Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Jonathan P Stoye"'
Autor:
Ross Hall, Anabel Guedán, Melvyn W Yap, George R Young, Ruth Harvey, Jonathan P Stoye, Kate N Bishop
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010349 (2022)
SARS-CoV-2 is a betacoronavirus and the etiological agent of COVID-19, a devastating infectious disease. Due to its far-reaching effect on human health, there is an urgent and growing need to understand the viral molecular biology of SARS-CoV-2 and i
Externí odkaz:
https://doaj.org/article/b5485d2c26534f929a413fdf09b36359
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008471 (2020)
Viruses and their hosts are locked in an evolutionary race where resistance to infection is acquired by the hosts while viruses develop strategies to circumvent these host defenses. Forming one arm of the host defense armory are cell autonomous restr
Externí odkaz:
https://doaj.org/article/4971c2560ba84ef7a2123799d47f0c3c
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008605 (2020)
As obligate parasites, viruses highjack, modify and repurpose the cellular machinery for their own replication. Viral proteins have, therefore, evolved biological functions, such as signalling potential, that alter host cell physiology in ways that a
Externí odkaz:
https://doaj.org/article/ac05cff782834a99ba6563c911a36410
Autor:
Neil J Ball, Giuseppe Nicastro, Moumita Dutta, Dominic J Pollard, David C Goldstone, Marta Sanz-Ramos, Andres Ramos, Erik Müllers, Kristin Stirnnagel, Nicole Stanke, Dirk Lindemann, Jonathan P Stoye, William R Taylor, Peter B Rosenthal, Ian A Taylor
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005981 (2016)
The Spumaretrovirinae, or foamy viruses (FVs) are complex retroviruses that infect many species of monkey and ape. Despite little sequence homology, FV and orthoretroviral Gag proteins perform equivalent functions, including genome packaging, virion
Externí odkaz:
https://doaj.org/article/9c57cb193dd74b4fa16644edfab5318c
Publikováno v:
PLoS Genetics, Vol 3, Iss 10, Pp 2014-2022 (2007)
The ability of human and murine APOBECs (specifically, APOBEC3) to inhibit infecting retroviruses and retrotransposition of some mobile elements is becoming established. Less clear is the effect that they have had on the establishment of the endogeno
Externí odkaz:
https://doaj.org/article/deea6fa411b249959acdfc42964c3e0d
Autor:
Laurence H Arnold, Harriet C T Groom, Simone Kunzelmann, David Schwefel, Sarah J Caswell, Paula Ordonez, Melanie C Mann, Sabrina Rueschenbaum, David C Goldstone, Simon Pennell, Steven A Howell, Jonathan P Stoye, Michelle Webb, Ian A Taylor, Kate N Bishop
Publikováno v:
PLoS Pathogens, Vol 11, Iss 10, p e1005194 (2015)
SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot function,
Externí odkaz:
https://doaj.org/article/6417b0e1f2764693a511bf12d963870d
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1003968 (2014)
Fv1 is the prototypic restriction factor that protects against infection by the murine leukemia virus (MLV). It was first identified in cells that were derived from laboratory mice and was found to be homologous to the gag gene of an endogenous retro
Externí odkaz:
https://doaj.org/article/4af340c1e96449b9b9620cca6fd699fe
Autor:
David C Goldstone, Thomas G Flower, Neil J Ball, Marta Sanz-Ramos, Melvyn W Yap, Roksana W Ogrodowicz, Nicole Stanke, Juliane Reh, Dirk Lindemann, Jonathan P Stoye, Ian A Taylor
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003376 (2013)
The Spumaretrovirinae, or foamyviruses (FVs) are complex retroviruses that infect many species of monkey and ape. Although FV infection is apparently benign, trans-species zoonosis is commonplace and has resulted in the isolation of the Prototypic Fo
Externí odkaz:
https://doaj.org/article/bf273cf189fd4945879bcf1e69bf50f8
Autor:
George R Young, Mickaël J-Y Ploquin, Urszula Eksmond, Munisch Wadwa, Jonathan P Stoye, George Kassiotis
Publikováno v:
PLoS Pathogens, Vol 8, Iss 5, p e1002709 (2012)
Effective T cell responses can decisively influence the outcome of retroviral infection. However, what constitutes protective T cell responses or determines the ability of the host to mount such responses is incompletely understood. Here we studied t
Externí odkaz:
https://doaj.org/article/428fb6fa436c458cacbf3270d89fb342
Autor:
Sadayuki Ohkura, David C Goldstone, Melvyn W Yap, Kate Holden-Dye, Ian A Taylor, Jonathan P Stoye
Publikováno v:
PLoS Pathogens, Vol 7, Iss 3, p e1002011 (2011)
After entry into target cells, retroviruses encounter the host restriction factors such as Fv1 and TRIM5α. While it is clear that these factors target retrovirus capsid proteins (CA), recognition remains poorly defined in the absence of structural i
Externí odkaz:
https://doaj.org/article/e14623c8542c4a23b9eb1c9c061eed64