Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jonathan P, Hannan"'
Autor:
Sarah J. Kane, Eric Swanson, Elizabeth O. Gordon, Savannah Rocha, Heather R. Bender, Luke R. Donius, Adriano Aguzzi, Jonathan P. Hannan, Mark D. Zabel
Publikováno v:
mSphere, Vol 2, Iss 6 (2017)
ABSTRACT Complement receptors 1 and 2 (CR1/2 or CD35/CD21) recognize complement-opsonized antigens to initiate innate and adaptive immunity, respectively. CD35 stimulates phagocytosis on macrophages and antigen presentation on follicular dendritic ce
Externí odkaz:
https://doaj.org/article/6f2c9ec8c79d4d4f811b088391cc4531
Autor:
Brandon Renner, Jennifer Laskowski, Felix Poppelaars, Viviana P. Ferreira, Judith Blaine, Alexandra H. Antonioli, Jonathan P. Hannan, James M. Kovacs, Cees van Kooten, Zhiying You, Matthew C. Pickering, V. Michael Holers, Joshua M. Thurman
Publikováno v:
Kidney International, 102(6), 1331-1344. ELSEVIER SCIENCE INC
Complement activation at a particular location is determined by the balance of activating and inhibitory proteins. Factor H is a key regulator of the alternative pathway of complement, and genetic or acquired impairments in Factor H are associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b9c5a0e8962f4134f64c8a84744000
https://doi.org/10.1016/j.kint.2022.07.035
https://doi.org/10.1016/j.kint.2022.07.035
Autor:
Ian R, Fleming, Jonathan P, Hannan, George Hayden, Swisher, Corey D, Tesdahl, Justin G, Martyr, Nicholas J, Cordaro, Annette H, Erbse, Joseph J, Falke
Publikováno v:
Analytical biochemistry. 663
Ras family GTPases (H/K/N-Ras) modulate numerous effectors, including the lipid kinase PI3K (phosphatidylinositol-3-kinase) that generates growth signal lipid PIP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e00da35b47d856082057cc18cd4e3ac
https://pubmed.ncbi.nlm.nih.gov/36526022
https://pubmed.ncbi.nlm.nih.gov/36526022
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166200 (2016)
Complement factor H-related protein 1 (CFHR1) is a complement regulator which has been reported to regulate complement by blocking C5 convertase activity and interfering with C5b surface association. CFHR1 also competes with complement factor H (CFH)
Externí odkaz:
https://doaj.org/article/753922ae84d34be68e456b80539a7f99
Autor:
Ian R. Fleming, Jonathan P. Hannan, George Hayden Swisher, Corey D. Tesdahl, Justin G. Martyr, Nicholas J. Cordaro, Annette H. Erbse, Joseph J. Falke
Publikováno v:
Analytical Biochemistry. 663:115019
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84401f0ded761136f55b4eaa8ce250a3
https://doi.org/10.1016/j.ab.2022.115019
https://doi.org/10.1016/j.ab.2022.115019
Autor:
G. Hayden Swisher, Justin G. Martyr, Jonathan P. Hannan, Joseph J. Falke, Annette H. Erbse, Nicholas J. Cordaro
Publikováno v:
Anal Biochem
The Ras superfamily of small G proteins play central roles in diverse signaling pathways. Superfamily members act as molecular on-off switches defined by their occupancy with GTP or GDP, respectively. In vitro functional studies require loading with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e28a62c9ae70ec902995fbdfaf1e742
https://europepmc.org/articles/PMC8511091/
https://europepmc.org/articles/PMC8511091/
Autor:
Justin G. Martyr, Joseph J. Falke, G. H. Swisher, Annette H. Erbse, Jonathan P. Hannan, Nicholas J. Cordaro
The Ras superfamily of small G proteins play central roles in diverse signaling pathways. Superfamily members act as molecular on-off switches defined by their occupancy with GTP or GDP, respectively. In vitro functional studies require loading with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b09fa3d95b53ef88cad3f8e1b8d20342
https://doi.org/10.1101/2021.06.28.450218
https://doi.org/10.1101/2021.06.28.450218
Autor:
Hugh P Morgan, Haydyn D T Mertens, Mara Guariento, Christoph Q Schmidt, Dinesh C Soares, Dmitri I Svergun, Andrew P Herbert, Paul N Barlow, Jonathan P Hannan
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32187 (2012)
Factor H (FH) is a soluble regulator of the human complement system affording protection to host tissues. It selectively inhibits amplification of C3b, the activation-specific fragment of the abundant complement component C3, in fluid phase and on se
Externí odkaz:
https://doaj.org/article/867b87b33f8e47b6b339f77f3225b596
Autor:
Annette H. Erbse, Nicholas J. Cordaro, Jonathan P. Hannan, G. Hayden Swisher, Joseph J. Falke
Publikováno v:
Anal Biochem
The many members of the Ras superfamily are small GTPases that serve as molecular switches. These proteins bind the guanine nucleotides GTP and GDP with picomolar affinities, thereby stabilizing on- and off-signaling states, respectively. Quantitativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5dad985e5b6d0c95414dd319b811e11
https://doi.org/10.1016/j.ab.2020.114066
https://doi.org/10.1016/j.ab.2020.114066
Autor:
Jonathan P. Hannan, Joshua M. Thurman, Yong Xing Li, Matthew C. Pickering, Karen R. Jonscher, V. Michael Holers, Jennifer Laskowski, Rachel A. Woolaver, Lindsey Goetz, H. H. Tong, Dennis E. Hourcade, Brandon Renner
Publikováno v:
The Journal of Immunology. 196:1355-1365
Factor H is a circulating protein that regulates activation of the alternative pathway (AP) of complement. Mutations and genetic variations of factor H are associated with several AP-mediated diseases, highlighting the critical role of factor H in AP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377a9cacc366e932acde1e2b7d4cd02d
https://doi.org/10.4049/jimmunol.1500793
https://doi.org/10.4049/jimmunol.1500793