Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jonathan P Sherlock"'
Autor:
Anne M. Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Beverly Knight, David Polidori, Aaron Patrick, Trpta Bains, Ruth Steele, Samantha J. Allen, Raymond J. Patch, Chengzao Sun, Sandeep Somani, Ashok Bhandari, David Liu, Keith Huie, Shu Li, Michael A. Rodriguez, Xiaohua Xue, Arun Kannan, Teddy Kosoglou, Jonathan P. Sherlock, Jennifer Towne, M. Claire Holland, Nishit B. Modi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics selectively target this pathway. JNJ-77242113 is a peptide targeting the IL-23 receptor
Externí odkaz:
https://doaj.org/article/a5c225b49e4844578be75fc534d1282c
Autor:
James G. Krueger, Kilian Eyerich, Vijay K. Kuchroo, Christopher T. Ritchlin, Maria T. Abreu, M. Merle Elloso, Anne Fourie, Steven Fakharzadeh, Jonathan P. Sherlock, Ya-Wen Yang, Daniel J. Cua, Iain B. McInnes
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease. We review
Externí odkaz:
https://doaj.org/article/3fb972d7f9ef4534a189cd8ccc187a46
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-5 (2022)
Abstract Current understanding of IL-23 biology, with its link to other pro-inflammatory cytokines, for example, IL-17 and granulocyte macrophage-colony stimulating factor (GM-CSF), is primarily focused on T lymphocyte-mediated inflammation/autoimmun
Externí odkaz:
https://doaj.org/article/3b0359dec86442c99e3fb3a39b4e0d80
Autor:
Jonathan P Sherlock, Daniel J. Cua
Publikováno v:
Rheumatology (Oxford, England)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7f48046d3be5c89134d68c92c7911a
http://europepmc.org/articles/PMC8527240
http://europepmc.org/articles/PMC8527240
Publikováno v:
Arthritis researchtherapy. 24(1)
Current understanding of IL-23 biology, with its link to other pro-inflammatory cytokines, for example, IL-17 and granulocyte macrophage-colony stimulating factor (GM-CSF), is primarily focused on T lymphocyte-mediated inflammation/autoimmunity. Pain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d67ae69caab09987aa836efddcf6d2
https://pubmed.ncbi.nlm.nih.gov/35468842
https://pubmed.ncbi.nlm.nih.gov/35468842
Publikováno v:
Immunological Reviews. 294:27-47
The inflammatory disorders collectively termed the seronegative spondyloarthropathies (SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the arthritis associated with inflammatory bowel disease including Crohn's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7889b949bba46150cb4129ef3a168a8a
https://doi.org/10.1111/imr.12840
https://doi.org/10.1111/imr.12840
Publikováno v:
ANNALS OF THE RHEUMATIC DISEASES
Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that immune responses mediated by interleukin 17A (IL-17A) play a pivotal role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93be7fd3932996330aaf39e858dfb82
https://pubmed.ncbi.nlm.nih.gov/32169970
https://pubmed.ncbi.nlm.nih.gov/32169970
Autor:
Peter C. Taylor, Jonathan P Sherlock
Publikováno v:
Best practiceresearch. Clinical rheumatology. 31(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8812e385915557f081a6b7a6e2604c
https://pubmed.ncbi.nlm.nih.gov/30509438
https://pubmed.ncbi.nlm.nih.gov/30509438
Autor:
Mark Coles, Christopher D. Buckley, Jonathan P Sherlock, Stephanie G. Dakin, Andrew Carr, Fiona Powrie
Publikováno v:
Nature Reviews Rheumatology. 14(11)
Knowledge of how the joint functions as an integrated unit in health and disease requires an understanding of the stromal cells populating the joint mesenchyme, including fibroblasts, tissue-resident macrophages and endothelial cells. Knowledge of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a2b274ac99d8f8fc8bf52b0518858a
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
Current Opinion in Rheumatology. 27:71-75
Interleukin (IL)-23 and the related cytokine IL-17 play vital roles in immune-mediated inflammatory pathology. In the years since its discovery, IL-23 has been implicated as a central pathogenic factor in multiple rheumatic conditions and has been sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b27e7d3506ec19682cd51aeea5a1e52
https://doi.org/10.1097/bor.0000000000000132
https://doi.org/10.1097/bor.0000000000000132