Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Jonathan P Butchar"'
Autor:
Kavin Fatehchand, Ramasamy Santhanam, Brenda Shen, Ericka L Erickson, Shalini Gautam, Saranya Elavazhagan, Xiaokui Mo, Tesfaye Belay, Susheela Tridandapani, Jonathan P Butchar
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181729 (2017)
Active Hexose Correlated Compound (AHCC) has been shown to have many immunostimulatory and anti-cancer activities in mice and in humans. As a natural product, AHCC has potential to create safer adjuvant therapies in cancer patients. Acute Myeloid Leu
Externí odkaz:
https://doaj.org/article/6f940099867e4baa8929e7abfbcec91d
Autor:
Devyn D Gilette, Heather M Curry, Thomas eCremer, David eRavneberg, Kavin eFatehchad, Prexy eShah, Mark D Wewers, Larry S Schlesinger, Jonathan P Butchar, Susheela eTridandapani, Mikhail A Gavrilin
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 4 (2014)
Francisella tularensis is a Gram-negative facultative bacterium that can cause the disease tularemia, even upon exposure to low numbers of bacteria. One critical characteristic of Francisella is its ability to dampen or subvert the host immune respon
Externí odkaz:
https://doaj.org/article/133474663892466ba14265149ed9a3a8
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 4 (2014)
Francisella tularensis can bypass and suppress host immune responses, even to the point of manipulating immune cell phenotypes and intercellular inflammatory networks. Strengthening these responses such that immune cells more readily identify and des
Externí odkaz:
https://doaj.org/article/95bd7475a5744a7eac66f0a0ac673718
Autor:
Giovanna Merchand-Reyes, Mikayla F. Bull, Ramasamy Santhanam, Maria L. Valencia-Pena, Rakesh A. Murugesan, Aadesh Chordia, Xiaokui-Molly Mo, Frank H. Robledo-Avila, Juan De Dios Ruiz-Rosado, William Edgar Carson, John C. Byrd, Jennifer A. Woyach, Susheela Tridandapani, Jonathan P. Butchar
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionTherapeutic antibodies have become a major strategy to treat oncologic diseases. For chronic lymphocytic leukemia, antibodies against CD20 are used to target and elicit cytotoxic responses against malignant B cells. However, efficacy is o
Externí odkaz:
https://doaj.org/article/2840c3664e3b44e69f5cbcfe156bc02d
Autor:
Susheela eTridandapani, Thomas John Cremer, Kavin eFatehchand, Prexy eShah, Devyn eGillette, Hemal ePatel, Rachel L Marsh, Beth Y Besecker, Murugesan VS Rajaram, Thirumala-Devi eKanneganti, Larry eSchlesinger, Jonathan P Butchar
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
MiR-155 regulates numerous aspects of innate and adaptive immune function. This miR is induced in response to toll-like receptor ligands, cytokines, and microbial infection. We have previously shown that miR-155 is induced in monocytes/macrophages in
Externí odkaz:
https://doaj.org/article/ebf8ba7451174c8783165c41d47ecd57
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2011)
Intracellular bacterial pathogens exploit host cells as a part of their lifecycle, and they do so by manipulating host cell signaling events. Many such bacteria are known to produce effector proteins that promote cell invasion, alter membrane traffic
Externí odkaz:
https://doaj.org/article/006c1e28e2a24c158191079205166a97
Autor:
Payal Mehta, Anne-Sophie Wavreille, Steven E Justiniano, Rachel L Marsh, Jianhua Yu, Richard W Burry, David Jarjoura, Timothy Eubank, Michael A Caligiuri, Jonathan P Butchar, Susheela Tridandapani
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21175 (2011)
SHIP and SHIP-2 are inositol phosphatases that regulate FcγR-mediated phagocytosis through catalytic as well as non-catalytic mechanisms. In this study we have used two-dimensional fluorescence difference gel electrophoresis (DIGE) analysis to ident
Externí odkaz:
https://doaj.org/article/1e33ad6609ce49a89f10bbe28f7e7648
Autor:
Thomas J Cremer, David H Ravneberg, Corey D Clay, Melissa G Piper-Hunter, Clay B Marsh, Terry S Elton, John S Gunn, Amal Amer, Thirumala-Devi Kanneganti, Larry S Schlesinger, Jonathan P Butchar, Susheela Tridandapani
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8508 (2009)
The intracellular gram-negative bacterium Francisella tularensis causes the disease tularemia and is known for its ability to subvert host immune responses. Previous work from our laboratory identified the PI3K/Akt pathway and SHIP as critical modula
Externí odkaz:
https://doaj.org/article/906f115ebd9345cebacd7a39e827e03c
Autor:
Murugesan V S Rajaram, Jonathan P Butchar, Kishore V L Parsa, Thomas J Cremer, Amal Amer, Larry S Schlesinger, Susheela Tridandapani
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7919 (2009)
Francisella tularensis infects macrophages and escapes phago-lysosomal fusion to replicate within the host cytosol, resulting in host cell apoptosis. Here we show that the Fas-mediated death pathway is activated in infected cells and correlates with
Externí odkaz:
https://doaj.org/article/d7968bac684a46f1b4e8c28013c8d14f
Autor:
Jonathan P Butchar, Thomas J Cremer, Corey D Clay, Mikhail A Gavrilin, Mark D Wewers, Clay B Marsh, Larry S Schlesinger, Susheela Tridandapani
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2924 (2008)
Francisella tularensis is a gram-negative facultative bacterium that causes the disease tularemia, even upon exposure to low numbers of bacteria. One critical characteristic of Francisella is its ability to dampen or subvert the host immune response.
Externí odkaz:
https://doaj.org/article/bd1bb32a8ade4262a7688f8bbfa56bf4