Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jonathan Michael Blackburn"'
Autor:
Metoboroghene Oluwaseyi Mowoe, Shaun Garnett, Katherine Lennard, Jade Talbot, Paul Townsend, Eduard Jonas, Jonathan Michael Blackburn
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background The central role of proteins in diseases has made them increasingly attractive as therapeutic targets and indicators of cellular processes. Protein microarrays are emerging as an important means of characterising protein activity.
Externí odkaz:
https://doaj.org/article/1c93af11f4e8496aa3fa046cfefe2ea4
Autor:
April C. Pettit, Andrew J.M. Nel, David W. Wright, Carlos Zamudio, Frederick R. Haselton, Mark L. Baglia, Megan E. Pask, Keersten M. Ricks, Keertan Dheda, Hali Bordelon, Francesca Solinas, Patricia K. Russ, Tatiana Cáceres, Philip A. Short, Jonathan Michael Blackburn
Urine samples are increasingly used for diagnosing infections including Escherichia coli, Ebola virus, and Zika virus. However, extraction and concentration of nucleic acid biomarkers from urine is necessary for many molecular detection strategies su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7c930098e0834861b260dcd4529acd
https://hdl.handle.net/20.500.12866/4631
https://hdl.handle.net/20.500.12866/4631
Publikováno v:
Biochemistry. 34:7548-7562
Isopenicillin N synthase (IPNS) catalyzes the oxidative cyclization of delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine to isopenicillin N. It is proposed that the multiple products produced from certain substrate analogues result from pathway branc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a0c7c9b35ad8a832385710466b76f1
https://doi.org/10.1021/bi00022a031
https://doi.org/10.1021/bi00022a031
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:663-668
The deacetoxycephalosporin C/deacetylcephalosporin C synthase gene from Cephalosporium acremonium has been expressed at high levels in E. coli under control of the trc promoter in a vector modified by PCR. The enzyme is produced in soluble, highly ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b93d553ce57418835f275b4ed6529679
https://doi.org/10.1016/s0960-894x(00)80386-8
https://doi.org/10.1016/s0960-894x(00)80386-8
Publikováno v:
Tetrahedron. 47:5991-6002
The Isopenicillin N Synthase genes from Cephalosporium acremonium, Penicillium chrysogenum and Aspergillus nidulans have been expressed at high levels in Escherichia coli under control of the trc or lac promoters. The enzymes are produced in soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7959ad9a16addff18c78055fecb8193f
https://doi.org/10.1016/s0040-4020(01)86491-7
https://doi.org/10.1016/s0040-4020(01)86491-7
Publikováno v:
Biocatalysis. 3:129-136
The synthesis of L-α-aminoadipoyl-L-cysteinyl-D-(2-amino-3-methylpropa-3,4-dienoic acid) and its subsequent incubation with isopenicillin N synthase (IPNS) was carried out. A single bicyclic product was detected by 'Hn.m.r. of the crude incubation m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa2e8a74ae377dac783e618a1376821d
https://doi.org/10.3109/10242429008992055
https://doi.org/10.3109/10242429008992055
Publikováno v:
J. Chem. Soc., Chem. Commun.. :970-972
Incubation of isopenicillin N synthase (IPNS) with [(5S)-5-amino-5- carboxypentanoyl]-L- homocysteinyl-L-cysteine (14) resulted in the formation of a novel bicyclic γ-lactam (17) containing an intramolecular disulphide linkage.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c5b8a895d2ac76abee86deb1b201c4
https://doi.org/10.1039/c39890000970
https://doi.org/10.1039/c39890000970