Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jonathan P, Hatcher"'
Autor:
Caroline B. A. Grahames, Julie Egerton, Paula J. Green, Jill C. Richardson, Anton D. Michel, Jonathan P. Hatcher, C. Bountra, Wendy L. Peck, Maria A Casula, Praveen Anand, Jane P. Hughes, Gary N. Buell, Yiangos Yiangou, Iain P. Chessell, Rolfe Birch, Melanie Murfin
Publikováno v:
Pain. 114:386-396
The P2X(7) purinoceptor is a ligand-gated cation channel, expressed predominantly by cells of immune origin, with a unique phenotype which includes release of biologically active inflammatory cytokine, interleukin (IL)-1beta following activation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23be61be9d8d85bd298687f8cda84e00
https://doi.org/10.1016/j.pain.2005.01.002
https://doi.org/10.1016/j.pain.2005.01.002
Autor:
Alejandro Abuin, David G. Reid, Sabrina A. Carter, Julie A. Buckingham, John C. Clapham, Lee James Beeley, Ines Lehner, Valerie Piercy, Alexander J. Harper, Nicole Herrity, Martin D. Brand, Stephen A. Smith, Brenda K. Trail, Sohaila Rastan, Robert James Godden, Andrea C. Haynes, Paul D. Hockings, Kumar Changani, Sarah M. Squires, Jonathan P. Hatcher, Helen Chapman, Mark Skehel, Judy Latcham, Gary B.T. Moore, Jonathan R.S. Arch, Susana Cadenas, Carolyn A. Lister
Publikováno v:
Nature. 406:415-418
Uncoupling protein-3 (UCP-3) is a recently identified member of the mitochondrial transporter superfamily that is expressed predominantly in skeletal muscle. However, its close relative UCP-1 is expressed exclusively in brown adipose tissue, a tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54580512c6113ca43c9a781435672afb
https://doi.org/10.1038/35019082
https://doi.org/10.1038/35019082
Autor:
Paula D. Slade, Derek N. Middlemiss, Jim J. Hagan, Laramie Mary Gaster, Jonathan P. Hatcher, Phillip Jeffrey
Publikováno v:
European Journal of Pharmacology. 331:169-174
The selective, brain penetrant, 5-HT(1B/D) (formerly 5-HT(1D beta/alpha)) receptor agonist SKF-99101H (3-(2-dimethylaminoethyl)-4-chloro-5-propoxyindole hemifumarate) (30 mg/kg i.p.) causes a dose related fall in rectal temperature in guinea pigs whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbebb3db0aebb53956631e0557929ca
https://doi.org/10.1016/s0014-2999(97)01055-8
https://doi.org/10.1016/s0014-2999(97)01055-8
Publikováno v:
Current pharmaceutical biotechnology. 12(10)
Chronic pain conditions present a huge burden on modern society. Both inflammatory and neuropathic pain are poorly treated in man; the majority of patients do not benefit from adequate pain relief, and side effects of currently used treatments are co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751a5c0caec67fb349f961aaa6dd9b9a
https://pubmed.ncbi.nlm.nih.gov/21466448
https://pubmed.ncbi.nlm.nih.gov/21466448
Autor:
Jonathan P, Hatcher, Iain P, Chessell
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 7(7)
Early validation of novel targets for the treatment of pain remains a key challenge, despite the recent technological advances which aid more rapid generation of pharmacological tools and molecular techniques that allow in vivo manipulation of gene t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89ace3dbc6dc599c0513e073621cc50a
https://pubmed.ncbi.nlm.nih.gov/16869119
https://pubmed.ncbi.nlm.nih.gov/16869119
Publikováno v:
Purinergic Signalling
The P2X ₇purinoceptor is unique amongst the P2X receptor family in that its activation is able to stimulate the release of mature, biologically active interleukin-1beta (IL-1β), as well as a variety of other proinflammatory cytokines. Coupled with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66021f8e7aeca32dab689c0e60e5248b
https://pubmed.ncbi.nlm.nih.gov/18404430
https://pubmed.ncbi.nlm.nih.gov/18404430
Publikováno v:
European journal of pharmacology. 294(2-3)
Systemic administration of 5-hydroxytryptophan (5-HTP) to guinea pigs causes species-specific, rhythmic, whole body jerks (myoclonic jerks), the frequency and amplitude of which were measured in an automated apparatus. The brain penetrant 5-HT1D rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc74c04c789696a7d3536b698d7ade9
https://pubmed.ncbi.nlm.nih.gov/8750741
https://pubmed.ncbi.nlm.nih.gov/8750741