Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jonathan P. Bernardini"'
Autor:
Che A. Stafford, Kate E. Lawlor, Valentin J. Heim, Aleksandra Bankovacki, Jonathan P. Bernardini, John Silke, Ueli Nachbur
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1496-1508 (2018)
Summary: Inhibitors of apoptosis (IAPs) proteins are critical regulators of innate immune signaling pathways and therefore have potential as drug targets. X-linked IAP (XIAP) and cellular IAP1 and IAP2 (cIAP1 and cIAP2) are E3 ligases that have been
Externí odkaz:
https://doaj.org/article/9afda12ce0bb402eba6cd4e27fd2c57d
Publikováno v:
Biochemical Society Transactions
The accumulation of misfolded proteins is associated with numerous degenerative conditions, cancers and genetic diseases. These pathological imbalances in protein homeostasis (termed proteostasis), result from the improper triage and disposal of dama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c47cb5f3e24aee7d26054ba57934a1
http://europepmc.org/articles/PMC7924994
http://europepmc.org/articles/PMC7924994
Autor:
Jonathan P. Bernardini, Jörg Gsponer, Paulina M. Budzyńska, Thibault Mayor, Erich R. Kuechler
Publikováno v:
Journal of Molecular Biology. 432:2349-2368
Recently generated proteomic data provides unprecedented insight into stress granule composition and stands as fruitful ground for further analysis. Stress granules are stress-induced biological assemblies that are of keen interest due to being linke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b9507dbbd30fe64dfe4476d861bfcd
https://doi.org/10.1016/j.jmb.2020.02.020
https://doi.org/10.1016/j.jmb.2020.02.020
Autor:
Giuseppi Infusini, Shashank Masaldan, Daisy Lio, Robert L Ninnis, Destiny Dalseno, Ahmad Wardak, Alan S Huang, Ziyan Liu, Grant Dewson, Jonathan P. Bernardini, Richard W Birkinshaw, Peter E. Czabotar, Andrew I. Webb, Jarrod J. Sandow, Iris K. L. Tan
Publikováno v:
The EMBO Journal. 40
BAK and BAX, the effectors of intrinsic apoptosis, each undergo major reconfiguration to an activated conformer that self-associates to damage mitochondria and cause cell death. However, the dynamic structural mechanisms of this reconfiguration in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b9bd798414b6b149b476c1026a71f59
https://doi.org/10.15252/embj.2020107237
https://doi.org/10.15252/embj.2020107237
Autor:
Timothy R Blackmore, Zhong Yan Gan, Rebecca Feltham, Bernhard C. Lechtenberg, Jonathan P. Bernardini, Alan Riboldi-Tunnicliffe, Gregor Ebert, Cody C. Allison, Lachlan W Richardson, David Komander, Huib Ovaa, Theresa Klemm, Marc Pellegrini, Nathan W Kuchel, Guillaume Lessene, Kym N Lowes, Christoph Grohmann, Jeffrey P Mitchell, James P Cooney, Gerbrand J. van der Heden van Noort, Paul P. Geurink, Amanda E. Au, Grant Dewson, Marcel Doerflinger, Dale J Calleja, Peter E. Czabotar, Bernadine Gc Lu, Yuri Shibata, Janet Newman
Publikováno v:
EMBO Journal, 39(18). WILEY
The EMBO Journal
The EMBO Journal
The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein, but also removes ubiquitin‐like ISG15 protein modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36f05a4438244e4379d16ac47d20c92
https://hdl.handle.net/1887/3182567
https://hdl.handle.net/1887/3182567
Autor:
Christoph Grohmann, Lu Bgc, Jonathan P. Bernardini, Huib Ovaa, Cody C. Allison, Gregor Ebert, Guillaume Lessene, Rebecca Feltham, Dale J Calleja, Marc Pellegrini, David Komander, T. Klemm, Mitchell Jp, Kym N Lowes, Bernhard C. Lechtenberg, James P Cooney, Peter E. Czabotar, Amanda E. Au, Zhong Yan Gan, Paul P. Geurink, Kuchel Nw, Janet Newman, Yuri Shibata, Blackmore Tr, L.W. Richardson, Grant Dewson, Marcel Doerflinger, Alan Riboldi-Tunnicliffe
Coronaviruses, including SARS-CoV-2, encode multifunctional proteases that are essential for viral replication and evasion of host innate immune mechanisms. The papain-like protease PLpro cleaves the viral polyprotein, and reverses inflammatory ubiqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf71356e1581ef4bb08f30febabebb6e
https://doi.org/10.1101/2020.06.18.160614
https://doi.org/10.1101/2020.06.18.160614
Autor:
Yepy H Rustam, Iris K. L. Tan, Eugene A. Kapp, Jonathan P. Bernardini, Grant Dewson, Peter M. Colman, Nicholas A. Smith, Jarrod J. Sandow, Jason M. Brouwer, M.J. Roy, Andrew I. Webb, Gavin E. Reid, Brian J. Smith, Peter E. Czabotar, Angus D. Cowan, Jacqueline M. Gulbis, James M. Murphy, Ahmad Wardak
Publikováno v:
Nature structuralmolecular biology. 27(11)
BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of the mitochondrial outer membrane. Their transition from quiescent monomers to pore-forming oligomers involves a well-char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d09b3adc9911ffb81c34d497964c1f7
https://pubmed.ncbi.nlm.nih.gov/32929280
https://pubmed.ncbi.nlm.nih.gov/32929280
Autor:
Thomas R. Cotton, Simon A. Cobbold, Jonathan P. Bernardini, Lachlan W. Richardson, Xiangyi S. Wang, Bernhard C. Lechtenberg
Publikováno v:
Molecular Cell. 82:598-615.e8
An increasing number of genetic diseases are linked to deregulation of E3 ubiquitin ligases. Loss-of-function mutations in the RING-between-RING (RBR) family E3 ligase RNF216 (TRIAD3) cause Gordon-Holmes syndrome (GHS) and related neurodegenerative d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41cd73dd859024dc760e769975beb80
https://doi.org/10.1016/j.molcel.2021.12.005
https://doi.org/10.1016/j.molcel.2021.12.005
Autor:
Kate E. Lawlor, Aleksandra Bankovacki, Che A. Stafford, Valentin J. Heim, Jonathan P. Bernardini, John Silke, Ueli Nachbur
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1496-1508 (2018)
Summary: Inhibitors of apoptosis (IAPs) proteins are critical regulators of innate immune signaling pathways and therefore have potential as drug targets. X-linked IAP (XIAP) and cellular IAP1 and IAP2 (cIAP1 and cIAP2) are E3 ligases that have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68c8fe5332d498ef0727b9a611ab23c
http://www.sciencedirect.com/science/article/pii/S221112471830041X
http://www.sciencedirect.com/science/article/pii/S221112471830041X
Publikováno v:
The Journal of biological chemistry. 294(45)
Cellular processes accompanying protein aggregation are diverse and entangled, making it difficult to investigate the underlying molecular processes in a time-resolved way. Gottlieb, Thompson, and colleagues address this shortcoming using a chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0d424dd421b5c1065e453711621f77
https://pubmed.ncbi.nlm.nih.gov/31704773
https://pubmed.ncbi.nlm.nih.gov/31704773