Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Jonathan P Davis"'
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Myofilament calcium sensitivity is an often-used indicator of cardiac muscle function, often assessed in disease states such as hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). While calcium sensitivity measurement provides importa
Externí odkaz:
https://doaj.org/article/48a90610c5db44fc86a7d0474b0d504a
Autor:
Hussam E Salhi, Nathan C Hassel, Jalal K Siddiqui, Elizabeth A Brundage, Mark T Ziolo, Paul M L Janssen, Jonathan P Davis, Brandon J Biesiadecki
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Troponin I (TnI) is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially phosphorylated at multiple residues through different signaling pathways to match cardiac function
Externí odkaz:
https://doaj.org/article/b6d0a55bae744dad8330ce68ff05c383
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86279 (2014)
Adrenergic stimulation modulates cardiac function by altering the phosphorylation status of several cardiac proteins. The Troponin complex, which is the Ca(2+) sensor for cardiac contraction, is a hot spot for adrenergic phosphorylation. While the ef
Externí odkaz:
https://doaj.org/article/c87b17154ef54680ab41daa955aad980
Autor:
Shahla M. Jilani, Jonathan M. Davis, David Goldstein, Matthew Grossman, Lauren M. Jansson, Mishka Terplan, Hendrée E. Jones
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionAn increased incidence of maternal opioid use disorder (OUD) and neonatal abstinence syndrome (NAS) has prompted recommendations supporting a dyadic approach to care for birthing persons and their infants. However, there are no consensus
Externí odkaz:
https://doaj.org/article/82321dfdda1f493bbe88dbe7cb072848
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63608 (2013)
Pyruvate is a metabolic fuel that is a potent inotropic agent. Despite its unique inotropic and antioxidant properties, the molecular mechanism of its inotropic mechanism is still largely unknown. To examine the inotropic effect of pyruvate in parall
Externí odkaz:
https://doaj.org/article/ec20097183f64ceaafb149f568075bf1
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38259 (2012)
The contractile response of the heart can be altered by disease-related protein modifications to numerous contractile proteins. By utilizing an IAANS labeled fluorescent troponin C, [Formula: see text], we examined the effects of ten disease-related
Externí odkaz:
https://doaj.org/article/c19173a15b1447f9847988ad4ceaadbd
Autor:
Jianchao eZhang, Vikram eShettigar, George C. Zhang, Daniel G. Kindell, Xiaotong eLiu, Joseph J. Lopez, Vinatham eYerrimuni, Grace A. Davis, Jonathan P Davis
Publikováno v:
Frontiers in Physiology, Vol 2 (2011)
Parvalbumin (PV), an EF-hand protein family member, is a delayed calcium buffer that exchanges magnesium for calcium to facilitate fast skeletal muscle relaxation. Genetic approaches that express parvalbumin in the heart also enhance relaxation and s
Externí odkaz:
https://doaj.org/article/99d969e550a94b1a9a61773fe6c5ff29
Publikováno v:
Frontiers in Physiology, Vol 2 (2011)
Ca2+ dissociation from the regulatory domain of troponin C may influence the rate of striated muscle relaxation. However, Ca2+ dissociation from troponin C has not been measured within the geometric and stoichiometric constraints of the muscle fiber.
Externí odkaz:
https://doaj.org/article/c36953595eab4cb8bb3fa8854cd8d5c5
Autor:
Karel Allegaert, Thomas Salaets, Kelly Wade, Mary A. Short, Robert Ward, Kanwaljit Singh, Mark A. Turner, Jonathan M. Davis, Tamorah Lewis
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2024)
To support informed decisions on drug registration and prescription, clinical trials need tools to assess the efficacy and safety signals related to a given therapeutic intervention. Standardized assessment facilitates reproducibility of results. Fur
Externí odkaz:
https://doaj.org/article/223c7894f22a4f7792e0f5482c7aa5ee
Autor:
Alexandra B. Steverson, MD, MPH, Paul J. Marano, MD, Caren Chen, MPH, Yifei Ma, MS, Rachel J. Stern, MD, Jean Feng, MS, PhD, Efstathios D. Gennatas, MBBS, PhD, James D. Marks, MD, PhD, Matthew S. Durstenfeld, MD, MAS, Jonathan D. Davis, MD, MPHS, Priscilla Y. Hsue, MD, Lucas S. Zier, MD, MS
Publikováno v:
American Journal of Medicine Open, Vol 10, Iss , Pp 100060- (2023)
Introduction: Heart failure (HF) is a frequent cause of readmissions. Despite caring for underresourced patients and dependence on government funding, safety net hospitals frequently incur penalties for failing to meet pay-for-performance readmission
Externí odkaz:
https://doaj.org/article/8412fd4464a642a7b3a37c3dc292fd91