Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jonathan P. Laye"'
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 107K, In vivo metabolic profile of tumour and liver after administration of ICT2700 to CYP1A1 tumor-bearing mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fa7a3eeadf697425f73382b1b2ff93
https://doi.org/10.1158/1535-7163.22499368.v1
https://doi.org/10.1158/1535-7163.22499368.v1
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
We identify cytochrome P450 1A1 (CYP1A1) as a target for tumor-selective drug development in bladder cancer and describe the characterization of ICT2700, designed to be metabolized from a prodrug to a potent cytotoxin selectively by CYP1A1. Elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e7d993df8c3092c76202f58dfbcd09
https://doi.org/10.1158/1535-7163.c.6536128.v1
https://doi.org/10.1158/1535-7163.c.6536128.v1
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 120K, Representative CYP1A1 activity of the EJ138 bladder cell line and EJ138-1A1 bladder cell line, determined by measurement of Ethoxyresorufin O-de-ethylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d566ccd99f7fb819d8b39d53982cf80
https://doi.org/10.1158/1535-7163.22499371.v1
https://doi.org/10.1158/1535-7163.22499371.v1
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 109K, Methodology for analysis of CYP1 gene and protein expression,Detection of DNA-damage induced gamma-H2AX protein expression, and analysis of ICT2700 metabolism in mouse and human liver ex vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520a633e7c506912b1f2b1a15a04c4c2
https://doi.org/10.1158/1535-7163.22499362
https://doi.org/10.1158/1535-7163.22499362
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 52K, Lack of CYP1 induction by the chloromethylpyrroloindoline ICT2700
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05076c72e09564975269b0cf51d4414
https://doi.org/10.1158/1535-7163.22499356.v1
https://doi.org/10.1158/1535-7163.22499356.v1
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 85k, Expression of CYP1A1 protein in human transitional cell carcinoma (TCC) of the bladder by immunohistochemical analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d0a32d12084077e7d0db0a60ef4948
https://doi.org/10.1158/1535-7163.22499359.v1
https://doi.org/10.1158/1535-7163.22499359.v1
Autor:
Julia Newton-Bishop, D.T. Bishop, David J. Adams, Louise van der Weyden, Jonathan P. Laye, Jörg Reichrath, Juliette A. Randerson-Moor, Mark Harland, Joey M. Diaz, Sally J. O'Shea, Joanna Poźniak, Jérémie Nsengimana, Anastasia Filia, Sathya Muralidhar
Immunohistochemistry of melanoma sections from LMC for VDR expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89bcdb1672e6b10a8d91534a75f3f8a5
https://doi.org/10.1158/0008-5472.22422081
https://doi.org/10.1158/0008-5472.22422081
Autor:
Julia Newton-Bishop, D.T. Bishop, David J. Adams, Louise van der Weyden, Jonathan P. Laye, Jörg Reichrath, Juliette A. Randerson-Moor, Mark Harland, Joey M. Diaz, Sally J. O'Shea, Joanna Poźniak, Jérémie Nsengimana, Anastasia Filia, Sathya Muralidhar
Supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76bcf43e7f8f3ec9546272543c1ea5da
https://doi.org/10.1158/0008-5472.22422069
https://doi.org/10.1158/0008-5472.22422069
Autor:
Julia Newton-Bishop, D.T. Bishop, David J. Adams, Louise van der Weyden, Jonathan P. Laye, Jörg Reichrath, Juliette A. Randerson-Moor, Mark Harland, Joey M. Diaz, Sally J. O'Shea, Joanna Poźniak, Jérémie Nsengimana, Anastasia Filia, Sathya Muralidhar
Legend for Supplementary tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ab615312077b3b88ff2558ae3f8530
https://doi.org/10.1158/0008-5472.22422084.v1
https://doi.org/10.1158/0008-5472.22422084.v1
Autor:
Julia Newton-Bishop, D.T. Bishop, David J. Adams, Louise van der Weyden, Jonathan P. Laye, Jörg Reichrath, Juliette A. Randerson-Moor, Mark Harland, Joey M. Diaz, Sally J. O'Shea, Joanna Poźniak, Jérémie Nsengimana, Anastasia Filia, Sathya Muralidhar
1α,25-Dihydroxyvitamin D3 signals via the vitamin D receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As patients with melanoma commonly avoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70d00dd798add2af5627f10ac4b9f890
https://doi.org/10.1158/0008-5472.c.6511119.v1
https://doi.org/10.1158/0008-5472.c.6511119.v1