Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Jonathan P. Sleeman"'
Autor:
Michael Albrecht, Carsten Sticht, Tabea Wagner, Steffen A. Hettler, Carolina De La Torre, Jiedong Qiu, Norbert Gretz, Thomas Albrecht, Benito Yard, Jonathan P. Sleeman, Boyan K. Garvalov
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract In diabetic nephropathy (DN), glomerular endothelial cells (GECs) and podocytes undergo pathological alterations, which are influenced by metabolic changes characteristic of diabetes, including hyperglycaemia (HG) and elevated methylglyoxal
Externí odkaz:
https://doaj.org/article/5f11865b1b404ee3a36eeb1be0df89ad
Autor:
Rafael Saup, Nidhi Nair, Jingyi Shen, Anja Schmaus, Wilko Thiele, Boyan K. Garvalov, Jonathan P. Sleeman
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1038 (2023)
Osteopontin (OPN) is a phosphoprotein with diverse functions in various physiological and pathological processes. OPN expression is increased in multiple cancers, and OPN within tumour tissue has been shown to promote key stages of cancer development
Externí odkaz:
https://doaj.org/article/f4bf4a5a3ad9494086b9d7b787670933
Autor:
Cristina L. Cotarelo, Arno Schad, Marcus Schmidt, Arnd Hönig, Jonathan P. Sleeman, Sonja Thaler
Publikováno v:
Cancers, Vol 15, Iss 6, p 1860 (2023)
Oncogene-induced senescence is thought to constitute a barrier to carcinogenesis by arresting cells at risk of malignant transformation. However, numerous findings suggest that senescent cells may conversely promote tumor growth and metastatic progre
Externí odkaz:
https://doaj.org/article/35493606ad794e72beef9a0522f2bdd1
Publikováno v:
Cancers, Vol 14, Iss 20, p 5093 (2022)
Originally discovered as a hypothetical protein with unknown function, CEMIP (cell migration-inducing and hyaluronan-binding protein) has been implicated in the pathogenesis of numerous diseases, including deafness, arthritis, atherosclerosis, idiopa
Externí odkaz:
https://doaj.org/article/75d0d82e531f4c45b75ebcff011234bd
Autor:
Lenka Kyjacova, Rafael Saup, Melanie Rothley, Anja Schmaus, Tabea Wagner, Anja Boßerhoff, Boyan K. Garvalov, Wilko Thiele, Jonathan P. Sleeman
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 22, p 5459 (2021)
A better understanding of the process of melanoma metastasis is required to underpin the development of novel therapies that will improve patient outcomes. The use of appropriate animal models is indispensable for investigating the mechanisms of mela
Externí odkaz:
https://doaj.org/article/5efdfbfd7d5b4c978300e2058a145c84
Publikováno v:
Cells, Vol 10, Iss 11, p 2868 (2021)
Around 70% of breast cancers express the estrogen receptor alpha (ERα). This receptor is of central importance for breast cancer development and estrogen-dependent tumor growth. However, the molecular mechanisms that are responsible for the control
Externí odkaz:
https://doaj.org/article/e4f6ebe1ff594e199a4765aecaf02fdf
Autor:
Sven Roßwag, Cristina L. Cotarelo, Klaus Pantel, Sabine Riethdorf, Jonathan P. Sleeman, Marcus Schmidt, Sonja Thaler
Publikováno v:
Cancers, Vol 13, Iss 8, p 1810 (2021)
Mechanisms of acquired endocrine resistance and late recurrence in patients with ER+/HER2− breast cancer are complex and not fully understood. Here, we evaluated mechanisms of acquired resistance in circulating tumor cells (CTCs) from an ER+/HER2
Externí odkaz:
https://doaj.org/article/2338aca974ce40e4a34418e0380c03c6
Autor:
Benjamin Thomas, MD, Jan Warzsawski, MD, Florian Falkner, MD, Amir K. Bigdeli, MD, Boyan K. Garvalov, PhD, Arno Dimmler, MD, Jonathan P. Sleeman, PhD, Ulrich Kneser, MD, Volker J. Schmidt, MD, Wilko Thiele, PhD
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 8, Iss 9S, Pp 140-141 (2020)
Externí odkaz:
https://doaj.org/article/7a4c8abcf38a430ca9670077f764c574
Autor:
Dror Alishekevitz, Svetlana Gingis-Velitski, Orit Kaidar-Person, Lilach Gutter-Kapon, Sandra D. Scherer, Ziv Raviv, Emmanuelle Merquiol, Yael Ben-Nun, Valeria Miller, Chen Rachman-Tzemah, Michael Timaner, Yelena Mumblat, Neta Ilan, David Loven, Dov Hershkovitz, Ronit Satchi-Fainaro, Galia Blum, Jonathan P. Sleeman, Israel Vlodavsky, Yuval Shaked
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1344-1356 (2016)
Summary: While chemotherapy strongly restricts or reverses tumor growth, the response of host tissue to therapy can counteract its anti-tumor activity by promoting tumor re-growth and/or metastases, thus limiting therapeutic efficacy. Here, we show t
Externí odkaz:
https://doaj.org/article/33aac968c8234da399706c8ab64ff755
Publikováno v:
Cancers, Vol 12, Iss 9, p 2689 (2020)
The estrogen receptor alpha (ERα) is expressed by the majority of breast cancers and plays an important role in breast cancer development and tumor outgrowth. Although ERα is well known to be a specific and efficient therapeutic target, the molecul
Externí odkaz:
https://doaj.org/article/b253eb1fcdb445d3b05a1aa18ef3d1d5