Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jonathan P Lambert"'
Autor:
Pooja Jadiya, Devin W. Kolmetzky, Dhanendra Tomar, Antonio Di Meco, Alyssa A. Lombardi, Jonathan P. Lambert, Timothy S. Luongo, Marthe H. Ludtmann, Domenico Praticò, John W. Elrod
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Dysregulation of intracellular calcium is reported in Alzheimer’s disease. Here the authors show that loss of the mitochondrial Na+ /Ca2 + exchanger, NCLX – primary route of mitochondrial calcium efflux, precedes neuronal pathology in experimenta
Externí odkaz:
https://doaj.org/article/070ff9071c5f47e28fd020946d9949fc
Autor:
Joanne F. Garbincius, Timothy S. Luongo, Jonathan P. Lambert, Adam S. Mangold, Emma K. Murray, Alycia N. Hildebrand, Pooja Jadiya, John W. Elrod
Publikováno v:
bioRxiv
BackgroundMitochondrial calcium (mCa2+) uptake through the mitochondrial calcium uniporter channel (mtCU) stimulates metabolism to meet acute increases in cardiac energy demand. However, excessivemCa2+uptake during stress, as in ischemia-reperfusion,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5922de7c4c56848936d3308c62c1b185
https://doi.org/10.1101/2023.04.17.537222
https://doi.org/10.1101/2023.04.17.537222
Publikováno v:
Journal of Medical Physics, Vol 41, Iss 1, Pp 58-64 (2016)
Monitor units (MUs) calculated by radiotherapy treatment planning systems need to be verified independently. At extended source-surface distances (SSDs), different output factors (OFs) can be given by different independent MU checking packages due to
Externí odkaz:
https://doaj.org/article/9b714f017d5248508718f68ab0f1a924
Autor:
Sergio De La Fuente, Jonathan P. Lambert, Zuzana Nichtova, Celia Fernandez Sanz, John W. Elrod, Shey-Shing Sheu, György Csordás
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3099-3107.e4 (2018)
Summary: Mitochondrial Ca2+ elevations enhance ATP production, but uptake must be balanced by efflux to avoid overload. Uptake is mediated by the mitochondrial Ca2+ uniporter channel complex (MCUC), and extrusion is controlled largely by the Na+/Ca2+
Externí odkaz:
https://doaj.org/article/84a912c7503a491c8bfc9d16084ca19c
Autor:
Timothy S. Luongo, Jonathan P. Lambert, Ancai Yuan, Xueqian Zhang, Polina Gross, Jianliang Song, Santhanam Shanmughapriya, Erhe Gao, Mohit Jain, Steven R. Houser, Walter J. Koch, Joseph Y. Cheung, Muniswamy Madesh, John W. Elrod
Publikováno v:
Cell Reports, Vol 12, Iss 1, Pp 23-34 (2015)
Cardiac contractility is mediated by a variable flux in intracellular calcium (Ca2+), thought to be integrated into mitochondria via the mitochondrial calcium uniporter (MCU) channel to match energetic demand. Here, we examine a conditional, cardiomy
Externí odkaz:
https://doaj.org/article/a56efb7af9a241a9a48dd015464ebe75
Autor:
Joanne F Garbincius, Timothy Luongo, Jonathan P Lambert, Adam S Mangold, Devin Kolmetzky, Emma Murray, Alycia Hildebrand, Pooja Jadiya, Rajika Roy, Mary Nwokedi, Jessica Ibetti, Walter J Koch, John W Elrod
Publikováno v:
Circulation Research. 131
Acute mitochondrial calcium ( m Ca 2+ ) uptake stimulates bioenergetics to meet increased ATP demand, but when excessive predisposes to necrotic cell death. A major unresolved controversy is whether chronic alterations in cardiomyocyte m Ca 2+ homeos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0924ea9321950978fc4b524307b5e81
https://doi.org/10.1161/res.131.suppl_1.p3053
https://doi.org/10.1161/res.131.suppl_1.p3053
Autor:
Daohai Yu, Victor Rizzo, Xiongwen Chen, Jonathan P. Lambert, Markus Wallner, Abdelkarim Sabri, Jaslyn Johnson, Carlos Manuel Romero, Yijun Yang, Claire Poulet, Julia Gorelik, Andrew A. Gibb, Polina Gross, Jose L. Sanchez-Alonso, Joanne F Garbincius, Remus M. Berretta, John W. Elrod, Deborah M Eaton, Erdem Varol, Hajime Kubo, Carla Lucarelli, Jean Ross, Steven R. Houser, Eric Feldsott
Publikováno v:
Circulation Research. 128:92-114
Rationale: Ca 2+ -induced Ca 2+ release (CICR) in normal hearts requires close approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) and RyR (ryanodine receptors) within the junctional sarcoplasmic reticulum. CICR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f26ec0029d7f615793680e9749ea350
https://doi.org/10.1161/circresaha.119.315715
https://doi.org/10.1161/circresaha.119.315715
Autor:
Melanie, Paillard, Kai-Ting, Huang, David, Weaver, Jonathan P, Lambert, John W, Elrod, György, Hajnóczky
Publikováno v:
Cell calcium. 105
Heart failure (HF) is a leading cause of hospitalization and mortality worldwide. Yet, there is still limited knowledge on the underlying molecular mechanisms, because human tissue for research is scarce, and data obtained in animal models is not dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3b3c2957aa99ebb970d563493045eed6
https://pubmed.ncbi.nlm.nih.gov/35779476
https://pubmed.ncbi.nlm.nih.gov/35779476
Autor:
Danielle Murashige, Jae Woo Jung, Michael D. Neinast, Michael G. Levin, Qingwei Chu, Jonathan P. Lambert, Joanne F. Garbincius, Boa Kim, Atsushi Hoshino, Ingrid Marti-Pamies, Kendra S. McDaid, Swapnil V. Shewale, Emily Flam, Steven Yang, Emilia Roberts, Li Li, Michael P. Morley, Kenneth C. Bedi, Matthew C. Hyman, David S. Frankel, Kenneth B. Margulies, Richard K. Assoian, John W. Elrod, Cholsoon Jang, Joshua D. Rabinowitz, Zoltan Arany
Publikováno v:
Cell metabolism. 34(11)
Pharmacologic activation of branched-chain amino acid (BCAA) catabolism is protective in models of heart failure (HF). How protection occurs remains unclear, although a causative block in cardiac BCAA oxidation is widely assumed. Here, we use in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ebd6cb8da1bafa059d4164706e7b36
https://pubmed.ncbi.nlm.nih.gov/36223763
https://pubmed.ncbi.nlm.nih.gov/36223763
Autor:
Pooja Jadiya, Jonathan P. Lambert, Emma K Murray, Joanne F Garbincius, Adam S Mangold, Timothy S. Luongo, Alycia N Hildebrand, John W. Elrod
Publikováno v:
Circulation. 142
Calcium (Ca 2+ ) uptake into the mitochondrial matrix occurs via the mitochondrial Ca 2+ uniporter channel (mtCU) and tunes mitochondrial metabolism to meet acute changes in cellular ATP demand. However, the role of mtCU-dependent mitochondrial Ca 2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce5baa627628cb5e92ee464c4e1d3fdb
https://doi.org/10.1161/circ.142.suppl_3.16592
https://doi.org/10.1161/circ.142.suppl_3.16592