Výsledky vyhledávání - "Jonathan Orenstein"

Quantitative Trait Analysis Reveals Transforming Growth Factor-β2 as a Positive Regulator of Early Hematopoietic Progenitor and Stem Cell Function

Autor: Els Henckaerts, Jonathan Orenstein, Hans-Willem Snoeck, Jessica C. Langer

Publikováno v: The Journal of Experimental Medicine

Elucidation of pathways involved in mouse strain-dependent variation in the hematopoietic stem cell (HSC) compartment may reveal novel mechanisms relevant in vivo. Here, we demonstrate genetically determined variation in the proliferation of lin-Sca1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041b753c47507b87abebef965adda8e8
https://doi.org/10.1084/jem.20030980

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The positive regulatory effect of TGF-beta 2 on primitive murine hemopoietic stem and progenitor cells is dependent on age, genetic background, and serum factors

Autor: Els Henckaerts, Hans-Willem Snoeck, Jessica C. Langer, Jonathan Orenstein

TGF-beta is considered a negative regulator of hemopoietic stem and progenitor cells. We have previously shown that one TGF-beta isoform, TGF-beta2, is, in fact, a positive regulator of murine hemopoietic stem cell function in vivo. In vitro, TGF-bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa2a425ac014ebd08f0d50dc6e59b80
https://lirias.kuleuven.be/handle/123456789/677231

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