Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal Cancer

Autor: Pei Loo Ow, Angel Garcia, Lesley Samuel, Rajarshi Roy, Adam McGeoch, D. Fyfe, W Saku, Simon Aird Grumett, Jonathan Nicoll, Jo Dent, Tom Samuel Waddell, Jo Webster, Christine Allmark, Tania Tillett, Colin Askill, Justin S. Waters, C. Handforth, Erica Beaumont, Vallipuram Vigneswaran, Sharon Ruddock, Nick Wadd, Syed Zubair, Kinnari Patel, Vanessa Potter, Daniel Propper, Olwyn Williams, Marc Jones, Kamalnayan Guptal, Peter Hall, Gareth Griffiths, Joseph Mano, Juan W. Valle, Sheela Rao, David A Cairns, Go Trial Investigators, Eszter Katona, Nick Maisey, Chris Twelves, Daniel Swinson, Nicholas Reed, Heike I. Grabsch, Joanne Askey, Jonathan Wadsley, Tom Roques, Sue Cheeseman, Stephen Falk, Louise Medley, Arshad Jamil, Emma Cattell, Victori Kunene, Matthew R. Sydes, Charles Candish, Claire Hobbs, Rebecca Herbertson, Jo Parkinson, Nicholas S. Reed, Louise Brook, Zuzana Stokes, Mohammed Khan, Ann Crossley, Elin Jones, George Bozas, Sebastian Cummins, Anirban Chatterjee, Michael Bennet, Helen Marshall, Pavel Bezecny, David Sherriff, Matthew T. Seymour, Lauren Gorf, Galina Velikova, Jean Gall, Kamposioras Konstantinos-Velios, Sally Clive, Eleanor James, Fiona Collinson, Dunca Wilkins, Simon Lord, Julia Brown, Serena Hilman, A. Robinson, Richard Ellis, Alaaeldin Shablak, Russell D Petty, Sherif Raouf, Helen Howard

Publikováno v: Hall, P S, Swinson, D, A. Cairns, D, S. Waters, J, Petty, R, Allmark, C, Ruddock, S, Falk, S, Wadsley, J, Roy, R, Tillett, T, Nicoll, J, Cummins, S, Mano, J, Grumett, S, Stokes, Z, Konstantinos-Velios, K, Chatterjee, A, Garcia, A, Waddell, T, Guptal, K, Maisey, N, Khan, M, Dent, J, Lord, S, Crossley, A, Katona, E, Marshall, H, I. Grabsch, H, Velikova, G, Loo Ow, P, Handforth, C, Howard, H & T. Seymour, M 2021, ' Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal CancerThe GO2 Phase 3 Randomized Clinical Trial ', JAMA Oncology . https://doi.org/10.1001/jamaoncol.2021.0848
JAMA Oncology, 7(6), 869-877. American Medical Association

Importance: Older and/or frail patients are underrepresented in landmark cancer trials. Tailored research is needed to address this evidence gap. Objective: The GO2 randomized clinical trial sought to optimize chemotherapy dosing in older and/or frai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957a450457d575d4bca5b7ef992b410c
https://doi.org/10.1001/jamaoncol.2021.0848

GLOBAL BALLAD: An International Rare Cancers Initiative trial to evaluate the potential benefit of adjuvant chemotherapy for small bowel adenocarcinoma (IRCI 002)

Autor: Manuel Salto-Tellez, Karine Le Malicot, Timothy Iveson, Albert J. ten Tije, Jonathan Nicoll, John Bridgewater, Kenichi Nakamura, Robert R. McWilliams, Richard H. Wilson, T.R. Jeffry Evans, Naureen Starling, Judith Dixon-Hughes, Ruth Boyd, James Paul, David Alan Anthoney, Kein Yim, Janet Graham, Yoshitaka Honma, Makoto Ueno, Thomas Aparicio

Publikováno v: Journal of Clinical Oncology. 34:TPS4154-TPS4154

TPS4154Background: Small bowel adenocarcinoma (SBA) is a rare cancer (< 5% of gastrointestinal tumours) with poor prognosis at all stages. There are no RCTs of adjuvant treatment following definiti...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78f8dfe8498187612c44e56c56c55e28
https://doi.org/10.1200/jco.2016.34.15_suppl.tps4154

Numerical Study of the Winter–Kennedy Flow Measurement Method in Transient Flows

Autor: Binaya Baidar, Jonathan Nicolle, Bhupendra K. Gandhi, Michel J. Cervantes

Publikováno v: Energies, Vol 13, Iss 6, p 1310 (2020)

This paper explores the possibility of using the Winter−Kennedy (WK) method for transient flow rate measurement in hydraulic turbines. Computational fluid dynamic (CFD) analysis of a numerical model of an axial turbine was carried out for accelerat

Externí odkaz: https://doaj.org/article/0238dd0396424d8eb840dd45a02e900a