Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jonathan O, Nelson"'
Publikováno v:
eLife, Vol 7 (2018)
rDNA loci, composed of hundreds of tandemly duplicated arrays of rRNA genes, are known to be among the most unstable genetic elements due to their repetitive nature. rDNA instability underlies aging (replicative senescence) in yeast cells, however, i
Externí odkaz:
https://doaj.org/article/db0c7c713aa144559b0257da01a8f993
Publikováno v:
Science Advances. 8
Although considered to be exact copies of each other, sister chromatids can segregate nonrandomly in some cases. For example, sister chromatids of the X and Y chromosomes segregate nonrandomly during asymmetric division of male germline stem cells (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c53cef73a1871c01387346590cc7cdef
https://doi.org/10.1126/sciadv.abo4443
https://doi.org/10.1126/sciadv.abo4443
Publikováno v:
eLife, Vol 5 (2016)
The nonsense-mediated mRNA decay (NMD) pathway functions to degrade both abnormal and wild-type mRNAs. NMD is essential for viability in most organisms, but the molecular basis for this requirement is unknown. Here we show that a single, conserved NM
Externí odkaz:
https://doaj.org/article/de95513addb34961acdcb4af11e3f7f3
Ribosomal RNAs (rRNAs) account for 80-90% of all transcripts in eukaryotic cells1. To meet this demand, the ribosomal DNA (rDNA) gene that codes for rRNA is tandemly repeated hundreds of times, comprising rDNA loci on eukaryotic chromosomes2-6. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f90c7f7c68912fa30a2c54f7478bffca
https://doi.org/10.1101/2021.07.12.451825
https://doi.org/10.1101/2021.07.12.451825
Publikováno v:
Trends Genet
Ribosomal DNA (rDNA), the genes encoding the RNA components of ribosomes (rRNA), are highly repetitive in all eukaryotic genomes, containing 100s to 1000s of copies, to meet the demand for ribosome biogenesis. rDNA genes are arranged in large stretch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4be2e5ef99d70a50173fc5954c15db9
https://doi.org/10.1016/j.tig.2019.07.006
https://doi.org/10.1016/j.tig.2019.07.006
Autor:
Dominique Foerster, Kimberley A. Frizzell, Stefan Luschnig, Mark M. Metzstein, Jonathan O. Nelson
Publikováno v:
Genetics. 209:1073-1084
The nonsense-mediated messenger RNA (mRNA) decay (NMD) pathway is a cellular quality control and post-transcriptional gene regulatory mechanism and is essential for viability in most multicellular organisms . A complex of proteins has been identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::227bb7398a97378db91fdb69abcf89f1
https://doi.org/10.1534/genetics.118.301140
https://doi.org/10.1534/genetics.118.301140
In many species, germline stem cells (GSCs) function to sustain gametogenesis throughout the life of organismal life span. As the source of gametes, the only cell type that can pass the genetic information to the next generation, GSCs play a fundamen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::579e8927564a20409958653dd68aaf51
https://doi.org/10.1016/bs.ctdb.2019.04.006
https://doi.org/10.1016/bs.ctdb.2019.04.006
Autor:
Jonathan O, Nelson, Dominique, Förster, Kimberly A, Frizzell, Stefan, Luschnig, Mark M, Metzstein
Publikováno v:
Genetics. 209(4)
The nonsense-mediated messenger RNA (mRNA) decay (NMD) pathway is a cellular quality control and post-transcriptional gene regulatory mechanism and is essential for viability in most multicellular organisms . A complex of proteins has been identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e0194819dde36f2286abc038119cc4e
https://pubmed.ncbi.nlm.nih.gov/29903866
https://pubmed.ncbi.nlm.nih.gov/29903866
Autor:
Jonathan O, Nelson, Mark M, Metzstein
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1720
Transcriptome analysis provides a snapshot of cellular gene expression and is used to determine how cells and organisms respond to genetic or environmental changes. Identifying the transcripts whose expression levels are regulated directly by the man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1983430651094500194d51092107fcd
https://pubmed.ncbi.nlm.nih.gov/29236261
https://pubmed.ncbi.nlm.nih.gov/29236261