:
Genetics. 164:1607-1614
The advent of sophisticated genomic techniques for gene mapping and microarray analysis has provided opportunities to map mRNA abundance to quantitative trait loci (QTL) throughout the genome. Unfortunately, simple mapping of each individual mRNA tra
Autor:
Kathryn L. Schueler, Samuel T. Nadler, Mary E. Rabaglia, Morris J. Birnbaum, Jonathan P. Stoehr, Alan D. Attie
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 281:E1249-E1254
Insulin stimulates muscle and adipose tissue to absorb glucose through a signaling cascade that is incompletely understood. Insulin resistance, the inability of insulin to appropriately stimulate glucose uptake, is a hallmark of type 2 diabetes melli
Autor:
Jonathan P. Stoehr, Matthew T. Flowers, Donald S. Stapleton, Mary E. Rabaglia, Brian S. Yandell, Daniel M. Klass, Mark P. Gray-Keller, Susanne M. Clee, Hong Lan, Eric Ton-Keen Mui, Summer M. Raines, Igor V. Boronenkov, Philipp W. Raess, Edward A. Kabara, Oliver C. Richards, Alan D. Attie, Kathryn M. Schueler, Matthew B. Young
Publikováno v:
Nature genetics. 38(6)
We previously mapped the type 2 diabetes mellitus-2 locus (T2dm2), which affects fasting insulin levels, to distal chromosome 19 in a leptin-deficient obese F2 intercross derived from C57BL/6 (B6) and BTBR T+ tf/J (BTBR) mice1. Introgression of a 7-M
Autor:
Samuel T. Nadler, Kathryn L. Schueler, Jonathan P. Stoehr, Brian S. Yandell, Hong Lan, Alan D. Attie, Fei Zou, Mary E. Rabaglia
Publikováno v:
Diabetes. 52(3)
Obesity is a strong risk factor for the development of type 2 diabetes. We have previously reported that in adipose tissue of obese (ob/ob) mice, the expression of adipogenic genes is decreased. When made genetically obese, the BTBR mouse strain is d
Autor:
Ronald M. Krauss, Alan D. Attie, Jonathan P. Stoehr, John J.P. Kastelein, James M. Ntambi, Alison J. Brownlie, Mark P. Gray-Keller, Anton F. H. Stalenhoef, Aldons J. Lusis, Michael R. Hayden, Makoto Miyazaki
Publikováno v:
Journal of Lipid Research, 43, 11, pp. 1899-907
Journal of Lipid Research, Vol 43, Iss 11, Pp 1899-1907 (2002)
Journal of Lipid Research, 43, 1899-907
Journal of lipid research, 43(11), 1899-1907. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, Vol 43, Iss 11, Pp 1899-1907 (2002)
Journal of Lipid Research, 43, 1899-907
Journal of lipid research, 43(11), 1899-1907. American Society for Biochemistry and Molecular Biology Inc.
Contains fulltext : 185468.pdf (Publisher’s version ) (Open Access) Stearoyl-CoA desaturase (SCD) is expressed at high levels in several human tissues and is required for the biosynthesis of oleate (18:1) and palmitoleate (16:1). These monounsatura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bbc28e6cfead99ab1222bc159ec230
https://hdl.handle.net/2066/185468
https://hdl.handle.net/2066/185468
Autor:
Stewart A. Metz, Jonathan P. Stoehr, Kathryn L. Schueler, Brian S. Yandell, Samuel T. Nadler, Alan D. Attie, Mary E. Rabaglia
Publikováno v:
Diabetes. 49(11)
Nonlinear interactions between obesity and genetic risk factors are thought to determine susceptibility to type 2 diabetes. We used genetic obesity as a tool to uncover latent differences in diabetes susceptibility between two mouse strains, C57BL/6J
Autor:
Alan D. Attie, Kathryn L. Schueler, Brian S. Yandell, Jonathan P. Stoehr, Gene Tanimoto, Samuel T. Nadler
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 97(21)
Obesity is strongly correlated with type 2 diabetes mellitus, a common disorder of glucose and lipid metabolism. Although adipocytes are critical in obesity, their role in diabetes has only recently been appreciated. We conducted studies by using DNA